Gene description for UBXN1
Gene name UBX domain protein 1
Gene symbol UBXN1
Other names/aliases 2B28
SAKS1
UBXD10
Species Homo sapiens
 Database cross references - UBXN1
ExoCarta ExoCarta_51035
Entrez Gene 51035
HGNC 18402
UniProt Q04323  
 UBXN1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for UBXN1
Molecular Function
    ATPase binding GO:0051117 IPI
    ubiquitin protein ligase binding GO:0031625 IDA
    K6-linked polyubiquitin binding GO:0071796 IDA
    ubiquitin binding GO:0043130 IDA
    protein binding GO:0005515 IPI
    polyubiquitin binding GO:0031593 IDA
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 NAS
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IDA
    negative regulation of protein ubiquitination GO:0031397 IDA
Subcellular Localization
    dendrite GO:0030425 IEA
    proteasome complex GO:0000502 IDA
    cytoplasm GO:0005737 IDA
    neuronal cell body GO:0043025 IEA
    nucleus GO:0005634 IEA
    VCP-NPL4-UFD1 AAA ATPase complex GO:0034098 IDA
 Experiment description of studies that identified UBXN1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBXN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK4 1019
Affinity Capture-MS Homo sapiens
2 ASF1B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which UBXN1 is involved
No pathways found





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