Gene description for FABP4
Gene name fatty acid binding protein 4, adipocyte
Gene symbol FABP4
Other names/aliases A-FABP
AFABP
ALBP
HEL-S-104
aP2
Species Homo sapiens
 Database cross references - FABP4
ExoCarta ExoCarta_2167
Vesiclepedia VP_2167
Entrez Gene 2167
HGNC 3559
MIM 600434
UniProt P15090  
 FABP4 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FABP4
Molecular Function
    long-chain fatty acid transmembrane transporter activity GO:0005324 ISS
    fatty acid binding GO:0005504 IBA
    long-chain fatty acid binding GO:0036041 ISS
    hormone receptor binding GO:0051427 IEA
Biological Process
    response to bacterium GO:0009617 IEA
    fatty acid transport GO:0015908 IBA
    long-chain fatty acid transport GO:0015909 ISS
    cholesterol homeostasis GO:0042632 IEA
    negative regulation of DNA-templated transcription GO:0045892 IEA
    positive regulation of inflammatory response GO:0050729 IEA
    white fat cell differentiation GO:0050872 IEA
    brown fat cell differentiation GO:0050873 IEA
    cellular response to lithium ion GO:0071285 IEA
    cellular response to tumor necrosis factor GO:0071356 IEA
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
    cytoplasm GO:0005737 TAS
    lipid droplet GO:0005811 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FABP4 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FABP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SCG5  
Affinity Capture-MS Homo sapiens
2 PRKCI 5584
Two-hybrid Homo sapiens
3 ACTB 60
Two-hybrid Homo sapiens
4 EXT2 2132
Affinity Capture-MS Homo sapiens
5 TNK2 10188
Affinity Capture-Western Homo sapiens
6 LIPE  
FRET Homo sapiens
FRET Homo sapiens
7 OAZ3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 VIPR2  
Affinity Capture-MS Homo sapiens
9 CHD3 1107
Two-hybrid Homo sapiens
10 VIM 7431
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 SNCG 6623
Affinity Capture-MS Homo sapiens
12 GDF5 8200
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TNFAIP3 7128
Two-hybrid Homo sapiens
14 USP15 9958
Affinity Capture-MS Homo sapiens
15 ZBED1  
Two-hybrid Homo sapiens
16 FOXN3 1112
Affinity Capture-MS Homo sapiens
17 OSTF1 26578
Affinity Capture-MS Homo sapiens
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