Gene description for ERC1
Gene name ELKS/RAB6-interacting/CAST family member 1
Gene symbol ERC1
Other names/aliases Cast2
ELKS
ERC-1
RAB6IP2
Species Homo sapiens
 Database cross references - ERC1
ExoCarta ExoCarta_23085
Vesiclepedia VP_23085
Entrez Gene 23085
HGNC 17072
MIM 607127
UniProt Q8IUD2  
 ERC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ERC1
Molecular Function
    protein binding GO:0005515 IPI
    PDZ domain binding GO:0030165 ISS
    small GTPase binding GO:0031267 ISS
    cadherin binding GO:0045296 HDA
    structural constituent of presynaptic active zone GO:0098882 IBA
Biological Process
    regulation of DNA-templated transcription GO:0006355 IDA
    I-kappaB phosphorylation GO:0007252 IDA
    protein transport GO:0015031 IEA
    retrograde transport, endosome to Golgi GO:0042147 ISS
    maintenance of presynaptic active zone structure GO:0048790 IBA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    podosome GO:0002102 ISS
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    centrosome GO:0005813 IDA
    IkappaB kinase complex GO:0008385 IDA
    ciliary basal body GO:0036064 IDA
    presynaptic membrane GO:0042734 TAS
    synapse GO:0045202 ISS
    anchoring junction GO:0070161 IEA
    presynaptic active zone cytoplasmic component GO:0098831 IBA
 Experiment description of studies that identified ERC1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ERC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT37 8688
Affinity Capture-MS Homo sapiens
2 NCBP1 4686
Co-fractionation Homo sapiens
3 XIAP  
Affinity Capture-Western Homo sapiens
4 MACROD1 28992
Affinity Capture-MS Homo sapiens
5 SMURF1 57154
Affinity Capture-MS Homo sapiens
6 RACGAP1 29127
Affinity Capture-MS Homo sapiens
7 YWHAE 7531
Affinity Capture-MS Homo sapiens
8 SPERT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 NUP62 23636
Affinity Capture-MS Homo sapiens
10 NHLRC2 374354
Affinity Capture-MS Homo sapiens
11 MFAP4 4239
Affinity Capture-MS Homo sapiens
12 TRIM33 51592
Affinity Capture-MS Homo sapiens
13 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
14 Actb 11461
Affinity Capture-MS Mus musculus
15 APP 351
Reconstituted Complex Homo sapiens
16 TMEM200A 114801
Cross-Linking-MS (XL-MS) Homo sapiens
17 SLC16A6 9120
Affinity Capture-MS Homo sapiens
18 APEX1 328
Affinity Capture-RNA Homo sapiens
19 VPS26A 9559
Co-fractionation Homo sapiens
20 CAPZB 832
Affinity Capture-MS Homo sapiens
21 DYRK1A 1859
Affinity Capture-MS Homo sapiens
22 KIF23 9493
Affinity Capture-MS Homo sapiens
23 PCGF1 84759
Affinity Capture-MS Homo sapiens
24 ACTR3 10096
Proximity Label-MS Homo sapiens
25 CEP112  
Affinity Capture-MS Homo sapiens
26 IMPDH2 3615
Proximity Label-MS Homo sapiens
27 POU5F1  
Affinity Capture-MS Homo sapiens
28 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ATRX 546
Affinity Capture-MS Homo sapiens
30 YWHAH 7533
Affinity Capture-MS Homo sapiens
31 ATG16L1 55054
Affinity Capture-MS Homo sapiens
32 CYP2C9  
Proximity Label-MS Homo sapiens
33 SERF2 10169
Affinity Capture-MS Homo sapiens
34 RAB6B 51560
Reconstituted Complex Homo sapiens
35 TSHB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MAPK4  
Affinity Capture-MS Homo sapiens
37 AMOT  
Proximity Label-MS Homo sapiens
38 DVL2 1856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 KIF14 9928
Affinity Capture-MS Homo sapiens
40 EEA1 8411
Cross-Linking-MS (XL-MS) Homo sapiens
41 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 C15orf59  
Affinity Capture-MS Homo sapiens
43 PFN1 5216
Proximity Label-MS Homo sapiens
44 KRT8 3856
Proximity Label-MS Homo sapiens
45 RPL4 6124
Cross-Linking-MS (XL-MS) Homo sapiens
46 DYNC1I2 1781
Proximity Label-MS Homo sapiens
47 MAPRE1 22919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 OFD1 8481
Affinity Capture-MS Homo sapiens
49 TBC1D32 221322
Proximity Label-MS Homo sapiens
50 CDH1 999
Proximity Label-MS Homo sapiens
51 PPP1R21 129285
Affinity Capture-MS Homo sapiens
52 PEX14 5195
Proximity Label-MS Homo sapiens
53 BICD2 23299
Proximity Label-MS Homo sapiens
54 YWHAQ 10971
Affinity Capture-MS Homo sapiens
55 KRT38 8687
Affinity Capture-MS Homo sapiens
56 AGPS 8540
Proximity Label-MS Homo sapiens
57 LATS2 26524
Proximity Label-MS Homo sapiens
58 PIPSL 266971
Affinity Capture-MS Homo sapiens
59 ANLN 54443
Affinity Capture-MS Homo sapiens
60 RAB6A 5870
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
61 ATP6V0D1 9114
Co-fractionation Homo sapiens
62 Myh9 17886
Affinity Capture-MS Mus musculus
63 Cd2ap 12488
Affinity Capture-MS Mus musculus
64 CEP135  
Affinity Capture-MS Homo sapiens
65 NFKBIA  
Affinity Capture-Western Homo sapiens
66 ERC2 26059
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
67 CDK19 23097
Affinity Capture-MS Homo sapiens
68 CUL3 8452
Affinity Capture-MS Homo sapiens
69 DES 1674
Affinity Capture-MS Homo sapiens
70 KBTBD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CHST15 51363
Affinity Capture-MS Homo sapiens
72 MYO6 4646
Proximity Label-MS Homo sapiens
73 NEFM 4741
Proximity Label-MS Homo sapiens
74 NIN 51199
Proximity Label-MS Homo sapiens
75 DLST 1743
Co-fractionation Homo sapiens
76 GOLGA1  
Proximity Label-MS Homo sapiens
77 NDC80 10403
Proximity Label-MS Homo sapiens
78 CDK20  
Affinity Capture-MS Homo sapiens
79 BICD1 636
Proximity Label-MS Homo sapiens
80 PCM1 5108
Proximity Label-MS Homo sapiens
81 STK4 6789
Affinity Capture-MS Homo sapiens
82 MAP3K7  
Affinity Capture-Western Homo sapiens
83 NANOG  
Affinity Capture-MS Homo sapiens
84 KRT19 3880
Proximity Label-MS Homo sapiens
85 CHUK 1147
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
86 TWF2 11344
Affinity Capture-MS Homo sapiens
87 FTL 2512
Affinity Capture-MS Homo sapiens
88 KRT18 3875
Proximity Label-MS Homo sapiens
89 RAD23A 5886
Affinity Capture-MS Homo sapiens
90 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
91 WDR4 10785
Co-fractionation Homo sapiens
92 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
93 Ckap5 75786
Affinity Capture-MS Mus musculus
94 SEPT10 151011
Proximity Label-MS Homo sapiens
95 MKRN3  
Affinity Capture-MS Homo sapiens
96 DCTN2 10540
Proximity Label-MS Homo sapiens
97 ADPRHL2 54936
Co-fractionation Homo sapiens
98 ANAPC2 29882
Proximity Label-MS Homo sapiens
99 ERGIC2 51290
Proximity Label-MS Homo sapiens
100 ITSN2 50618
Two-hybrid Homo sapiens
101 KDM1A 23028
Proximity Label-MS Homo sapiens
102 ING1  
Affinity Capture-MS Homo sapiens
103 EYA4 2070
Affinity Capture-MS Homo sapiens
104 Kif4  
Affinity Capture-MS Mus musculus
105 PXN 5829
Proximity Label-MS Homo sapiens
106 CEBPB  
Co-fractionation Homo sapiens
107 SNX2 6643
Co-fractionation Homo sapiens
108 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
109 MYC  
Affinity Capture-MS Homo sapiens
110 IKBKB 3551
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
111 GFOD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ERC1 is involved
No pathways found





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