Gene description for TP53
Gene name tumor protein p53
Gene symbol TP53
Other names/aliases BCC7
LFS1
P53
TRP53
Species Homo sapiens
 Database cross references - TP53
ExoCarta ExoCarta_7157
Vesiclepedia VP_7157
Entrez Gene 7157
HGNC 11998
MIM 191170
UniProt P04637  
 TP53 identified in exosomes derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for TP53
Molecular Function
    enzyme binding GO:0019899 IPI
    receptor tyrosine kinase binding GO:0030971 IPI
    double-stranded DNA binding GO:0003690 IBA
    protein heterodimerization activity GO:0046982 IPI
    core promoter sequence-specific DNA binding GO:0001046 ISS
    protease binding GO:0002020 IPI
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 IDA
    RNA polymerase II transcription factor binding GO:0001085 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    transcription regulatory region DNA binding GO:0044212 IDA
    protein phosphatase binding GO:0019903 IPI
    protein N-terminus binding GO:0047485 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    histone acetyltransferase binding GO:0035035 IPI
    MDM2/MDM4 family protein binding GO:0097371 IEA
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA
    histone deacetylase regulator activity GO:0035033 IEA
    protein self-association GO:0043621 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IEA
    DNA binding GO:0003677 IMP
    copper ion binding GO:0005507 IDA
    zinc ion binding GO:0008270 TAS
    ATP binding GO:0005524 IDA
    transcription factor binding GO:0008134 IPI
    identical protein binding GO:0042802 IPI
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IDA
    protein binding GO:0005515 IPI
    damaged DNA binding GO:0003684 IBA
    sequence-specific DNA binding GO:0043565 IBA
    p53 binding GO:0002039 IBA
    protein phosphatase 2A binding GO:0051721 IPI
    chromatin binding GO:0003682 IDA
    protein kinase binding GO:0019901 IPI
    chaperone binding GO:0051087 IPI
Biological Process
    T cell proliferation involved in immune response GO:0002309 IEA
    circadian behavior GO:0048512 ISS
    protein complex assembly GO:0006461 IDA
    negative regulation of helicase activity GO:0051097 TAS
    neuron apoptotic process GO:0051402 IEA
    regulation of apoptotic process GO:0042981 IDA
    multicellular organismal development GO:0007275 IMP
    cellular response to DNA damage stimulus GO:0006974 IDA
    regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902253 IEA
    mitotic cell cycle arrest GO:0071850 IEA
    Notch signaling pathway GO:0007219 TAS
    positive regulation of histone deacetylation GO:0031065 IBA
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    cell aging GO:0007569 IMP
    gene expression GO:0010467 TAS
    positive regulation of cardiac muscle cell apoptotic process GO:0010666 IEA
    oligodendrocyte apoptotic process GO:0097252 IDA
    determination of adult lifespan GO:0008340 ISS
    DNA strand renaturation GO:0000733 IDA
    positive regulation of release of cytochrome c from mitochondria GO:0090200 IDA
    cellular response to hypoxia GO:0071456 IEP
    regulation of tissue remodeling GO:0034103 IEA
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 IMP
    protein import into nucleus, translocation GO:0000060 IEA
    positive regulation of thymocyte apoptotic process GO:0070245 ISS
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    chromatin assembly GO:0031497 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    regulation of transcription, DNA-templated GO:0006355 IDA
    multicellular organism growth GO:0035264 IEA
    positive regulation of execution phase of apoptosis GO:1900119 IMP
    entrainment of circadian clock by photoperiod GO:0043153 ISS
    double-strand break repair GO:0006302 IEA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IMP
    negative regulation of neuroblast proliferation GO:0007406 IEA
    cell proliferation GO:0008283 TAS
    release of cytochrome c from mitochondria GO:0001836 IEA
    replicative senescence GO:0090399 IMP
    ER overload response GO:0006983 IDA
    cellular response to UV GO:0034644 IBA
    negative regulation of cell proliferation GO:0008285 ISS
    mitotic G1 DNA damage checkpoint GO:0031571 IMP
    B cell lineage commitment GO:0002326 IEA
    regulation of mitochondrial membrane permeability GO:0046902 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA
    regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 IEA
    rRNA transcription GO:0009303 IEA
    cellular response to ionizing radiation GO:0071479 IMP
    negative regulation of fibroblast proliferation GO:0048147 IMP
    negative regulation of reactive oxygen species metabolic process GO:2000378 IEA
    positive regulation of cell cycle arrest GO:0071158 IMP
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS
    positive regulation of apoptotic process GO:0043065 IDA
    somitogenesis GO:0001756 IEA
    regulation of fibroblast apoptotic process GO:2000269 IEA
    cell differentiation GO:0030154 TAS
    response to salt stress GO:0009651 IEA
    Ras protein signal transduction GO:0007265 IEP
    response to antibiotic GO:0046677 IEP
    cellular response to glucose starvation GO:0042149 IDA
    base-excision repair GO:0006284 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    blood coagulation GO:0007596 TAS
    DNA damage response, signal transduction by p53 class mediator GO:0030330 IMP
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 TAS
    cellular protein localization GO:0034613 IDA
    negative regulation of DNA replication GO:0008156 IEA
    cellular response to drug GO:0035690 IEP
    T cell lineage commitment GO:0002360 IEA
    positive regulation of neuron apoptotic process GO:0043525 IBA
    apoptotic process GO:0006915 TAS
    positive regulation of reactive oxygen species metabolic process GO:2000379 IMP
    necroptotic process GO:0070266 IEA
    viral process GO:0016032 IMP
    positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 ISS
    positive regulation of protein oligomerization GO:0032461 IDA
    intrinsic apoptotic signaling pathway GO:0097193 TAS
    protein localization GO:0008104 IDA
    response to X-ray GO:0010165 IBA
    response to gamma radiation GO:0010332 IMP
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IMP
    in utero embryonic development GO:0001701 IEA
    mitochondrial DNA repair GO:0043504 IEA
    embryonic organ development GO:0048568 IEA
    gastrulation GO:0007369 IEA
    response to ischemia GO:0002931 IEA
    T cell differentiation in thymus GO:0033077 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    cerebellum development GO:0021549 IEA
    positive regulation of cell aging GO:0090343 IEA
    programmed cell death GO:0012501 TAS
    negative regulation of cell growth GO:0030308 IMP
    oxidative stress-induced premature senescence GO:0090403 IMP
    positive regulation of mitochondrial membrane permeability GO:0035794 IEA
    protein tetramerization GO:0051262 TAS
    nucleotide-excision repair GO:0006289 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of macromitophagy GO:1901525 IEA
    cell cycle arrest GO:0007050 IMP
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    protein complex GO:0043234 IDA
    transcription factor TFIID complex GO:0005669 IDA
    nucleolus GO:0005730 IDA
    nuclear body GO:0016604 IDA
    PML body GO:0016605 IDA
    nuclear matrix GO:0016363 IDA
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 IDA
    nuclear chromatin GO:0000790 IDA
    mitochondrial matrix GO:0005759 IEA
    replication fork GO:0005657 IBA
    nucleoplasm GO:0005654 TAS
    mitochondrion GO:0005739 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified TP53 in exosomes
1
Experiment ID 426
MISEV standards
✘ EV Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
EV Enriched markers
✔
CANX
EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R.
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 427
MISEV standards
✘ EV Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
EV Enriched markers
✔
CANX
EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R.
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 497
MISEV standards
✘ EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 419
MISEV standards
✘ EV Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
EV Enriched markers
✔
CANX
EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R.
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 419
MISEV standards
✘ EV Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
EV Enriched markers
✔
CANX
EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R.
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 420
MISEV standards
✘ EV Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
EV Enriched markers
✔
CANX
EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R.
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 420
MISEV standards
✘ EV Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
EV Enriched markers
✔
CANX
EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R.
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 434
MISEV standards
✘ EV Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
EV Enriched markers
✔
CANX
EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R.
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 435
MISEV standards
✘ EV Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
EV Enriched markers
✔
CANX
EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R.
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TP53
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
2 POLA  
Invivo Homo sapiens
3 ZNF24  
Two-hybrid Homo sapiens
4 UBE2A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
5 TK1 7083
Two-hybrid Homo sapiens
6 HDAC1 3065
Affinity Capture-Western Homo sapiens
7 THRB 7068
Affinity Capture-Western Homo sapiens
8 ERCC2 2068
Affinity Capture-MS Homo sapiens
9 ANXA3 306
Two-hybrid Homo sapiens
10 KPNB1 3837
Invivo Homo sapiens
11 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
12 HSU79303  
Two-hybrid Homo sapiens
13 TSG101 7251
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
14 UBE3A 7337
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
15 CABLES2  
Affinity Capture-Western Homo sapiens
16 MAD2L1BP  
Two-hybrid Homo sapiens
17 ATM 472
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Enhancement Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
18 KPNA2 3838
Affinity Capture-MS Homo sapiens
19 PSMD11 5717
Two-hybrid Homo sapiens
20 ANKRD2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
21 TAF1  
Invitro Homo sapiens
22 PRKDC 5591
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Invitro Homo sapiens
23 MAPK10 5602
Invivo Homo sapiens
24 CREBBP  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Suppression Homo sapiens
25 APEX1 328
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
26 ELL  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
27 XRCC1 7515
Affinity Capture-Western Homo sapiens
28 TOP2A 7153
Invivo Homo sapiens
Invitro Homo sapiens
29 S100A4 6275
Reconstituted Complex Homo sapiens
30 ARL3 403
Two-hybrid Homo sapiens
31 TAF9 6880
Invitro Homo sapiens
32 YWHAZ 7534
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
33 EGR1  
Invitro Homo sapiens
Invivo Homo sapiens
34 WT1  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
35 TFAP2C 7022
Reconstituted Complex Homo sapiens
36 RRM2B 50484
Affinity Capture-Western Homo sapiens
37 ZNF148  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
38 BRCC3 79184
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
39 CCNH  
Invivo Homo sapiens
40 Hipk1 predicted  
Two-hybrid Rattus norvegicus
41 TDG 6996
Two-hybrid Homo sapiens
42 RAD51  
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
43 LAMA4 3910
Two-hybrid Homo sapiens
44 PRKRA 8575
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
45 KLF4  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
46 PHB 5245
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
47 E4F1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
48 SFN 2810
Affinity Capture-Western Homo sapiens
49 THAP8  
Two-hybrid Homo sapiens
50 COX17  
Two-hybrid Homo sapiens
51 ARIH2 10425
Two-hybrid Homo sapiens
52 CSNK1D 1453
Affinity Capture-MS Homo sapiens
53 CHD3 1107
Two-hybrid Homo sapiens
54 SMARCB1 6598
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
55 CCT5 22948
Two-hybrid Homo sapiens
56 MTA2 9219
Reconstituted Complex Homo sapiens
57 DVL2 1856
Two-hybrid Homo sapiens
58 GSK3B 2932
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
59 HSPA1A  
Affinity Capture-MS Homo sapiens
60 WRN 7486
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
61 SERPINB9 5272
Two-hybrid Homo sapiens
62 RAB4A 5867
Two-hybrid Homo sapiens
63 TFAP2A  
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
64 TP53INP1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
65 AURKA 6790
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
66 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
67 PPP1CA 5499
Affinity Capture-MS Homo sapiens
68 ING4  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
69 MAPK3 5595
Invivo Homo sapiens
70 EPHA3 2042
Reconstituted Complex Homo sapiens
71 TOP2B 7155
Invivo Homo sapiens
Invitro Homo sapiens
72 CDKN1A  
Affinity Capture-Western Homo sapiens
73 PTGS2 5743
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
74 TP53BP2  
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
75 ERCC6  
Invivo Homo sapiens
Invitro Homo sapiens
76 BRE 9577
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
77 BLM 641
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
78 KIAA0087  
Two-hybrid Homo sapiens
79 UBE2I 7329
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
80 TAG  
Affinity Capture-Western Homo sapiens
81 HTT 3064
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
82 TFDP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
83 BRCA2 675
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
84 SMARCA4 6597
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
85 CARM1 10498
Reconstituted Complex Homo sapiens
86 CR2 1380
Invitro Homo sapiens
87 MNAT1  
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
88 BARD1 580
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
89 CDKN2C  
Two-hybrid Homo sapiens
90 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
91 S100A8 6279
Two-hybrid Homo sapiens
92 CHEK1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
93 MTA1 9112
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
94 PPP2CA 5515
Affinity Capture-MS Homo sapiens
95 PCDHA4 56144
Two-hybrid Homo sapiens
96 SNRPN 6638
Two-hybrid Homo sapiens
97 S100B 6285
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
98 CSNK1E 1454
Affinity Capture-MS Homo sapiens
99 PML 5371
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
100 STX5 6811
Two-hybrid Homo sapiens
101 GTF2H1 2965
Reconstituted Complex Homo sapiens
102 APTX  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
103 PARC  
Invitro Homo sapiens
Invivo Homo sapiens
104 ATF3  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
105 HMGB2 3148
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
106 GPS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
107 RPL11 6135
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
108 CDC14A  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
109 CABLES1  
Affinity Capture-Western Homo sapiens
110 DLEU1  
Two-hybrid Homo sapiens
111 SAT  
Two-hybrid Homo sapiens
112 CDC14B 8555
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
113 BRF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
114 CCNA2 890
Reconstituted Complex Homo sapiens
115 TOP1 7150
Affinity Capture-Western Homo sapiens
116 TP53BP1 7158
Invitro Homo sapiens
Invitro Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
117 PTEN 5728
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
118 PLAGL1  
Reconstituted Complex Homo sapiens
Phenotypic Enhancement Homo sapiens
119 PPA1 5464
Two-hybrid Homo sapiens
120 EEF2 1938
Affinity Capture-Western Homo sapiens
121 NFKBIA  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
122 PNP 4860
Two-hybrid Homo sapiens
123 TAF1B  
Invivo Homo sapiens
Invitro Homo sapiens
124 WDR33 55339
Two-hybrid Homo sapiens
125 PCAF  
Biochemical Activity Homo sapiens
126 NR3C1 2908
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
127 HMGB1 3146
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
128 FXYD6  
Two-hybrid Homo sapiens
129 EIF2S2 8894
Two-hybrid Homo sapiens
130 MDM4  
Biochemical Activity Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
131 RFC1 5981
Affinity Capture-Western Homo sapiens
132 CDC42 998
Two-hybrid Homo sapiens
133 TBP  
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
134 HNF4A  
Reconstituted Complex Homo sapiens
135 CDC25C  
Affinity Capture-MS Homo sapiens
136 SHISA5 51246
Affinity Capture-MS Homo sapiens
137 MPHOSPH6 10200
Two-hybrid Homo sapiens
138 Tmsb4x  
Two-hybrid Mus musculus
139 ARID3A  
Invivo Homo sapiens
140 TOPORS  
Invitro Homo sapiens
Two-hybrid Homo sapiens
141 CEBPZ  
Invivo Homo sapiens
Invitro Homo sapiens
142 ING5  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
143 USP7 7874
Invitro Homo sapiens
Invivo Homo sapiens
144 MGC33889  
Two-hybrid Homo sapiens
145 CSNK2B 1460
Invivo Homo sapiens
Invitro Homo sapiens
146 TP53RK 112858
Reconstituted Complex Homo sapiens
147 SULT1E1 6783
Two-hybrid Homo sapiens
148 PARP1 142
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
149 CCNG1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
150 HIPK1 204851
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
151 STK4 6789
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
152 HSPA9 3313
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
153 CHUK 1147
Invivo Homo sapiens
154 MDM2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
155 GNL3 26354
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
156 TADA3L  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
157 SUMO1 7341
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
158 HIF1A 3091
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
159 ERCC3  
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
160 YBX1 4904
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
161 SSTR3  
Invivo Homo sapiens
162 MDC1  
Affinity Capture-Western Homo sapiens
163 RRM2 6241
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
164 SMN1 6606
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
165 TAF1A  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
166 PAFAH1B3 5050
Two-hybrid Homo sapiens
167 TP53 7157
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
168 ERH 2079
Two-hybrid Homo sapiens
169 PPP1R13L 10848
Affinity Capture-Western Homo sapiens
170 GSTM4 2948
Two-hybrid Homo sapiens
171 PIN1 5300
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
172 SMARCC1 6599
Co-fractionation Homo sapiens
173 CCL18  
Two-hybrid Homo sapiens
174 RPA1 6117
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
175 HIPK3 10114
Two-hybrid Homo sapiens
176 MAPK8 5599
Invivo Homo sapiens
177 ABL1 25
Reconstituted Complex Homo sapiens
178 PTTG1  
Invivo Homo sapiens
Invitro Homo sapiens
179 HSPB1 3315
Two-hybrid Homo sapiens
180 WWOX 51741
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
181 RCHY1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
182 CDK2 1017
Biochemical Activity Homo sapiens
183 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
184 MED1 5469
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
185 CREB1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
186 SIRT1  
Affinity Capture-MS Homo sapiens
187 PLK3  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
188 CDK1 983
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
189 C16orf24  
Two-hybrid Homo sapiens
190 ESR1  
Reconstituted Complex Homo sapiens
191 BAK1 578
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
192 BTBD2  
Two-hybrid Homo sapiens
193 EFEMP2 30008
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
194 ING1  
Invitro Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
195 NCL 4691
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
196 BCL2L1 598
Affinity Capture-MS Homo sapiens
197 Banp  
Co-localization Mus musculus
Affinity Capture-Western Mus musculus
198 MAPK9 5601
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Phenotypic Suppression Homo sapiens
199 PRKCA 5578
Invivo Homo sapiens
200 ZCCHC10  
Two-hybrid Homo sapiens
201 TAF1C  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
202 STK11 6794
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
203 EP300 2033
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Suppression Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
204 HIPK2 28996
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
205 PIAS1 8554
Two-hybrid Homo sapiens
206 AR 367
Phenotypic Suppression Homo sapiens
Biochemical Activity Homo sapiens
207 TEP1 7011
Invivo Homo sapiens
Invitro Homo sapiens
208 PRMT1 3276
Reconstituted Complex Homo sapiens
209 NDN 4692
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
210 CDKN2A 1029
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
211 CRSP6  
Reconstituted Complex Homo sapiens
212 BCR 613
Two-hybrid Homo sapiens
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