Gene description for IGFBP3
Gene name	insulin-like growth factor binding protein 3
Gene symbol	IGFBP3
Other names/aliases	BP-53 IBP3
Species	Homo sapiens
Database cross references - IGFBP3
ExoCarta	ExoCarta_3486
Entrez Gene	3486
HGNC	5472
MIM	146732
UniProt	P17936
IGFBP3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for IGFBP3

Molecular Function     protein binding GO:0005515 IPI     insulin-like growth factor I binding GO:0031994 IPI     insulin-like growth factor II binding GO:0031995 IBA     protein tyrosine phosphatase activator activity GO:0008160 IDA     metal ion binding GO:0046872 NAS     fibronectin binding GO:0001968 IBA     insulin-like growth factor binding GO:0005520 NAS Biological Process     positive regulation of MAPK cascade GO:0043410 IEA     negative regulation of signal transduction GO:0009968 NAS     cellular protein metabolic process GO:0044267 TAS     type B pancreatic cell proliferation GO:0044342 IEA     regulation of insulin-like growth factor receptor signaling pathway GO:0043567 IBA     positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 IEA     positive regulation of apoptotic process GO:0043065 IMP     apoptotic process GO:0006915 IEA     positive regulation of myoblast differentiation GO:0045663 IDA     negative regulation of smooth muscle cell migration GO:0014912 IDA     osteoblast differentiation GO:0001649 IEA     negative regulation of smooth muscle cell proliferation GO:0048662 IDA     negative regulation of protein phosphorylation GO:0001933 IDA     positive regulation of catalytic activity GO:0043085 IDA     regulation of glucose metabolic process GO:0010906 IEA     negative regulation of cell proliferation GO:0008285 IGI     regulation of cell growth GO:0001558 IEA     protein phosphorylation GO:0006468 IDA Subcellular Localization     extracellular space GO:0005615 IDA     extracellular exosome GO:0070062 IDA     insulin-like growth factor binding protein complex GO:0016942 IC     extracellular region GO:0005576 TAS     nucleus GO:0005634 IDA