Gene description for RORC
Gene name RAR-related orphan receptor C
Gene symbol RORC
Other names/aliases NR1F3
RORG
RZR-GAMMA
RZRG
TOR
Species Homo sapiens
 Database cross references - RORC
ExoCarta ExoCarta_6097
Vesiclepedia VP_6097
Entrez Gene 6097
HGNC 10260
MIM 602943
UniProt P51449  
 RORC identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for RORC
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISS
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription factor activity GO:0003700 ISS
    nuclear receptor activity GO:0004879 IBA
    protein binding GO:0005515 IPI
    oxysterol binding GO:0008142 IBA
    oxysterol binding GO:0008142 IDA
    zinc ion binding GO:0008270 IEA
    ligand-activated transcription factor activity GO:0098531 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    xenobiotic metabolic process GO:0006805 ISS
    regulation of glucose metabolic process GO:0010906 ISS
    regulation of steroid metabolic process GO:0019218 ISS
    intracellular receptor signaling pathway GO:0030522 IEA
    circadian regulation of gene expression GO:0032922 ISS
    cellular response to sterol GO:0036315 IDA
    T-helper cell differentiation GO:0042093 ISS
    positive regulation of circadian rhythm GO:0042753 ISS
    regulation of fat cell differentiation GO:0045598 ISS
    positive regulation of DNA-templated transcription GO:0045893 ISS
    lymph node development GO:0048535 ISS
    Peyer's patch development GO:0048541 ISS
    adipose tissue development GO:0060612 ISS
    negative regulation of thymocyte apoptotic process GO:0070244 ISS
    T-helper 17 cell differentiation GO:0072539 ISS
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 TAS
    nuclear body GO:0016604 IDA
 Experiment description of studies that identified RORC in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
3
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
4
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
5
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for RORC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARNTL  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
2 FBXL15  
Two-hybrid Homo sapiens
3 NCOA6  
Two-hybrid Homo sapiens
4 SCGB1D2  
Affinity Capture-MS Homo sapiens
5 PER2  
Two-hybrid Homo sapiens
6 PPP1CB 5500
Two-hybrid Homo sapiens
7 TP53 7157
Affinity Capture-MS Homo sapiens
8 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KIF14 9928
Affinity Capture-MS Homo sapiens
10 SRC 6714
Affinity Capture-Western Homo sapiens
11 USP15 9958
Affinity Capture-Western Homo sapiens
12 CLOCK  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
13 GLB1 2720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PPP1CA 5499
Two-hybrid Homo sapiens
15 DEC1  
Two-hybrid Homo sapiens
16 BHLHE41  
Two-hybrid Homo sapiens
17 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 RORB  
Two-hybrid Homo sapiens
19 NPAS2  
Two-hybrid Homo sapiens
20 CUL4B 8450
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
21 PPP1CC 5501
Two-hybrid Homo sapiens
22 CTSA 5476
Affinity Capture-MS Homo sapiens
23 PPP2R1B 5519
Two-hybrid Homo sapiens
24 PPP2R1A 5518
Two-hybrid Homo sapiens
25 PPP2R5E 5529
Two-hybrid Homo sapiens
26 PPP2R5D 5528
Two-hybrid Homo sapiens
27 TRAF5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 USP19 10869
Affinity Capture-Western Homo sapiens
29 PPP2CA 5515
Two-hybrid Homo sapiens
30 PSMC5 5705
Two-hybrid Homo sapiens
31 CSNK1E 1454
Two-hybrid Homo sapiens
32 EVI2A  
Two-hybrid Homo sapiens
33 ARNTL2  
Two-hybrid Homo sapiens
34 NCOA3  
Affinity Capture-Western Homo sapiens
35 CIPC  
Two-hybrid Homo sapiens
36 NR1D2  
Two-hybrid Homo sapiens
37 EP300 2033
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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