Gene description for USP15
Gene name ubiquitin specific peptidase 15
Gene symbol USP15
Other names/aliases UNPH-2
Species Homo sapiens
 Database cross references - USP15
ExoCarta ExoCarta_9958
Entrez Gene 9958
HGNC 12613
MIM 604731
UniProt Q9Y4E8  
 USP15 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for USP15
Molecular Function
    cysteine-type endopeptidase activity GO:0004197 IMP
    protein binding GO:0005515 IPI
    transforming growth factor beta receptor binding GO:0005160 IPI
    ubiquitin-specific protease activity GO:0004843 IDA
    SMAD binding GO:0046332 IPI
    identical protein binding GO:0042802 IPI
    ubiquitinated histone binding GO:0061649 IDA
Biological Process
    monoubiquitinated protein deubiquitination GO:0035520 IDA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 TAS
    BMP signaling pathway GO:0030509 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    regulation of proteasomal protein catabolic process GO:0061136 IBA
    histone H2B conserved C-terminal lysine deubiquitination GO:0035616 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    protein deubiquitination GO:0016579 IDA
    pathway-restricted SMAD protein phosphorylation GO:0060389 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified USP15 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for USP15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD40 958
Affinity Capture-MS Homo sapiens
2 DFFA  
Affinity Capture-MS Homo sapiens
3 PHB2 11331
Affinity Capture-MS Homo sapiens
4 UBE2G2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which USP15 is involved
Downregulation of TGF-beta receptor signaling TAS Reactome

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