Gene description for UBL4A
Gene name ubiquitin-like 4A
Gene symbol UBL4A
Other names/aliases DX254E
DXS254E
G6PD
GDX
GET5
MDY2
TMA24
UBL4
Species Homo sapiens
 Database cross references - UBL4A
ExoCarta ExoCarta_8266
Vesiclepedia VP_8266
Entrez Gene 8266
HGNC 12505
MIM 312070
UniProt P11441  
 UBL4A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for UBL4A
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-like protein transferase activity GO:0019787 TAS
    protein-folding chaperone binding GO:0051087 IBA
    protein-folding chaperone binding GO:0051087 IPI
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    post-translational protein targeting to endoplasmic reticulum membrane GO:0006620 IBA
    post-translational protein targeting to endoplasmic reticulum membrane GO:0006620 IDA
    regulation of protein stability GO:0031647 IDA
    protein modification process GO:0036211 TAS
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IBA
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IDA
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 NAS
    membrane GO:0016020 IDA
    BAT3 complex GO:0071818 IBA
    BAT3 complex GO:0071818 IDA
    BAT3 complex GO:0071818 IPI
 Experiment description of studies that identified UBL4A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UBL4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
3 CCAR1 55749
Affinity Capture-MS Homo sapiens
4 RPS12 6206
Affinity Capture-MS Homo sapiens
5 HACD3 51495
Affinity Capture-MS Homo sapiens
6 RPSA 3921
Affinity Capture-MS Homo sapiens
7 HNRNPC 3183
Affinity Capture-MS Homo sapiens
8 P4HA1 5033
Affinity Capture-MS Homo sapiens
9 PQBP1  
Co-fractionation Homo sapiens
10 SPIN1  
Affinity Capture-MS Homo sapiens
11 NCBP1 4686
Affinity Capture-MS Homo sapiens
12 NPLOC4 55666
Affinity Capture-MS Homo sapiens
13 RPS20 6224
Affinity Capture-MS Homo sapiens
14 C11orf84  
Affinity Capture-MS Homo sapiens
15 RAB1A 5861
Affinity Capture-MS Homo sapiens
16 HSPA6 3310
Affinity Capture-MS Homo sapiens
17 FAM20B 9917
Affinity Capture-MS Homo sapiens
18 PAEP  
Affinity Capture-MS Homo sapiens
19 RPL13 6137
Affinity Capture-MS Homo sapiens
20 USP13  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
21 RPL30 6156
Affinity Capture-MS Homo sapiens
22 TUBB4B 10383
Affinity Capture-MS Homo sapiens
23 SRPRB 58477
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
24 RAB15 376267
Affinity Capture-MS Homo sapiens
25 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
26 Gtf2b  
Affinity Capture-MS Mus musculus
27 RPL7 6129
Affinity Capture-MS Homo sapiens
28 KPNB1 3837
Affinity Capture-MS Homo sapiens
29 ACTC1 70
Affinity Capture-MS Homo sapiens
30 TUBB8 347688
Affinity Capture-MS Homo sapiens
31 RPL37A 6168
Affinity Capture-MS Homo sapiens
32 HSPA1L 3305
Affinity Capture-MS Homo sapiens
33 RPS19 6223
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
34 SURF4 6836
Affinity Capture-MS Homo sapiens
35 RPL15 6138
Affinity Capture-MS Homo sapiens
36 C1QBP 708
Affinity Capture-MS Homo sapiens
37 TRA  
Affinity Capture-Western Homo sapiens
38 RPL14 9045
Affinity Capture-MS Homo sapiens
39 RPL12 6136
Affinity Capture-MS Homo sapiens
40 KPNA2 3838
Affinity Capture-MS Homo sapiens
41 HNRNPR 10236
Affinity Capture-MS Homo sapiens
42 NDUFA4 4697
Affinity Capture-MS Homo sapiens
43 STX4 6810
Affinity Capture-MS Homo sapiens
44 HSD17B12 51144
Affinity Capture-MS Homo sapiens
45 SNRPD2 6633
Affinity Capture-MS Homo sapiens
46 APP 351
Reconstituted Complex Homo sapiens
47 TRIM54  
Two-hybrid Homo sapiens
48 UFD1L 7353
Affinity Capture-MS Homo sapiens
49 ILF2 3608
Affinity Capture-MS Homo sapiens
50 UBE2G2  
Affinity Capture-MS Homo sapiens
51 CDCA7L  
Two-hybrid Homo sapiens
52 RAB1C 441400
Affinity Capture-MS Homo sapiens
53 VPS26A 9559
Affinity Capture-MS Homo sapiens
54 CD320 51293
Affinity Capture-MS Homo sapiens
55 RPS6 6194
Affinity Capture-MS Homo sapiens
56 RPL4 6124
Affinity Capture-MS Homo sapiens
57 RPL10A 4736
Affinity Capture-MS Homo sapiens
58 SNRNP70 6625
Affinity Capture-MS Homo sapiens
59 ERLIN2 11160
Affinity Capture-MS Homo sapiens
60 RPL7A 6130
Affinity Capture-MS Homo sapiens
61 HSPA2 3306
Affinity Capture-MS Homo sapiens
62 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
63 WDR20 91833
Affinity Capture-MS Homo sapiens
64 TUBA1C 84790
Affinity Capture-MS Homo sapiens
65 NDUFA7 4701
Co-fractionation Homo sapiens
66 ACTG2 72
Affinity Capture-MS Homo sapiens
67 RPLP1 6176
Affinity Capture-MS Homo sapiens
68 RPL24 6152
Affinity Capture-MS Homo sapiens
69 CPD 1362
Affinity Capture-MS Homo sapiens
70 UBL4B  
Affinity Capture-MS Homo sapiens
71 STX7 8417
Affinity Capture-MS Homo sapiens
72 NPM1 4869
Affinity Capture-MS Homo sapiens
73 DUSP2  
Affinity Capture-MS Homo sapiens
74 RER1 11079
Affinity Capture-MS Homo sapiens
75 RPS9 6203
Affinity Capture-MS Homo sapiens
76 UBQLN1 29979
Affinity Capture-MS Homo sapiens
77 RPLP2 6181
Affinity Capture-MS Homo sapiens
78 MRPS22 56945
Affinity Capture-MS Homo sapiens
79 ATP5O 539
Affinity Capture-MS Homo sapiens
80 Myh9 17886
Affinity Capture-MS Mus musculus
81 USMG5 84833
Affinity Capture-MS Homo sapiens
82 RPL38 6169
Affinity Capture-MS Homo sapiens
83 FAF1 11124
Affinity Capture-MS Homo sapiens
84 SARNP 84324
Co-fractionation Homo sapiens
85 STXBP3 6814
Affinity Capture-MS Homo sapiens
86 TUBA3C 7278
Affinity Capture-MS Homo sapiens
87 PHB 5245
Affinity Capture-MS Homo sapiens
88 PRDX4 10549
Affinity Capture-MS Homo sapiens
89 RAB8B 51762
Affinity Capture-MS Homo sapiens
90 RPS3A 6189
Affinity Capture-MS Homo sapiens
91 ATP5H 10476
Affinity Capture-MS Homo sapiens
92 RPL34 6164
Affinity Capture-MS Homo sapiens
93 METTL23  
Affinity Capture-MS Homo sapiens
94 PXMP2  
Proximity Label-MS Homo sapiens
95 RNF126  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
96 FAF2 23197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 DHCR24 1718
Affinity Capture-MS Homo sapiens
98 KIF21A 55605
Affinity Capture-MS Homo sapiens
99 EEF1A1 1915
Affinity Capture-MS Homo sapiens
100 SLC25A3 5250
Affinity Capture-MS Homo sapiens
101 HSPA8 3312
Affinity Capture-MS Homo sapiens
102 RAB1B 81876
Affinity Capture-MS Homo sapiens
103 TRAF4 9618
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
104 PHB2 11331
Affinity Capture-MS Homo sapiens
105 SNRPE 6635
Affinity Capture-MS Homo sapiens
106 RB1 5925
Affinity Capture-MS Homo sapiens
107 LDHB 3945
Affinity Capture-MS Homo sapiens
108 ACTA2 59
Affinity Capture-MS Homo sapiens
109 GEMIN5 25929
Affinity Capture-MS Homo sapiens
110 PPIB 5479
Co-fractionation Homo sapiens
111 FOXA1  
Affinity Capture-MS Homo sapiens
112 MAPK3 5595
Affinity Capture-MS Homo sapiens
113 RPL13A 23521
Affinity Capture-MS Homo sapiens
114 DIABLO 56616
Affinity Capture-MS Homo sapiens
115 RPL9 6133
Affinity Capture-MS Homo sapiens
116 RPL26 6154
Affinity Capture-MS Homo sapiens
117 RAB14 51552
Affinity Capture-MS Homo sapiens
118 MYEOV  
Affinity Capture-MS Homo sapiens
119 RPL5 6125
Affinity Capture-MS Homo sapiens
120 PARK2  
Affinity Capture-MS Homo sapiens
121 DUT 1854
Co-fractionation Homo sapiens
122 AMFR 267
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
123 RPS10 6204
Affinity Capture-MS Homo sapiens
124 CLNS1A 1207
Affinity Capture-MS Homo sapiens
125 TUBA1A 7846
Affinity Capture-MS Homo sapiens
126 ILVBL 10994
Affinity Capture-MS Homo sapiens
127 PLOD2 5352
Affinity Capture-MS Homo sapiens
128 BAG6 7917
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 TUFM 7284
Affinity Capture-MS Homo sapiens
130 RPL32 6161
Affinity Capture-MS Homo sapiens
131 ASNA1 439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 FAM162A 26355
Affinity Capture-MS Homo sapiens
133 Ube2k 53323
Affinity Capture-MS Mus musculus
134 RPS6KB1 6198
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 DDX20 11218
Affinity Capture-MS Homo sapiens
136 PABPC1 26986
Affinity Capture-MS Homo sapiens
137 TUBA1B 10376
Affinity Capture-MS Homo sapiens
138 APOL2 23780
Affinity Capture-MS Homo sapiens
139 YWHAE 7531
Affinity Capture-MS Homo sapiens
140 VCP 7415
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
141 Inpp5b  
Affinity Capture-MS Mus musculus
142 RPL31 6160
Affinity Capture-MS Homo sapiens
143 RPS25 6230
Affinity Capture-MS Homo sapiens
144 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
145 EEF2 1938
Affinity Capture-MS Homo sapiens
146 NDUFA2 4695
Co-fractionation Homo sapiens
147 MEOX2  
Two-hybrid Homo sapiens
148 P4HB 5034
Affinity Capture-MS Homo sapiens
149 RPL27A 6157
Affinity Capture-MS Homo sapiens
150 ACTB 60
Affinity Capture-MS Homo sapiens
151 SERPINH1 871
Co-fractionation Homo sapiens
152 ANAPC4 29945
Affinity Capture-MS Homo sapiens
153 DNAJC5G  
Proximity Label-MS Homo sapiens
154 HNRNPL 3191
Affinity Capture-MS Homo sapiens
155 TECR 9524
Affinity Capture-MS Homo sapiens
156 SNRPD3 6634
Affinity Capture-MS Homo sapiens
157 RAB10 10890
Affinity Capture-MS Homo sapiens
158 PRPF31 26121
Affinity Capture-MS Homo sapiens
159 NCL 4691
Affinity Capture-MS Homo sapiens
160 GET4 51608
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 ACTG1 71
Affinity Capture-MS Homo sapiens
162 SEC61B 10952
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
163 ATP5B 506
Affinity Capture-MS Homo sapiens
164 TMED1 11018
Affinity Capture-MS Homo sapiens
165 RPL29 6159
Affinity Capture-MS Homo sapiens
166 Asna1 56495
Affinity Capture-MS Mus musculus
167 OGT 8473
Affinity Capture-MS Homo sapiens
168 CDIPT 10423
Affinity Capture-MS Homo sapiens
169 SSR4 6748
Affinity Capture-MS Homo sapiens
170 RPL27 6155
Affinity Capture-MS Homo sapiens
171 ZRANB1 54764
Affinity Capture-MS Homo sapiens
172 BCAP31 10134
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 PDE12 201626
Affinity Capture-MS Homo sapiens
174 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 ACAT1 38
Co-fractionation Homo sapiens
176 ZBTB2 57621
Affinity Capture-MS Homo sapiens
177 TUBB 203068
Affinity Capture-MS Homo sapiens
178 SRPR 6734
Affinity Capture-MS Homo sapiens
179 TMED9 54732
Affinity Capture-MS Homo sapiens
180 SUGP1  
Co-fractionation Homo sapiens
181 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 RPL10 6134
Affinity Capture-MS Homo sapiens
183 CANX 821
Affinity Capture-MS Homo sapiens
184 RAB7A 7879
Affinity Capture-MS Homo sapiens
185 RPS2 6187
Affinity Capture-MS Homo sapiens
186 AMBRA1  
Affinity Capture-MS Homo sapiens
187 LRRC59 55379
Affinity Capture-MS Homo sapiens
188 ARRDC4  
Affinity Capture-MS Homo sapiens
189 PRKCA 5578
Affinity Capture-MS Homo sapiens
190 TUBA8 51807
Affinity Capture-MS Homo sapiens
191 LAMP1 3916
Affinity Capture-MS Homo sapiens
192 Smad3  
Affinity Capture-MS Mus musculus
193 CS 1431
Affinity Capture-MS Homo sapiens
194 CERK 64781
Affinity Capture-MS Homo sapiens
195 UBC 7316
Affinity Capture-MS Homo sapiens
196 RPS7 6201
Affinity Capture-MS Homo sapiens
197 Pkm 18746
Affinity Capture-MS Mus musculus
198 CTTN 2017
Co-fractionation Homo sapiens
199 RPL3 6122
Affinity Capture-MS Homo sapiens
200 RPN2 6185
Affinity Capture-MS Homo sapiens
201 RPS27A 6233
Affinity Capture-MS Homo sapiens
202 FUS 2521
Affinity Capture-MS Homo sapiens
203 RBM27  
Co-fractionation Homo sapiens
204 RPS17 6218
Affinity Capture-MS Homo sapiens
205 RAB35 11021
Affinity Capture-MS Homo sapiens
206 RIPK4  
Affinity Capture-MS Homo sapiens
207 PA2G4 5036
Affinity Capture-MS Homo sapiens
208 SPTBN1 6711
Affinity Capture-MS Homo sapiens
209 NXF1 10482
Affinity Capture-RNA Homo sapiens
210 FDFT1 2222
Affinity Capture-MS Homo sapiens
211 HSP90AB3P 3327
Affinity Capture-MS Homo sapiens
212 SGTB  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
213 SLC25A11 8402
Affinity Capture-MS Homo sapiens
214 GEMIN4 50628
Affinity Capture-MS Homo sapiens
215 MAPK6  
Affinity Capture-MS Homo sapiens
216 MOGS 7841
Affinity Capture-MS Homo sapiens
217 PCBP1 5093
Affinity Capture-MS Homo sapiens
218 TMED10 10972
Affinity Capture-MS Homo sapiens
219 TMED2 10959
Affinity Capture-MS Homo sapiens
220 RPL18A 6142
Affinity Capture-MS Homo sapiens
221 PCBP2 5094
Affinity Capture-MS Homo sapiens
222 Get4  
Affinity Capture-MS Mus musculus
223 RPS14 6208
Affinity Capture-MS Homo sapiens
224 IP6K3  
Affinity Capture-MS Homo sapiens
225 RPLP0 6175
Affinity Capture-MS Homo sapiens
226