Gene description for IGF2
Gene name	insulin-like growth factor 2
Gene symbol	IGF2
Other names/aliases	C11orf43 IGF-II PP9974
Species	Homo sapiens
Database cross references - IGF2
ExoCarta	ExoCarta_3481
Entrez Gene	3481
HGNC	5466
MIM	147470
UniProt	P01344
IGF2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Prostate cancer cells	25844599

Gene ontology annotations for IGF2

Molecular Function     protein serine/threonine kinase activator activity GO:0043539 ISS     protein binding GO:0005515 IPI     receptor activator activity GO:0030546 ISS     hormone activity GO:0005179 IEA     insulin-like growth factor receptor binding GO:0005159 IEA     growth factor activity GO:0008083 IDA     insulin receptor binding GO:0005158 IPI Biological Process     exocrine pancreas development GO:0031017 IEA     glucose metabolic process GO:0006006 IEA     female pregnancy GO:0007565 IEA     platelet activation GO:0030168 TAS     regulation of transcription, DNA-templated GO:0006355 NAS     positive regulation of protein phosphorylation GO:0001934 ISS     regulation of gene expression by genetic imprinting GO:0006349 TAS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS     positive regulation of MAPK cascade GO:0043410 IDA     platelet degranulation GO:0002576 TAS     response to drug GO:0042493 IEA     positive regulation of steroid hormone biosynthetic process GO:0090031 IEA     positive regulation of cell proliferation GO:0008284 IC     cellular response to mechanical stimulus GO:0071260 IEA     positive regulation of catalytic activity GO:0043085 ISS     response to nutrient levels GO:0031667 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     positive regulation of protein kinase B signaling GO:0051897 IDA     positive regulation of mitotic nuclear division GO:0045840 IDA     blood coagulation GO:0007596 TAS     insulin receptor signaling pathway GO:0008286 TAS     response to nicotine GO:0035094 IEA     positive regulation of receptor activity GO:2000273 IEA     response to radiation GO:0009314 IEA     skeletal system development GO:0001501 TAS     striated muscle cell differentiation GO:0051146 IEA     positive regulation of activated T cell proliferation GO:0042104 IDA     positive regulation of glycogen biosynthetic process GO:0045725 ISS     positive regulation of glycogen (starch) synthase activity GO:2000467 ISS     multicellular organismal development GO:0007275 TAS     osteoblast differentiation GO:0001649 IEA     memory GO:0007613 IEA     positive regulation of insulin receptor signaling pathway GO:0046628 IDA     positive regulation of protein serine/threonine kinase activity GO:0071902 IEA     insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028 ISS     organ morphogenesis GO:0009887 IEA     response to ethanol GO:0045471 IEA     response to estradiol GO:0032355 IEA     cellular protein metabolic process GO:0044267 TAS Subcellular Localization     extracellular region GO:0005576 TAS     extracellular exosome GO:0070062 IDA     plasma membrane GO:0005886 TAS     platelet alpha granule lumen GO:0031093 TAS     extracellular space GO:0005615 IEA