Gene description for Ltbp1
Gene name latent transforming growth factor beta binding protein 1
Gene symbol Ltbp1
Other names/aliases 9430031G15Rik
9830146M04
Ltbp-1
Tgfb
b2b1000Clo
Species Mus musculus
 Database cross references - Ltbp1
ExoCarta ExoCarta_268977
Entrez Gene 268977
UniProt Q8CG19  
 Ltbp1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ltbp1
Molecular Function
    growth factor binding GO:0019838 IEA
    transforming growth factor beta binding GO:0050431 ISO
    microfibril binding GO:0050436 ISO
    calcium ion binding GO:0005509 IEA
Biological Process
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IDA
    extracellular region GO:0005576 IEA
    microfibril GO:0001527 ISO
    protein complex GO:0043234 ISO
    extracellular matrix GO:0031012 ISO
 Experiment description of studies that identified Ltbp1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ltbp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGFBP3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Ltbp1 is involved
PathwayEvidenceSource
Molecules associated with elastic fibres IEA Reactome





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