Gene description for TNFAIP3
Gene name	tumor necrosis factor, alpha-induced protein 3
Gene symbol	TNFAIP3
Other names/aliases	A20 OTUD7C TNFA1P2
Species	Homo sapiens
Database cross references - TNFAIP3
ExoCarta	ExoCarta_7128
Entrez Gene	7128
HGNC	11896
MIM	191163
UniProt	P21580
TNFAIP3 identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337

Gene ontology annotations for TNFAIP3

Molecular Function     DNA binding GO:0003677 IEA     ligase activity GO:0016874 IEA     zinc ion binding GO:0008270 IEA     protein self-association GO:0043621 IDA     ubiquitin-specific protease activity GO:0004843 TAS     protein binding GO:0005515 IPI     kinase binding GO:0019900 IEA     ubiquitin binding GO:0043130 IPI     ubiquitin-protein transferase activity GO:0004842 IDA     protease binding GO:0002020 IPI Biological Process     inflammatory response GO:0006954 IEA     negative regulation of chronic inflammatory response GO:0002677 IEA     tolerance induction to lipopolysaccharide GO:0072573 IMP     positive regulation of protein catabolic process GO:0045732 IDA     negative regulation of interleukin-1 beta production GO:0032691 IEA     cellular response to lipopolysaccharide GO:0071222 IDA     B-1 B cell homeostasis GO:0001922 ISS     negative regulation of inflammatory response GO:0050728 ISS     regulation of defense response to virus by host GO:0050691 NAS     negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IEA     positive regulation of hepatocyte proliferation GO:2000347 IEA     negative regulation of bone resorption GO:0045779 NAS     innate immune response GO:0045087 TAS     negative regulation of toll-like receptor 5 signaling pathway GO:0034148 IEA     response to molecule of bacterial origin GO:0002237 IDA     negative regulation of toll-like receptor 4 signaling pathway GO:0034144 NAS     negative regulation of type I interferon production GO:0032480 TAS     negative regulation of interleukin-6 production GO:0032715 ISS     protein oligomerization GO:0051259 NAS     apoptotic process GO:0006915 IEA     protein K63-linked deubiquitination GO:0070536 IDA     negative regulation of osteoclast proliferation GO:0090291 NAS     protein K11-linked deubiquitination GO:0035871 IDA     negative regulation of smooth muscle cell proliferation GO:0048662 IDA     negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 IEA     negative regulation of innate immune response GO:0045824 ISS     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 NAS     negative regulation of B cell activation GO:0050869 ISS     cellular response to hydrogen peroxide GO:0070301 ISS     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IDA     protein K48-linked deubiquitination GO:0071108 IDA     negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070429 IEA     negative regulation of CD40 signaling pathway GO:2000349 IMP     negative regulation of interleukin-2 production GO:0032703 IMP     regulation of germinal center formation GO:0002634 ISS     negative regulation of endothelial cell apoptotic process GO:2000352 IDA     negative regulation of protein ubiquitination GO:0031397 IDA     nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     establishment of protein localization to vacuole GO:0072666 IEA     protein K48-linked ubiquitination GO:0070936 IDA     regulation of vascular wound healing GO:0061043 NAS     protein deubiquitination GO:0016579 TAS     negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA     response to muramyl dipeptide GO:0032495 IEA     negative regulation of toll-like receptor 3 signaling pathway GO:0034140 IDA     negative regulation of tumor necrosis factor production GO:0032720 ISS     negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IDA     positive regulation of cellular protein catabolic process GO:1903364 IEA Subcellular Localization     lysosome GO:0005764 IEA     extracellular exosome GO:0070062 IDA     cytosol GO:0005829 TAS     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA     centrosome GO:0005813 IDA