Gene description for HSPA9
Gene name heat shock 70kDa protein 9 (mortalin)
Gene symbol HSPA9
Other names/aliases CRP40
CSA
GRP-75
GRP75
HEL-S-124m
HSPA9B
MOT
MOT2
MTHSP75
PBP74
Species Homo sapiens
 Database cross references - HSPA9
ExoCarta ExoCarta_3313
Vesiclepedia VP_3313
Entrez Gene 3313
HGNC 5244
MIM 600548
UniProt P38646  
 HSPA9 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 19415654    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
T lymphocytes 34108659    
 Gene ontology annotations for HSPA9
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IBA
    heat shock protein binding GO:0031072 IBA
    ubiquitin protein ligase binding GO:0031625 IPI
    protein folding chaperone GO:0044183 IBA
    unfolded protein binding GO:0051082 TAS
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    protein export from nucleus GO:0006611 IEA
    intracellular protein transport GO:0006886 NAS
    inner mitochondrial membrane organization GO:0007007 IC
    iron-sulfur cluster assembly GO:0016226 IBA
    iron-sulfur cluster assembly GO:0016226 IMP
    erythrocyte differentiation GO:0030218 IMP
    calcium import into the mitochondrion GO:0036444 ISS
    protein refolding GO:0042026 IBA
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of apoptotic process GO:0043066 TAS
    regulation of erythrocyte differentiation GO:0045646 IMP
    negative regulation of erythrocyte differentiation GO:0045647 IMP
    chaperone cofactor-dependent protein refolding GO:0051085 IBA
    negative regulation of hematopoietic stem cell differentiation GO:1902037 IEA
    negative regulation of hemopoiesis GO:1903707 IEA
Subcellular Localization
    SAM complex GO:0001401 HDA
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 TAS
    mitochondrial inner membrane GO:0005743 NAS
    TIM23 mitochondrial import inner membrane translocase complex GO:0005744 NAS
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 TAS
    focal adhesion GO:0005925 HDA
    mitochondrial nucleoid GO:0042645 IDA
    extracellular exosome GO:0070062 HDA
    MIB complex GO:0140275 HDA
 Experiment description of studies that identified HSPA9 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 65
MISEV standards
✘ Biophysical techniques
✔
HSP60|HSP27|GAPDH|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19415654    
Organism Homo sapiens
Experiment description Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7.
Authors "Staubach S, Razawi H, Hanisch FG."
Journal name PROTEOMICS
Publication year 2009
Sample Breast cancer cells
Sample name MCF-7
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
13
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
14
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
18
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
19
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
20
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
21
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
30
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
33
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
35
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
37
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
38
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
39
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
40
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
41
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
42
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
43
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
44
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
45
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
46
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for HSPA9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC13 23317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PPP1CB 5500
Co-fractionation Homo sapiens
3 UBL4A 8266
Affinity Capture-MS Homo sapiens
4 SHC1 6464
Affinity Capture-MS Homo sapiens
5 MATK  
Reconstituted Complex Homo sapiens
6 LDHB 3945
Co-fractionation Homo sapiens
7 RIN3  
Affinity Capture-MS Homo sapiens
8 SKI 6497
Affinity Capture-MS Homo sapiens
9 CRK 1398
Affinity Capture-MS Homo sapiens
10 NFATC1 4772
Affinity Capture-MS Homo sapiens
11 CAP1 10487
Co-fractionation Homo sapiens
12 DNAJB2 3300
Affinity Capture-MS Homo sapiens
13 MTG2  
Proximity Label-MS Homo sapiens
14 MAP4 4134
Co-fractionation Homo sapiens
15 C9orf78 51759
Affinity Capture-MS Homo sapiens
16 HSP90AA2P 3324
Co-fractionation Homo sapiens
17 TACC2 10579
Co-fractionation Homo sapiens
18 DDX23 9416
Cross-Linking-MS (XL-MS) Homo sapiens
19 WDR76  
Affinity Capture-MS Homo sapiens
20 PFKL 5211
Co-fractionation Homo sapiens
21 IARS2 55699
Proximity Label-MS Homo sapiens
22 DNAJC3 5611
Co-fractionation Homo sapiens
23 PPP3CB  
Affinity Capture-MS Homo sapiens
24 PSMD12 5718
Co-fractionation Homo sapiens
25 SLC9A9 285195
Affinity Capture-MS Homo sapiens
26 POU5F1  
Affinity Capture-MS Homo sapiens
27 HEXB 3074
Co-fractionation Homo sapiens
28 DNAJB1 3337
Co-fractionation Homo sapiens
29 POLR2C 5432
Proximity Label-MS Homo sapiens
30 SLC30A9 10463
Proximity Label-MS Homo sapiens
31 ARIH2 10425
Affinity Capture-MS Homo sapiens
32 SOD1 6647
Co-fractionation Homo sapiens
33 EEF1A1 1915
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
34 UNK  
Affinity Capture-RNA Homo sapiens
35 CHMP4C 92421
Affinity Capture-MS Homo sapiens
36 AURKA 6790
Affinity Capture-MS Homo sapiens
37 USP11 8237
Affinity Capture-MS Homo sapiens
38 C17orf49 124944
Affinity Capture-MS Homo sapiens
39 TNFAIP8 25816
Co-fractionation Homo sapiens
40 ESRRB  
Affinity Capture-MS Homo sapiens
41 PABPC1 26986
Co-fractionation Homo sapiens
42 CDH1 999
Affinity Capture-MS Homo sapiens
43 YAP1 10413
Affinity Capture-MS Homo sapiens
44 MYH9 4627
Co-fractionation Homo sapiens
45 TRIM21 6737
Affinity Capture-MS Homo sapiens
46 SLX4  
Affinity Capture-MS Homo sapiens
47 ALKBH3  
Affinity Capture-MS Homo sapiens
48 NOS2  
Affinity Capture-MS Homo sapiens
49 ENO1 2023
Affinity Capture-RNA Homo sapiens
50 CUL2 8453
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
51 MTRF1L  
Proximity Label-MS Homo sapiens
52 CAPN1 823
Co-fractionation Homo sapiens
53 ID2  
Affinity Capture-MS Homo sapiens
54 MTSS1L 92154
Affinity Capture-MS Homo sapiens
55 CNBP 7555
Co-fractionation Homo sapiens
56 DNAJB14  
Co-fractionation Homo sapiens
57 HSPA5 3309
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
58 HADHB 3032
Co-fractionation Homo sapiens
59 HADHA 3030
Co-fractionation Homo sapiens
60 MTIF2 4528
Proximity Label-MS Homo sapiens
61 BAG1 573
Affinity Capture-MS Homo sapiens
62 SDHA 6389
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
63 YBX1 4904
Co-fractionation Homo sapiens
64 SIRT7  
Affinity Capture-MS Homo sapiens
65 IQCB1  
Affinity Capture-MS Homo sapiens
66 PRKAR1A 5573
Co-fractionation Homo sapiens
67 PRKCZ 5590
Affinity Capture-MS Homo sapiens
68 ASS1 445
Co-fractionation Homo sapiens
69 CCT8 10694
Co-fractionation Homo sapiens
70 TBPL1 9519
Affinity Capture-MS Homo sapiens
71 EIF4E 1977
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
72 KLRG2 346689
Affinity Capture-MS Homo sapiens
73 EPRS 2058
Co-fractionation Homo sapiens
74 FN1 2335
Affinity Capture-MS Homo sapiens
75 CCNL2 81669
Affinity Capture-MS Homo sapiens
76 RPA3 6119
Proximity Label-MS Homo sapiens
77 SOHLH1  
Affinity Capture-MS Homo sapiens
78 DLST 1743
Proximity Label-MS Homo sapiens
79 CDC20 991
Affinity Capture-MS Homo sapiens
80 HSPA1A 3303
Co-fractionation Homo sapiens
81 HSPA4 3308
Co-fractionation Homo sapiens
82 STMN1 3925
Co-fractionation Homo sapiens
83 SCPEP1 59342
Co-fractionation Homo sapiens
84 AKT1 207
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
85 DLAT 1737
Proximity Label-MS Homo sapiens
86 NFATC2  
Affinity Capture-MS Homo sapiens
87 SCCPDH 51097
Co-fractionation Homo sapiens
88 PFAS 5198
Co-fractionation Homo sapiens
89 STUB1 10273
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
90 HSPE1 3336
Co-fractionation Homo sapiens
91 CPEB4  
Affinity Capture-MS Homo sapiens
92 GLS 2744
Proximity Label-MS Homo sapiens
93 CCDC58 131076
Co-fractionation Homo sapiens
94 FASN 2194
Co-fractionation Homo sapiens
95 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
96 CLPX 10845
Proximity Label-MS Homo sapiens
97 GRB2 2885
Affinity Capture-MS Homo sapiens
98 PSAT1 29968
Cross-Linking-MS (XL-MS) Homo sapiens
99 ZEB1  
Affinity Capture-MS Homo sapiens
100 NME4 4833
Proximity Label-MS Homo sapiens
101 COX5A 9377
Co-fractionation Homo sapiens
102 TKT 7086
Co-fractionation Homo sapiens
103 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
104 SIRT1  
Affinity Capture-MS Homo sapiens
105 SSBP1 6742
Co-fractionation Homo sapiens
106 DDX3X 1654
Affinity Capture-MS Homo sapiens
107 GAPDH 2597
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
108 ALYREF 10189
Co-fractionation Homo sapiens
109 HNRNPL 3191
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
110 SUPT6H 6830
Reconstituted Complex Homo sapiens
111 PSMA7 5688
Co-fractionation Homo sapiens
112 ACOT1 641371
Proximity Label-MS Homo sapiens
113 ITPA 3704
Co-fractionation Homo sapiens
114 CLTA 1211
Affinity Capture-MS Homo sapiens
115 ACO2 50
Affinity Capture-MS Homo sapiens
116 AIMP1 9255
Co-fractionation Homo sapiens
117 CUL7 9820
Affinity Capture-MS Homo sapiens
118 ADRM1 11047
Co-fractionation Homo sapiens
119 NHSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 NDUFS6  
Proximity Label-MS Homo sapiens
121 PTPRF 5792
Two-hybrid Homo sapiens
122 LDHA 3939
Co-fractionation Homo sapiens
123 AFG3L2 10939
Proximity Label-MS Homo sapiens
124 SMC3 9126
Cross-Linking-MS (XL-MS) Homo sapiens
125 NCBP1 4686
Co-fractionation Homo sapiens
126 SPRTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 HSPA6 3310
Co-fractionation Homo sapiens
128 GJA1 2697
Affinity Capture-MS Homo sapiens
129 BTF3 689
Affinity Capture-MS Homo sapiens
130 CRYL1 51084
Affinity Capture-MS Homo sapiens
131 ADRB2  
Affinity Capture-MS Homo sapiens
132 DTNA  
Affinity Capture-MS Homo sapiens
133 NDUFA12 55967
Proximity Label-MS Homo sapiens
134 CREM  
Affinity Capture-MS Homo sapiens
135 CAND1 55832
Affinity Capture-MS Homo sapiens
136 CLUH 23277
Proximity Label-MS Homo sapiens
137 UBXN2A  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
138 MRPL44  
Proximity Label-MS Homo sapiens
139 NDUFS2 4720
Proximity Label-MS Homo sapiens
140 DNAJB6 10049
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 WTAP 9589
Affinity Capture-MS Homo sapiens
142 PGK1 5230
Cross-Linking-MS (XL-MS) Homo sapiens
143 OGDH 4967
Proximity Label-MS Homo sapiens
144 HSPA2 3306
Co-fractionation Homo sapiens
145 COPS6 10980
Affinity Capture-MS Homo sapiens
146 NDUFA5 4698
Proximity Label-MS Homo sapiens
147 NPM1 4869
Co-fractionation Homo sapiens
148 KHDRBS1 10657
Co-fractionation Homo sapiens
149 OBSL1 23363
Affinity Capture-MS Homo sapiens
150 HSPH1 10808
Co-fractionation Homo sapiens
151 NR4A1  
Affinity Capture-MS Homo sapiens
152 ERAL1  
Proximity Label-MS Homo sapiens
153 C9orf142  
Affinity Capture-MS Homo sapiens
154 VCAM1 7412
Affinity Capture-MS Homo sapiens
155 DDX6 1656
Co-fractionation Homo sapiens
156 ETFA 2108
Proximity Label-MS Homo sapiens
157 FOXD4  
Affinity Capture-MS Homo sapiens
158 CTPS1 1503
Co-fractionation Homo sapiens
159 CUL1 8454
Affinity Capture-MS Homo sapiens
160 LRRC36  
Affinity Capture-MS Homo sapiens
161 C2orf68  
Affinity Capture-MS Homo sapiens
162 MRPS35 60488
Proximity Label-MS Homo sapiens
163 DNAJB8 165721
Affinity Capture-MS Homo sapiens
164 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
165 USP10 9100
Affinity Capture-MS Homo sapiens
166 RBX1 9978
Co-fractionation Homo sapiens
167 CDKN1A  
Affinity Capture-MS Homo sapiens
168 RLIM 51132
Affinity Capture-MS Homo sapiens
169 ABHD14A  
Co-fractionation Homo sapiens
170 PSMD14 10213
Affinity Capture-MS Homo sapiens
171 CBL 867
Affinity Capture-MS Homo sapiens
172 AHNAK 79026
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
173 VRK1 7443
Affinity Capture-MS Homo sapiens
174 PLK1 5347
Affinity Capture-MS Homo sapiens
175 NCL 4691
Co-fractionation Homo sapiens
176 MAGOH 4116
Affinity Capture-MS Homo sapiens
177 IARS 3376
Co-fractionation Homo sapiens
178 TTC25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 Ksr1  
Affinity Capture-MS Mus musculus
180 CYLD  
Affinity Capture-MS Homo sapiens
181 GTF2A1 2957
Affinity Capture-MS Homo sapiens
182 FBXL4 26235
Affinity Capture-MS Homo sapiens
183 HNRNPD 3184
Co-fractionation Homo sapiens
184 MRM1  
Affinity Capture-MS Homo sapiens
185 PTPN11 5781
Reconstituted Complex Homo sapiens
186 PSMA3 5684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 AIFM1 9131
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
188 ICAM1 3383
Co-fractionation Homo sapiens
189 XPO1 7514
Two-hybrid Homo sapiens
190 EIF6 3692
Co-fractionation Homo sapiens
191 RC3H2  
Affinity Capture-MS Homo sapiens
192 IKZF3  
Affinity Capture-MS Homo sapiens
193 PPA1 5464
Co-fractionation Homo sapiens
194 TXNRD1 7296
Co-fractionation Homo sapiens
195 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 HSD17B10 3028
Co-fractionation Homo sapiens
197 FUS 2521
Affinity Capture-MS Homo sapiens
198 IKZF1  
Affinity Capture-MS Homo sapiens
199 LARS 51520
Co-fractionation Homo sapiens
200 G6PD 2539
Co-fractionation Homo sapiens
201 GINS3  
Co-fractionation Homo sapiens
202 CDK2 1017
Affinity Capture-MS Homo sapiens
203 CEP250 11190
Affinity Capture-MS Homo sapiens
204 PPP2R1A 5518
Co-fractionation Homo sapiens
205 HS3ST3B1 9953
Affinity Capture-MS Homo sapiens
206 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
207 ACAD9 28976
Proximity Label-MS Homo sapiens
208 DDB1 1642
Co-fractionation Homo sapiens
209 DDRGK1 65992
Affinity Capture-MS Homo sapiens
210 RHOB 388
Proximity Label-MS Homo sapiens
211 NELFB 25920
Reconstituted Complex Homo sapiens
212 SIRT3  
Affinity Capture-MS Homo sapiens
213 MCUR1 63933
Proximity Label-MS Homo sapiens
214 HUWE1 10075
Affinity Capture-MS Homo sapiens
215 EIF3H 8667
Affinity Capture-MS Homo sapiens
216 DSP 1832
Co-fractionation Homo sapiens
217 CLPP 8192
Proximity Label-MS Homo sapiens
218 CS 1431
Proximity Label-MS Homo sapiens
219 C17orf80 55028
Proximity Label-MS Homo sapiens
220 SPOP  
Affinity Capture-MS Homo sapiens
221 HDGF 3068
Affinity Capture-MS Homo sapiens
222 ATXN3 4287
Affinity Capture-MS Homo sapiens
223 HMGB1 3146
Cross-Linking-MS (XL-MS) Homo sapiens
224 SLK 9748
Cross-Linking-MS (XL-MS) Homo sapiens
225 FOLR1 2348
Affinity Capture-MS Homo sapiens
226 PRKCI 5584
Co-fractionation Homo sapiens
227 PTBP1 5725
Co-fractionation Homo sapiens
228 FKBP4 2288
Co-fractionation Homo sapiens
229 COX8A  
Proximity Label-MS Homo sapiens
230 OTUB1 55611
Affinity Capture-MS Homo sapiens
231 SHMT2 6472
Affinity Capture-RNA Homo sapiens
Proximity Label-MS Homo sapiens
232 RNF38  
Affinity Capture-MS Homo sapiens
233 TEFM  
Proximity Label-MS Homo sapiens
234 DNAJB4 11080
Co-fractionation Homo sapiens
235 ATG3 64422
Co-fractionation Homo sapiens
236 C1QBP 708
Affinity Capture-MS Homo sapiens
237 CDKN2A 1029
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
238 SPINK7  
Affinity Capture-MS Homo sapiens
239 KRAS 3845
Affinity Capture-MS Homo sapiens
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
240 MYC  
Affinity Capture-MS Homo sapiens
241 PRMT1 3276
Affinity Capture-MS Homo sapiens
242 MRPS9 64965
Proximity Label-MS Homo sapiens
243 CUL4A 8451
Affinity Capture-MS Homo sapiens
244 MAP1LC3C  
Affinity Capture-Western Homo sapiens
245 RAB1A 5861
Co-fractionation Homo sapiens
246 DNAJC8 22826
Co-fractionation Homo sapiens
247 NDUFS1 4719
Proximity Label-MS Homo sapiens
248 SP1  
Affinity Capture-MS Homo sapiens
249 DNAJA4 55466
Co-fractionation Homo sapiens
250 EPS15 2060
Affinity Capture-MS Homo sapiens
251 PYCR1 5831
Cross-Linking-MS (XL-MS) Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
252 CCDC9  
Affinity Capture-MS Homo sapiens
253 PSMD10 5716
Co-fractionation Homo sapiens
254 RPS6KB2  
Affinity Capture-MS Homo sapiens
255 ZNF414  
Affinity Capture-MS Homo sapiens
256 LRPPRC 10128
Proximity Label-MS Homo sapiens
257 CAPZB 832
Affinity Capture-MS Homo sapiens
258 NDUFS3 4722
Proximity Label-MS Homo sapiens
259 DENND2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
260 MCM2 4171
Affinity Capture-MS Homo sapiens
261 HINT2 84681
Proximity Label-MS Homo sapiens
262 QARS 5859
Co-fractionation Homo sapiens
263 CKAP5 9793
Affinity Capture-MS Homo sapiens
264 NDUFV1 4723
Proximity Label-MS Homo sapiens
265 ATG16L1 55054
Affinity Capture-MS Homo sapiens
266 GPN1  
Affinity Capture-MS Homo sapiens
267 MAVS 57506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
268 TFCP2 7024
Affinity Capture-MS Homo sapiens
269 PABPC4 8761
Co-fractionation Homo sapiens
270 HSPA8 3312
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
271 INSIG2  
Affinity Capture-MS Homo sapiens
272 NANOG  
Affinity Capture-MS Homo sapiens
273 HSPBP1 23640
Reconstituted Complex Homo sapiens
274 NF2 4771
Affinity Capture-MS Homo sapiens
275 NDUFV2 4729
Proximity Label-MS Homo sapiens
276 S100A2 6273
Co-fractionation Homo sapiens
277 ATP5A1 498
Co-fractionation Homo sapiens
278 DNLZ  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
279 CUL4B 8450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
280 PARK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
281 RPS10 6204
Co-fractionation Homo sapiens
282 MARS 4141
Co-fractionation Homo sapiens
283 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
284 CAST 831
Co-fractionation Homo sapiens
285 CBX3 11335
Co-fractionation Homo sapiens
286 SLAIN1 122060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
287 RPA2 6118
Proximity Label-MS Homo sapiens
288 RAN 5901
Co-fractionation Homo sapiens
289 RRM1 6240
Co-fractionation Homo sapiens
290 NTRK1 4914
Affinity Capture-MS Homo sapiens
291 U2AF2 11338
Affinity Capture-MS Homo sapiens
292 DNAJA1 3301
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
293 FLNB 2317
Co-fractionation Homo sapiens
294 ACTB 60
Co-fractionation Homo sapiens
295 VCPKMT  
Affinity Capture-MS Homo sapiens
296 AQP12B  
Affinity Capture-MS Homo sapiens
297 NDUFV3 4731
Proximity Label-MS Homo sapiens
298 HDAC5 10014
Affinity Capture-MS Homo sapiens
299 PURB 5814
Co-fractionation Homo sapiens
300 GPRC5A 9052
Co-fractionation Homo sapiens
301 OGT 8473
Reconstituted Complex Homo sapiens
302 LSM8 51691
Two-hybrid Homo sapiens
303 KIAA1191  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
304 MINOS1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
305 METTL14  
Affinity Capture-MS Homo sapiens
306 DNAJB12 54788
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
307 TRMT10C 54931
Proximity Label-MS Homo sapiens
308 DHX15 1665
Co-fractionation Homo sapiens
309 TRAF3IP1 26146
Affinity Capture-MS Homo sapiens
310 FERMT2 10979
Co-fractionation Homo sapiens
311 C19orf43  
Co-fractionation Homo sapiens
312 PSMD6 9861
Co-fractionation Homo sapiens
313 METTL21A  
Affinity Capture-MS Homo sapiens
314 SIRPA 140885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
315 DIRAS2 54769
Affinity Capture-MS Homo sapiens
316 NR3C1 2908
Affinity Capture-MS Homo sapiens
317 DNAJC17  
Co-fractionation Homo sapiens
318 OSGEP 55644
Co-fractionation Homo sapiens
319 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
320 TP73  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
321 RCN1 5954
Cross-Linking-MS (XL-MS) Homo sapiens
322 AP2M1 1173
Affinity Capture-MS Homo sapiens
323 NDUFA2 4695
Proximity Label-MS Homo sapiens
324 GPX7 2882
Affinity Capture-MS Homo sapiens
325 BICD1 636
Proximity Label-MS Homo sapiens
326 LIME1 54923
Affinity Capture-MS Homo sapiens
327 HAX1  
Affinity Capture-MS Homo sapiens
328 MSN 4478
Co-fractionation Homo sapiens
329 ILF3 3609
Co-fractionation Homo sapiens
330 TPM3 7170
Co-fractionation Homo sapiens
331 SDHAF2 54949
Affinity Capture-MS Homo sapiens
332 DNAJC4  
Affinity Capture-MS Homo sapiens
333 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
334 PHB2 11331
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
335 MRPS7 51081
Proximity Label-MS Homo sapiens
336 TSFM 10102
Proximity Label-MS Homo sapiens
337 TP53 7157
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
338 FBXL6  
Affinity Capture-MS Homo sapiens
339 COPZ2 51226
Affinity Capture-MS Homo sapiens
340 ICT1 3396
Affinity Capture-MS Homo sapiens
341 MCM5 4174
Affinity Capture-MS Homo sapiens
342 PRRC2C 23215
Co-fractionation Homo sapiens
343 PDHA1 5160
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
344 HNRNPM 4670
Co-fractionation Homo sapiens
345 G3BP1 10146
Co-fractionation Homo sapiens
346 HSPB1 3315
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
347 GRPEL1 80273
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
348 PLOD1 5351
Co-fractionation Homo sapiens
349 GNB1 2782
Co-fractionation Homo sapiens
350 MYL12A 10627
Co-fractionation Homo sapiens
351 TRAP1 10131
Cross-Linking-MS (XL-MS) Homo sapiens
352 EEF2 1938
Co-fractionation Homo sapiens
353 UFL1 23376
Affinity Capture-MS Homo sapiens
354 NDUFS8 4728
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
355 TBRG4 9238
Proximity Label-MS Homo sapiens
356 AARS2  
Proximity Label-MS Homo sapiens
357 LRRK2 120892
Affinity Capture-MS Homo sapiens
358 NEDD1 121441
Affinity Capture-MS Homo sapiens
359 RAB7A 7879
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
360 HNRNPF 3185
Co-fractionation Homo sapiens
361 SPG20 23111
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
362 SERBP1 26135
Affinity Capture-MS Homo sapiens
363 AR 367
Affinity Capture-MS Homo sapiens
364 RC3H1 149041
Affinity Capture-MS Homo sapiens
365 MTL5  
Affinity Capture-MS Homo sapiens
366 CACYBP 27101
Co-fractionation Homo sapiens
367 TIMM44 10469
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
368 EP300 2033
Affinity Capture-MS Homo sapiens
369 EIF5 1983
Co-fractionation Homo sapiens
370 UBE2H 7328
Affinity Capture-MS Homo sapiens
371 INSIG1  
Affinity Capture-MS Homo sapiens
372 SLFN11 91607
Affinity Capture-MS Homo sapiens
373 RIT1 6016
Negative Genetic Homo sapiens
374 CUEDC2  
Cross-Linking-MS (XL-MS) Homo sapiens
375 FAM167A  
Affinity Capture-MS Homo sapiens
376 PSMD11 5717
Co-fractionation Homo sapiens
377 POFUT1 23509
Co-fractionation Homo sapiens
378 BZW2 28969
Co-fractionation Homo sapiens
379 FBXO25  
Affinity Capture-MS Homo sapiens
380 PBK  
Co-fractionation Homo sapiens
381 MED9  
Affinity Capture-MS Homo sapiens
382 ETFB 2109
Proximity Label-MS Homo sapiens
383 KARS 3735
Co-fractionation Homo sapiens
384 TROVE2 6738
Co-fractionation Homo sapiens
385 RPUSD4 84881
Proximity Label-MS Homo sapiens
386 CFL1 1072
Co-fractionation Homo sapiens
387 DNAJB3 414061
Affinity Capture-MS Homo sapiens
388 APP 351
Reconstituted Complex Homo sapiens
389 KIAA1429 25962
Affinity Capture-MS Homo sapiens
390 PRDX3 10935
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
391 TGFB1 7040
Affinity Capture-MS Homo sapiens
392 COPS5 10987
Affinity Capture-MS Homo sapiens
393 AGO3  
Affinity Capture-MS Homo sapiens
394 YWHAG 7532
Affinity Capture-MS Homo sapiens
395 ATP5O 539
Co-fractionation Homo sapiens
396 MLLT6  
Affinity Capture-MS Homo sapiens
397 EED  
Affinity Capture-MS Homo sapiens
398 CEP57  
Affinity Capture-MS Homo sapiens
399 CDC73  
Affinity Capture-MS Homo sapiens
400 PRCC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
401 KISS1  
Affinity Capture-MS Homo sapiens
402 MYCN  
Affinity Capture-MS Homo sapiens
403 DAP3 7818
Proximity Label-MS Homo sapiens
404 HSPD1 3329
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
405 DVL2 1856
Affinity Capture-MS Homo sapiens
406 STOML2 30968
Co-fractionation Homo sapiens
407 GARS 2617
Co-fractionation Homo sapiens
408 HAUS2  
Affinity Capture-MS Homo sapiens
409 PRDM1  
Affinity Capture-MS Homo sapiens
410 DUT 1854
Co-fractionation Homo sapiens
411 PSMC1 5700
Co-fractionation Homo sapiens
412 STAU1 6780
Affinity Capture-MS Homo sapiens
413 CPS1 1373
Co-fractionation Homo sapiens
414 RNF146  
Affinity Capture-MS Homo sapiens
415 BZLF1  
Affinity Capture-MS
416 PTCD3 55037
Proximity Label-MS Homo sapiens
417 VCL 7414
Co-fractionation Homo sapiens
418 IFI16 3428
Affinity Capture-MS Homo sapiens
419 SUMO2 6613
Reconstituted Complex Homo sapiens
420 AIP 9049
Co-fractionation Homo sapiens
421 LYRM4 57128
Co-fractionation Homo sapiens
422 BRAF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
423 CEP76  
Affinity Capture-MS Homo sapiens
424 DNAJC30  
Affinity Capture-MS Homo sapiens
425 CEBPA  
Proximity Label-MS Homo sapiens
426 ATP5B 506
Co-fractionation Homo sapiens
427 MAT2A 4144
Co-fractionation Homo sapiens
428 PHB 5245
Co-fractionation Homo sapiens
429 BCAP31 10134
Co-fractionation Homo sapiens
430 GAN 8139
Affinity Capture-MS Homo sapiens
431 RAP1GDS1 5910
Co-fractionation Homo sapiens
432 GOLGA3 2802
Co-fractionation Homo sapiens
433 GAPVD1 26130
Co-fractionation Homo sapiens
434 MRRF  
Proximity Label-MS Homo sapiens
435 FANCD2  
Affinity Capture-MS Homo sapiens
436 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
437 CDK9 1025
Affinity Capture-MS Homo sapiens
438 NDUFA9 4704
Proximity Label-MS Homo sapiens
439 PSMD13 5719
Co-fractionation Homo sapiens
440 LETM1 3954
Proximity Label-MS Homo sapiens
441 CTNNB1 1499
Affinity Capture-MS Homo sapiens
442 HCFC1 3054
Co-fractionation Homo sapiens
443 YKT6 10652
Two-hybrid Homo sapiens
444 CTTN 2017
Co-fractionation Homo sapiens
445 PDIA3 2923
Co-fractionation Homo sapiens
446 ELAC2 60528
Proximity Label-MS Homo sapiens
447 GAA 2548
Co-fractionation Homo sapiens
448 BAP1 8314
Co-purification Homo sapiens
449 PYCR2 29920
Proximity Label-MS Homo sapiens
450 PSMD7 5713
Co-fractionation Homo sapiens
451 ECHS1 1892
Co-fractionation Homo sapiens
452 SART1 9092
Co-fractionation Homo sapiens
453 NXF1 10482
Affinity Capture-RNA Homo sapiens
454 AURKB 9212
Affinity Capture-MS Homo sapiens
455 PMPCB 9512
Proximity Label-MS Homo sapiens
456 PRKACA 5566
Co-fractionation Homo sapiens
457 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
458 FBXO6 26270
Affinity Capture-MS Homo sapiens
459 HYI 81888
Co-fractionation Homo sapiens
460 DNAJC9 23234
Co-fractionation Homo sapiens
461 NFKB1 4790
Co-fractionation Homo sapiens
462 VARS2  
Proximity Label-MS Homo sapiens
463 HSPA4L 22824
Co-fractionation Homo sapiens
464 ZC2HC1C  
Affinity Capture-MS Homo sapiens
465 RARS 5917
Co-fractionation Homo sapiens
466 GNB2L1 10399
Co-fractionation Homo sapiens
467 CCDC8  
Affinity Capture-MS Homo sapiens
468 H2AFX 3014
Affinity Capture-MS Homo sapiens
469 CPNE3 8895
Co-fractionation Homo sapiens
470 TRIP6 7205
Co-fractionation Homo sapiens
471 GRPEL2  
Co-fractionation Homo sapiens
472 ADAT3 113179
Affinity Capture-MS Homo sapiens
473 MVD 4597
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
474 DNAJC19 131118
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
475 TUBG1 7283
Affinity Capture-MS Homo sapiens
476 INPPL1 3636
Affinity Capture-MS Homo sapiens
477 DNAJA2 10294
Co-fractionation Homo sapiens
478 MRPS31  
Proximity Label-MS Homo sapiens
479 CUL5 8065
Affinity Capture-MS Homo sapiens
480 PDCD6 10016
Co-fractionation Homo sapiens
481 DNAJA3 9093
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
482 SMURF1 57154
Affinity Capture-MS Homo sapiens
483 NDUFS7 374291
Proximity Label-MS Homo sapiens
484 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
485 CHD4 1108
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
486 EIF4A3 9775
Affinity Capture-MS Homo sapiens
487 NUP35 129401
Proximity Label-MS Homo sapiens
488 SFXN1 94081
Proximity Label-MS Homo sapiens
489 SP6  
Affinity Capture-MS Homo sapiens
490 GSTM3 2947
Co-fractionation Homo sapiens
491 MOV10 4343
Affinity Capture-RNA Homo sapiens
492 PCBP1 5093
Co-fractionation Homo sapiens
493 ARRB1 408
Affinity Capture-MS Homo sapiens
494 TRIM31  
Affinity Capture-MS Homo sapiens
495 PINK1  
Affinity Capture-MS Homo sapiens
496 CYB5R3 1727
Co-fractionation Homo sapiens
497 GRSF1 2926
Affinity Capture-MS Homo sapiens
498 XRCC6 2547
Proximity Label-MS Homo sapiens
499 DNAJC1 64215
Co-fractionation Homo sapiens
500 HNRNPU 3192
Co-fractionation Homo sapiens
501 C9orf72  
Affinity Capture-MS Homo sapiens
502 WARS 7453
Co-fractionation Homo sapiens
503 IRF2BP2  
Cross-Linking-MS (XL-MS) Homo sapiens
504 FGF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
505 NEDD8 4738
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here