Gene description for PRPSAP2
Gene name phosphoribosyl pyrophosphate synthetase-associated protein 2
Gene symbol PRPSAP2
Other names/aliases PAP41
Species Homo sapiens
 Database cross references - PRPSAP2
ExoCarta ExoCarta_5636
Entrez Gene 5636
HGNC 9467
MIM 603762
UniProt O60256  
 PRPSAP2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for PRPSAP2
Molecular Function
    ribose phosphate diphosphokinase activity GO:0004749 IEA
    enzyme inhibitor activity GO:0004857 TAS
    magnesium ion binding GO:0000287 IEA
Biological Process
    nucleobase-containing compound metabolic process GO:0006139 TAS
    bone development GO:0060348 IEA
    negative regulation of catalytic activity GO:0043086 TAS
    nucleotide biosynthetic process GO:0009165 IEA
Subcellular Localization
    ribose phosphate diphosphokinase complex GO:0002189 IEA
 Experiment description of studies that identified PRPSAP2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRPSAP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRPSAP2 is involved
No pathways found





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