Gene description for CHST15
Gene name carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
Gene symbol CHST15
Other names/aliases BRAG
GALNAC4S-6ST
Species Homo sapiens
 Database cross references - CHST15
ExoCarta ExoCarta_51363
Entrez Gene 51363
HGNC 18137
MIM 608277
UniProt Q7LFX5  
 CHST15 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CHST15
Molecular Function
    N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity GO:0050659 IDA
    3'-phosphoadenosine 5'-phosphosulfate binding GO:0050656 IDA
Biological Process
    glycosaminoglycan metabolic process GO:0030203 TAS
    chondroitin sulfate metabolic process GO:0030204 TAS
    carbohydrate metabolic process GO:0005975 TAS
    hexose biosynthetic process GO:0019319 IDA
    chondroitin sulfate biosynthetic process GO:0030206 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    integral component of membrane GO:0016021 NAS
    Golgi membrane GO:0000139 TAS
 Experiment description of studies that identified CHST15 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CHST15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HCK 3055
Invivo Homo sapiens
2 LYN 4067
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which CHST15 is involved
PathwayEvidenceSource
Chondroitin sulfate biosynthesis TAS Reactome





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