Gene description for CCNB1
Gene name cyclin B1
Gene symbol CCNB1
Other names/aliases CCNB
Species Homo sapiens
 Database cross references - CCNB1
ExoCarta ExoCarta_891
Vesiclepedia VP_891
Entrez Gene 891
HGNC 1579
MIM 123836
UniProt P14635  
 CCNB1 identified in sEVs derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CCNB1
Molecular Function
    patched binding GO:0005113 IPI
    protein binding GO:0005515 IPI
    cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IBA
    protein kinase binding GO:0019901 IPI
    ubiquitin-like protein ligase binding GO:0044389 IPI
    cyclin-dependent protein serine/threonine kinase activator activity GO:0061575 IDA
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IBA
    G2/M transition of mitotic cell cycle GO:0000086 NAS
    in utero embryonic development GO:0001701 IEA
    mitotic spindle organization GO:0007052 IMP
    mitotic metaphase chromosome alignment GO:0007080 IBA
    mitotic metaphase chromosome alignment GO:0007080 IMP
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IDA
    positive regulation of mitotic cell cycle GO:0045931 IMP
    positive regulation of fibroblast proliferation GO:0048146 IEA
    cell division GO:0051301 IEA
    positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 IMP
    regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266 IMP
    positive regulation of mitochondrial ATP synthesis coupled electron transport GO:1905448 IDA
Subcellular Localization
    spindle pole GO:0000922 IDA
    outer kinetochore GO:0000940 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 IDA
    centrosome GO:0005813 IDA
    microtubule organizing center GO:0005815 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 IEA
    cyclin B1-CDK1 complex GO:0097125 IBA
    cyclin B1-CDK1 complex GO:0097125 IDA
    cyclin B1-CDK1 complex GO:0097125 IPI
 Experiment description of studies that identified CCNB1 in sEVs
1
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CCNB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMA6 5687
Affinity Capture-Western Homo sapiens
2 RPA2 6118
Co-fractionation Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 CDC34 997
Biochemical Activity Homo sapiens
5 Hsp90ab1 15516
Two-hybrid Mus musculus
6 Cdk1 12534
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
7 NCBP1 4686
Affinity Capture-MS Homo sapiens
8 PPP1CB 5500
Affinity Capture-Western Homo sapiens
9 XIAP  
Reconstituted Complex Homo sapiens
10 CCNH  
Affinity Capture-MS Homo sapiens
11 ZCCHC6 79670
Affinity Capture-MS Homo sapiens
12 CDK3 1018
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
13 CCNB2  
Co-fractionation Homo sapiens
14 PTMA 5757
Co-purification Homo sapiens
15 RPS18 6222
Affinity Capture-MS Homo sapiens
16 GADD45G  
Reconstituted Complex Homo sapiens
17 GADD45A  
Reconstituted Complex Homo sapiens
18 SP1  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 Papss1  
Affinity Capture-MS Mus musculus
20 Pax3  
Two-hybrid Mus musculus
21 MFN1 55669
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 AP2A1 160
Co-fractionation Homo sapiens
23 BRCA1 672
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
24 RNASEH2C 84153
Co-fractionation Homo sapiens
25 C9orf78 51759
Affinity Capture-MS Homo sapiens
26 CDC25B 994
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
27 PRPSAP2 5636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CAND1 55832
Affinity Capture-MS Homo sapiens
29 CCNB1IP1  
Two-hybrid Homo sapiens
30 PKMYT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
31 PRKDC 5591
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 RPS3 6188
Affinity Capture-MS Homo sapiens
33 PPP1CC 5501
Affinity Capture-Western Homo sapiens
34 DIAPH3 81624
Co-fractionation Homo sapiens
35 PLEKHO1 51177
Negative Genetic Homo sapiens
36 CDC16 8881
Affinity Capture-Western Homo sapiens
37 PRDX3 10935
Affinity Capture-MS Homo sapiens
38 KIF22  
Affinity Capture-MS Homo sapiens
39 MAD2L1BP  
Affinity Capture-MS Homo sapiens
40 UBE2K 3093
Affinity Capture-Western Homo sapiens
41 NAV1 89796
Negative Genetic Homo sapiens
42 HERC5 51191
Reconstituted Complex Homo sapiens
43 Bms1  
Two-hybrid Mus musculus
44 FZR1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
45 PRC1 9055
Biochemical Activity Homo sapiens
46 CUX1 1523
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
47 PARVA 55742
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 MARCH5  
Affinity Capture-Western Homo sapiens
49 Snrnp70 20637
Two-hybrid Mus musculus
50 CCDC6 8030
Affinity Capture-Western Homo sapiens
51 OTUD7B 56957
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
52 SLC27A2 11001
Affinity Capture-MS Homo sapiens
53 GRWD1 83743
Affinity Capture-MS Homo sapiens
54 CDC27 996
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
55 CDT1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
56 ESPL1  
Affinity Capture-Western Homo sapiens
57 BTRC 8945
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
58 CCAR1 55749
Affinity Capture-MS Homo sapiens
59 USP37  
Affinity Capture-Western Homo sapiens
60 USP22 23326
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
61 RB1 5925
Biochemical Activity Homo sapiens
62 LRCH1 23143
Affinity Capture-MS Homo sapiens
63 GFAP 2670
Affinity Capture-MS Homo sapiens
64 PPP1CA 5499
Affinity Capture-Western Homo sapiens
65 VRK3 51231
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
66 RELA 5970
Affinity Capture-Western Homo sapiens
67 TREX1  
Affinity Capture-Western Homo sapiens
68 POLD1 5424
Co-fractionation Homo sapiens
69 CDH1 999
Biochemical Activity Homo sapiens
70 USP14 9097
Biochemical Activity Homo sapiens
71 PKN2 5586
Affinity Capture-MS Homo sapiens
72 CDKN1A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
73 PARK2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
74 CDK5 1020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CUL3 8452
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
76 DOCK7 85440
Affinity Capture-MS Homo sapiens
77 HIST1H1B 3009
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
78 MAD1L1  
Affinity Capture-MS Homo sapiens
79 STAU1 6780
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
80 WAC  
Affinity Capture-Western Homo sapiens
81 MKRN2 23609
Affinity Capture-RNA Homo sapiens
82 LRRFIP1 9208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 KLC3  
Affinity Capture-MS Homo sapiens
84 VCP 7415
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 OGT 8473
Reconstituted Complex Homo sapiens
86 ANAPC10  
Affinity Capture-Western Homo sapiens
87 CDKN1C  
Affinity Capture-MS Homo sapiens
88 PLK1 5347
Co-localization Homo sapiens
89 DCTN1 1639
Proximity Label-MS Homo sapiens
90 CHST15 51363
Affinity Capture-MS Homo sapiens
91 KPNB1 3837
Reconstituted Complex Homo sapiens
92 SPDYE4  
Affinity Capture-MS Homo sapiens
93 ANAPC4 29945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 MNAT1  
Affinity Capture-MS Homo sapiens
95 Prdx1 18477
Two-hybrid Mus musculus
96 CEBPA  
Protein-peptide Homo sapiens
97 ARID4A  
Biochemical Activity Homo sapiens
98 RMDN3 55177
Proximity Label-MS Homo sapiens
99 MGMT 4255
Affinity Capture-Western Homo sapiens
100 BCLAF1 9774
Affinity Capture-MS Homo sapiens
101 CDC14A  
Affinity Capture-Western Homo sapiens
102 UBE2N 7334
Biochemical Activity Homo sapiens
103 CCNA2 890
Co-localization Homo sapiens
Co-fractionation Homo sapiens
104 CDK7 1022
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 GADD45B  
Reconstituted Complex Homo sapiens
106 TOP1 7150
Co-fractionation Homo sapiens
107 XPO1 7514
Affinity Capture-MS Homo sapiens
108 CDC25A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
109 SIRT7  
Affinity Capture-MS Homo sapiens
110 TSPYL2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
111 Lmnb1  
Biochemical Activity Rattus norvegicus
112 FOXO1  
Co-localization Homo sapiens
113 Ncln 103425
Two-hybrid Mus musculus
114 Flna 192176
Two-hybrid Mus musculus
115 SKP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
116 UHRF2  
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
117 ZC3HC1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
118 NACC1 112939
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
119 CKS1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
120 TP73  
Reconstituted Complex Homo sapiens
121 WEE1 7465
Affinity Capture-MS Homo sapiens
122 Anapc16  
Affinity Capture-MS Mus musculus
123 Espl1  
Affinity Capture-MS Mus musculus
124 GRB10 2887
Negative Genetic Homo sapiens
125 CDK2 1017
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
126 UBE2D2 7322
Biochemical Activity Homo sapiens
127 RPA3 6119
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
128 STOM 2040
Affinity Capture-MS Homo sapiens
129 CCNF  
Affinity Capture-Western Homo sapiens
130 SET 6418
Affinity Capture-Western Homo sapiens
131 RBL2 5934
Affinity Capture-MS Homo sapiens
132 EPN1 29924
Co-fractionation Homo sapiens
133 PTPDC1  
Affinity Capture-MS Homo sapiens
134 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
135 NDC80 10403
Co-fractionation Homo sapiens
136 HIST1H1A 3024
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
137 KAT6A  
Affinity Capture-MS Homo sapiens
138 RHOB 388
Proximity Label-MS Homo sapiens
139 TRIM28 10155
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
140 CDKN1B 1027
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
141 Pcna 18538
Two-hybrid Mus musculus
142 IKZF5 64376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 Slc25a51  
Two-hybrid Mus musculus
144 Scube1  
Two-hybrid Mus musculus
145 SDHAF2 54949
Co-fractionation Homo sapiens
146 DZIP3  
Affinity Capture-MS Homo sapiens
147 RALBP1 10928
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
148 TARSL2 123283
Affinity Capture-MS Homo sapiens
149 LLGL2 3993
Affinity Capture-MS Homo sapiens
150 PSMC3IP  
Affinity Capture-MS Homo sapiens
151 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
152 CDC20 991
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
153 PARP1 142
Co-fractionation Homo sapiens
154 TGFBR2 7048
Reconstituted Complex Homo sapiens
155 RHOBTB3 22836
Affinity Capture-Western Homo sapiens
156 STK38 11329
Affinity Capture-MS Homo sapiens
157 FXR1 8087
Affinity Capture-MS Homo sapiens
158 RPA1 6117
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
159 KEAP1 9817
Affinity Capture-MS Homo sapiens
160 PDCD6 10016
Affinity Capture-MS Homo sapiens
161 SKP1 6500
Affinity Capture-MS Homo sapiens
162 RPTOR 57521
Affinity Capture-Western Homo sapiens
163 SQSTM1 8878
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
164 CDC6  
Biochemical Activity Homo sapiens
165 ANAPC1 64682
Affinity Capture-Western Homo sapiens
166 ZADH2 284273
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
167 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
168 CDC25C  
Reconstituted Complex Homo sapiens
169 OTUB1 55611
Affinity Capture-MS Homo sapiens
170 Ubtf 21429
Two-hybrid Mus musculus
171 SIRT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
172 CDK1 983
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
173 UBE3C 9690
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
174 PCNA 5111
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
175 MIF 4282
Affinity Capture-MS Homo sapiens
176 E2F3  
Affinity Capture-Western Homo sapiens
177 TRIM37  
Proximity Label-MS Homo sapiens
178 FAM110D  
Affinity Capture-MS Homo sapiens
179 GAPDH 2597
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
180 C1QC 714
Affinity Capture-MS Homo sapiens
181 HNRNPLL 92906
Co-fractionation Homo sapiens
182 FLNA 2316
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
183 Samhd1 56045
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
184 PRDX1 5052
Affinity Capture-MS Homo sapiens
185 AKR7A2 8574
Affinity Capture-MS Homo sapiens
186 FOXM1  
Affinity Capture-Western Homo sapiens
187 POLA1  
Co-fractionation Homo sapiens
188 XRCC6 2547
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
189 SNW1 22938
Affinity Capture-MS Homo sapiens
190 KRAS 3845
Negative Genetic Homo sapiens
191 UBE3D  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
192 CKS2  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
193 GAS2L1 10634
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
194 DNMT1 1786
Affinity Capture-MS Homo sapiens
195 NGB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 ALKBH8  
Affinity Capture-MS Homo sapiens
197 Rpl4 67891
Two-hybrid Mus musculus
198 EP300 2033
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
199 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CCNB1 is involved
PathwayEvidenceSource
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Activation of NIMA Kinases NEK9, NEK6, NEK7 TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Cyclin B TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cell Cycle, Mitotic IEA Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex TAS Reactome
Condensation of Prometaphase Chromosomes IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Cyclin A/B1/B2 associated events during G2/M transition TAS Reactome
Depolymerization of the Nuclear Lamina TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
E2F mediated regulation of DNA replication IEA Reactome
E2F-enabled inhibition of pre-replication complex formation IEA Reactome
G1/S Transition IEA Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
G2/M DNA replication checkpoint TAS Reactome
G2/M Transition TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Golgi Cisternae Pericentriolar Stack Reorganization IEA Reactome
Initiation of Nuclear Envelope (NE) Reformation TAS Reactome
M Phase TAS Reactome
M Phase IEA Reactome
MASTL Facilitates Mitotic Progression IEA Reactome
MITF-M-dependent gene expression TAS Reactome
MITF-M-regulated melanocyte development TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic G1 phase and G1/S transition IEA Reactome
Mitotic G2-G2/M phases TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Prometaphase TAS Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Prophase TAS Reactome
Mitotic Prophase IEA Reactome
Nuclear Envelope (NE) Reassembly TAS Reactome
Nuclear Envelope Breakdown TAS Reactome
Nuclear events stimulated by ALK signaling in cancer TAS Reactome
Nuclear Pore Complex (NPC) Disassembly TAS Reactome
Phosphorylation of Emi1 TAS Reactome
Phosphorylation of the APC/C TAS Reactome
Polo-like kinase mediated events TAS Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
Regulation of PLK1 Activity at G2/M Transition TAS Reactome
Resolution of Sister Chromatid Cohesion TAS Reactome
RNA Polymerase II Transcription TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
The role of GTSE1 in G2/M progression after G2 checkpoint TAS Reactome
TP53 Regulates Transcription of Cell Cycle Genes TAS Reactome
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TAS Reactome
Transcriptional regulation by RUNX2 TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome





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