Gene description for Il17ra
Gene name interleukin 17 receptor A
Gene symbol Il17ra
Other names/aliases AW538159
Cdw217
Il17r
VDw217
Species Mus musculus
 Database cross references - Il17ra
ExoCarta ExoCarta_16172
Vesiclepedia VP_16172
Entrez Gene 16172
UniProt Q60943  
 Il17ra identified in exosomes derived from the following tissue/cell type
Breast cancer cells 34112803    
Breast cancer cells 34112803    
 Gene ontology annotations for Il17ra
Molecular Function
    interleukin-17 receptor activity GO:0030368 IBA
Biological Process
    positive regulation of interleukin-23 production GO:0032747 ISO
    fibroblast activation GO:0072537 ISO
    positive regulation of cytokine production involved in inflammatory response GO:1900017 IGI
    cytokine-mediated signaling pathway GO:0019221 IBA
    cellular response to cytokine stimulus GO:0071345 ISO
Subcellular Localization
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IEA
    integral component of plasma membrane GO:0005887 IBA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Il17ra in exosomes
1
Experiment ID 520
MISEV standards
EM
EV Biophysical techniques
Tsg101|Cd9
EV Enriched markers
Golga2
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34112803    
Organism Mus musculus
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A.
Journal name Nat Commun
Publication year 2021
Sample Breast cancer cells
Sample name EO771
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 521
MISEV standards
EM
EV Biophysical techniques
Tsg101|Cd9
EV Enriched markers
Golga2
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34112803    
Organism Mus musculus
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A.
Journal name Nat Commun
Publication year 2021
Sample Breast cancer cells
Sample name PyMT
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for Il17ra
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Il17ra is involved
No pathways found





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