Gene description for RORC
Gene name RAR-related orphan receptor C
Gene symbol RORC
Other names/aliases NR1F3
RORG
RZR-GAMMA
RZRG
TOR
Species Homo sapiens
 Database cross references - RORC
ExoCarta ExoCarta_6097
Entrez Gene 6097
HGNC 10260
MIM 602943
UniProt P51449  
 RORC identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for RORC
Molecular Function
    sequence-specific DNA binding GO:0043565 ISS
    oxysterol binding GO:0008142 IDA
    steroid hormone receptor activity GO:0003707 IEA
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 IEA
    direct ligand regulated sequence-specific DNA binding transcription factor activity GO:0098531 IDA
    DNA binding GO:0003677 ISS
    zinc ion binding GO:0008270 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 ISS
    transcription coactivator binding GO:0001223 IEA
    protein binding GO:0005515 IPI
Biological Process
    T-helper cell differentiation GO:0042093 ISS
    Peyer's patch development GO:0048541 ISS
    regulation of gamma-delta T cell differentiation GO:0045586 IEA
    circadian regulation of gene expression GO:0032922 ISS
    intracellular receptor signaling pathway GO:0030522 TAS
    gene expression GO:0010467 TAS
    cellular response to sterol GO:0036315 IDA
    xenobiotic metabolic process GO:0006805 ISS
    regulation of transcription involved in cell fate commitment GO:0060850 ISS
    negative regulation of thymocyte apoptotic process GO:0070244 ISS
    regulation of steroid metabolic process GO:0019218 ISS
    protein phosphorylation GO:0006468 IEA
    regulation of fat cell differentiation GO:0045598 ISS
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    adipose tissue development GO:0060612 ISS
    regulation of glucose metabolic process GO:0010906 ISS
    T-helper 17 cell differentiation GO:0072539 ISS
    steroid hormone mediated signaling pathway GO:0043401 IEA
    lymph node development GO:0048535 ISS
    T cell differentiation in thymus GO:0033077 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    positive regulation of circadian rhythm GO:0042753 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified RORC in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
3
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
4
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
5
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for RORC
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RORC is involved
PathwayEvidenceSource
Nuclear Receptor transcription pathway TAS Reactome





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