Gene description for RXRA
Gene name retinoid X receptor, alpha
Gene symbol RXRA
Other names/aliases NR2B1
Species Homo sapiens
 Database cross references - RXRA
ExoCarta ExoCarta_6256
Vesiclepedia VP_6256
Entrez Gene 6256
HGNC 10477
MIM 180245
UniProt P19793  
 RXRA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RXRA
Molecular Function
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IDA
    retinoic acid-responsive element binding GO:0044323 IDA
    retinoic acid receptor activity GO:0003708 TAS
    transcription regulatory region DNA binding GO:0044212 IDA
    chromatin DNA binding GO:0031490 IEA
    steroid hormone receptor activity GO:0003707 IEA
    protein binding GO:0005515 IPI
    transcription coactivator activity GO:0003713 TAS
    zinc ion binding GO:0008270 IEA
    DNA binding GO:0003677 IDA
    enzyme binding GO:0019899 IPI
    vitamin D response element binding GO:0070644 IDA
    sequence-specific DNA binding GO:0043565 IDA
    9-cis retinoic acid receptor activity GO:0004886 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 IDA
    protein heterodimerization activity GO:0046982 IDA
    vitamin D receptor binding GO:0042809 IPI
Biological Process
    maternal placenta development GO:0001893 IEA
    regulation of branching involved in prostate gland morphogenesis GO:0060687 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    embryo implantation GO:0007566 IEA
    gene expression GO:0010467 TAS
    positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 IEA
    small molecule metabolic process GO:0044281 TAS
    response to retinoic acid GO:0032526 IMP
    cellular lipid metabolic process GO:0044255 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    protein homotetramerization GO:0051289 IDA
    vitamin metabolic process GO:0006766 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    bile acid and bile salt transport GO:0015721 TAS
    retinoic acid receptor signaling pathway GO:0048384 IMP
    camera-type eye development GO:0043010 IEA
    secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 IEA
    peroxisome proliferator activated receptor signaling pathway GO:0035357 IDA
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IEA
    ventricular cardiac muscle cell differentiation GO:0055012 IEA
    in utero embryonic development GO:0001701 IEA
    steroid hormone mediated signaling pathway GO:0043401 IEA
    bile acid metabolic process GO:0008206 TAS
    positive regulation of translational initiation by iron GO:0045994 IEA
    modulation by virus of host morphology or physiology GO:0019048 IDA
    cholesterol metabolic process GO:0008203 TAS
Subcellular Localization
    nuclear chromatin GO:0000790 IDA
    RNA polymerase II transcription factor complex GO:0090575 IDA
    receptor complex GO:0043235 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified RXRA in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RXRA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LAMTOR5 10542
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 ZBTB16  
Affinity Capture-MS Homo sapiens
3 RELA 5970
Reconstituted Complex Homo sapiens
4 RNF8  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
5 NCOA6  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 HDAC4  
Reconstituted Complex Homo sapiens
7 VDR  
Invitro Homo sapiens
8 RARA 5914
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
9 Gadd45b  
Reconstituted Complex Mus musculus
10 CTSL 1514
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
11 NR4A1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
12 TRIP10 9322
Affinity Capture-MS Homo sapiens
13 NR4A2  
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
14 COPS2 9318
Affinity Capture-MS Homo sapiens
15 THRB 7068
Reconstituted Complex Homo sapiens
16 NCOA1  
Two-hybrid Homo sapiens
17 MED1 5469
Invivo Homo sapiens
Invitro Homo sapiens
18 GADD45G  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
19 TIF1  
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
20 GADD45A  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
21 SP1  
Invivo Homo sapiens
Invitro Homo sapiens
22 TMPRSS3  
Two-hybrid Homo sapiens
23 Pparg 19016
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
24 BRD8 10902
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
25 NCOA2 10499
Two-hybrid Homo sapiens
26 IGFBP3  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
27 BCL3  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
28 FUS 2521
Invitro Homo sapiens
Invivo Homo sapiens
29 PNRC2  
Affinity Capture-MS Homo sapiens
30 NPAS2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
31 NR0B2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
32 POU2F1 5451
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
33 MYOD1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
34 THRA  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
35 TBP  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
36 ITGB3BP  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
37 NFKB1 4790
Reconstituted Complex Homo sapiens
38 NR1I2  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
39 PPARG 5468
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
40 HDAC3 8841
Reconstituted Complex Homo sapiens
41 MED24 9862
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
42 PPARA  
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
43 TRIP4 9325
Affinity Capture-MS Homo sapiens
44 RXRA 6256
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 NRBF2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
46 CTNNB1 1499
Affinity Capture-Western Homo sapiens
47 PARP1 142
Invitro Homo sapiens
48 UBQLN4 56893
Two-hybrid Homo sapiens
49 NR1H4  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
50 NRIP1 8204
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
51 TAF11  
Invitro Homo sapiens
52 SRC 6714
Reconstituted Complex Homo sapiens
53 PML 5371
Reconstituted Complex Homo sapiens
54 NFKBIB  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
55 TDG 6996
Reconstituted Complex Homo sapiens
56 NCOA3  
Reconstituted Complex Homo sapiens
57 EDF1 8721
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
58 PPARGC1A  
Invivo Homo sapiens
Invitro Homo sapiens
59 NR1H2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
60 TADA3L  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
61 NR1I3  
Invitro Homo sapiens
62 NCOA4 8031
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
63 ERBP  
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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