ExoCarta: Gene summary

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Gene description for CDK19
Gene name	cyclin-dependent kinase 19
Gene symbol	CDK19
Other names/aliases	CDC2L6 CDK11 bA346C16.3
Species	Homo sapiens
Database cross references - CDK19
ExoCarta	ExoCarta_23097
Vesiclepedia	VP_23097
Entrez Gene	23097
HGNC	19338
MIM	614720
UniProt	Q9BWU1
CDK19 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	36408942

Gene ontology annotations for CDK19

Molecular Function
	protein serine/threonine kinase activity	GO:0004674	IBA
	cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA
	ATP binding	GO:0005524	IEA
	protein serine kinase activity	GO:0106310	IEA
Biological Process
	positive regulation of apoptotic process	GO:0043065	IEA
	regulation of cell cycle	GO:0051726	IEA
	cellular response to lipopolysaccharide	GO:0071222	IEA
Subcellular Localization
	nucleus	GO:0005634	IBA
	nucleoplasm	GO:0005654	IDA
	nucleoplasm	GO:0005654	TAS
	cytosol	GO:0005829	IBA
	cytosol	GO:0005829	IDA
	perinuclear region of cytoplasm	GO:0048471	IEA
	CKM complex	GO:1990508	ISS

Experiment description of studies that identified CDK19 in sEVs

Experiment ID

488

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD81\|CD63\|GAPDH\|SDCBP\|LAMP1\|TFRC\|UCHL1\|FLOT2\|LAMP2\|FLOT1\|ICAM1\|RAB5B\|CD151\|RAB35\|TSG101\|RAB5A\|CD82	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Homo sapiens

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Mesenchymal stem cells

Sample name

UCMSC

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for CDK19

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

MED11

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

POLR2B

5431

Affinity Capture-MS

Homo sapiens

POLR2C

5432

Affinity Capture-MS

Homo sapiens

MYCBPAP

84073

Affinity Capture-MS

Homo sapiens

GPN1

Co-fractionation

Homo sapiens

MED27

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED19

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

POLR2G

5436

Affinity Capture-MS

Homo sapiens

LZIC

84328

Affinity Capture-MS

Homo sapiens

MED15

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED17

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

WDR77

79084

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

CUTA

51596

Co-fractionation

Homo sapiens

CTCF

Co-fractionation

Homo sapiens

CCNC

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CDK8

1024

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED4

29079

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PIP

5304

Affinity Capture-MS

Homo sapiens

FKBP15

23307

Co-fractionation

Homo sapiens

MED1

5469

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPAP2

Affinity Capture-MS

Homo sapiens

MED29

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

POLR2E

5434

Affinity Capture-MS

Homo sapiens

MRPS31

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ACAD11

84129

Affinity Capture-MS

Homo sapiens

FBXL19

Affinity Capture-MS

Homo sapiens

MED9

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED13L

23389

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED8

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED7

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GNAQ

2776

Co-fractionation

Homo sapiens

MED6

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RB1CC1

9821

Affinity Capture-MS

Homo sapiens

MED24

9862

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CLU

1191

Affinity Capture-MS

Homo sapiens

MASP1

5648

Affinity Capture-MS

Homo sapiens

STK38

11329

Affinity Capture-Western

Homo sapiens

AZGP1

563

Affinity Capture-MS

Homo sapiens

POLR2A

5430

Affinity Capture-MS

Homo sapiens

SUZ12

Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens

POLR2H

5437

Affinity Capture-MS

Homo sapiens

APOD

347

Affinity Capture-MS

Homo sapiens

MED12L

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RNPC3

Co-fractionation

Homo sapiens

MED30

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED16

10025

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PRMT5

10419

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

MED18

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED21

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED10

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SMARCA4

6597

Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens

MED12

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PBXIP1

57326

Affinity Capture-MS

Homo sapiens

SRSF7

6432

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

MED26

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

POLR2I

5438

Affinity Capture-MS

Homo sapiens

MED20

9477

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MYEF2

50804

Co-fractionation

Homo sapiens

MED23

9439

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ERC1

23085

Affinity Capture-MS

Homo sapiens

BCL6

Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens

MED25

Affinity Capture-MS

Homo sapiens

ZC3H13

23091

Affinity Capture-MS

Homo sapiens

IGFBP6

3489

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BIRC8

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED31

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FAM49B

51571

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DNAJC12

Affinity Capture-MS

Homo sapiens

COMMD4

54939

Co-fractionation

Homo sapiens

MED13

9969

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED14

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MED22

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NIFK

84365

Co-fractionation

Homo sapiens

MED28

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

View the network

Pathways in which CDK19 is involved

Pathway	Evidence	Source
Adipogenesis	TAS	Reactome
Adipogenesis	IEA	Reactome
Developmental Biology	TAS	Reactome
Developmental Biology	IEA	Reactome
Disease	TAS	Reactome
Infectious disease	TAS	Reactome
Metabolism	TAS	Reactome
Metabolism of lipids	TAS	Reactome
PPARA activates gene expression	TAS	Reactome
Regulation of lipid metabolism by PPARalpha	TAS	Reactome
Respiratory Syncytial Virus Infection Pathway	TAS	Reactome
RSV-host interactions	TAS	Reactome
Transcriptional regulation of white adipocyte differentiation	TAS	Reactome
Transcriptional regulation of white adipocyte differentiation	IEA	Reactome
Viral Infection Pathways	TAS	Reactome

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