Gene description for IGFBP6
Gene name insulin-like growth factor binding protein 6
Gene symbol IGFBP6
Other names/aliases IBP6
Species Homo sapiens
 Database cross references - IGFBP6
ExoCarta ExoCarta_3489
Entrez Gene 3489
HGNC 5475
MIM 146735
UniProt P24592  
 IGFBP6 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IGFBP6
Molecular Function
    insulin-like growth factor II binding GO:0031995 IBA
    insulin-like growth factor I binding GO:0031994 IBA
Biological Process
    regulation of cell growth GO:0001558 IEA
    cellular protein metabolic process GO:0044267 TAS
    negative regulation of cell proliferation GO:0008285 TAS
    signal transduction GO:0007165 NAS
    regulation of insulin-like growth factor receptor signaling pathway GO:0043567 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    Golgi apparatus GO:0005794 IEA
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified IGFBP6 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IGFBP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGF2 3481
Reconstituted Complex Homo sapiens
2 TF 7018
Invitro Homo sapiens
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