Gene description for PIK3R1
Gene name phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene symbol PIK3R1
Other names/aliases AGM7
GRB1
IMD36
p85
p85-ALPHA
Species Homo sapiens
 Database cross references - PIK3R1
ExoCarta ExoCarta_5295
Vesiclepedia VP_5295
Entrez Gene 5295
HGNC 8979
MIM 171833
UniProt P27986  
 PIK3R1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for PIK3R1
Molecular Function
    ErbB-3 class receptor binding GO:0043125 IDA
    insulin-like growth factor receptor binding GO:0005159 IPI
    protein binding GO:0005515 IPI
    insulin receptor binding GO:0005158 IPI
    transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 ISS
    phosphatidylinositol 3-kinase regulator activity GO:0035014 ISS
    transcription factor binding GO:0008134 IPI
    protein phosphatase binding GO:0019903 IPI
    neurotrophin TRKA receptor binding GO:0005168 IPI
    insulin receptor substrate binding GO:0043560 ISS
    1-phosphatidylinositol-3-kinase regulator activity GO:0046935 IBA
    phosphatidylinositol 3-kinase binding GO:0043548 ISS
    insulin binding GO:0043559 IDA
Biological Process
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    negative regulation of osteoclast differentiation GO:0045671 IEA
    protein phosphorylation GO:0006468 IEA
    cellular glucose homeostasis GO:0001678 ISS
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    positive regulation of glucose import GO:0046326 ISS
    positive regulation of cell migration GO:0030335 IEA
    insulin receptor signaling pathway GO:0008286 TAS
    regulation of phosphatidylinositol 3-kinase activity GO:0043551 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    viral process GO:0016032 IEA
    insulin-like growth factor receptor signaling pathway GO:0048009 IPI
    negative regulation of cell-matrix adhesion GO:0001953 IEA
    T cell costimulation GO:0031295 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    blood coagulation GO:0007596 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    positive regulation of RNA splicing GO:0033120 IMP
    B cell differentiation GO:0030183 IEA
    response to endoplasmic reticulum stress GO:0034976 ISS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    cellular response to insulin stimulus GO:0032869 ISS
    cellular response to UV GO:0034644 IEA
    positive regulation of establishment of protein localization to plasma membrane GO:0090004 ISS
    phosphatidylinositol 3-kinase signaling GO:0014065 IDA
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IEA
    growth hormone receptor signaling pathway GO:0060396 IDA
    phosphatidylinositol phosphorylation GO:0046854 ISS
    positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 IMP
    protein stabilization GO:0050821 IDA
    platelet activation GO:0030168 TAS
    leukocyte migration GO:0050900 TAS
    NFAT protein import into nucleus GO:0051531 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA
    small molecule metabolic process GO:0044281 TAS
    negative regulation of apoptotic process GO:0043066 IMP
    positive regulation of transcription factor import into nucleus GO:0042993 ISS
    phospholipid metabolic process GO:0006644 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    T cell receptor signaling pathway GO:0050852 TAS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    innate immune response GO:0045087 TAS
Subcellular Localization
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 ISS
    plasma membrane GO:0005886 TAS
    nucleus GO:0005634 ISS
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 IDA
    cell-cell junction GO:0005911 IEA
    cytosol GO:0005829 TAS
    phosphatidylinositol 3-kinase complex GO:0005942 ISS
 Experiment description of studies that identified PIK3R1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 207
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70|FLOT1
EV Enriched markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 208
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70|FLOT1
EV Enriched markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 209
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70|FLOT1
EV Enriched markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 1203
MISEV standards
✔
EM
EV Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
13
Experiment ID 211
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 212
MISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PIK3R1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AXL 558
Biochemical Activity Homo sapiens
2 ARHGAP1 392
Invitro Homo sapiens
3 SHC1 6464
Reconstituted Complex Homo sapiens
4 PXN  
Co-purification Homo sapiens
5 MME 4311
Invitro Homo sapiens
6 CD2AP 23607
Invitro Homo sapiens
7 HRAS 3265
Invivo Homo sapiens
8 GNAQ 2776
Affinity Capture-Western Homo sapiens
9 SHB 6461
Invitro Homo sapiens
10 PIK3AP1  
Invitro Homo sapiens
Invivo Homo sapiens
11 PIK3CD 5293
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 TYRO3 7301
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
13 WAS 7454
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 PDGFRB 5159
Invivo Homo sapiens
15 TLN1 7094
Co-purification Homo sapiens
16 FES 2242
Invitro Homo sapiens
17 MST1R 4486
Invivo Homo sapiens
18 HGS 9146
Invitro Homo sapiens
19 SRC 6714
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
20 KHDRBS1 10657
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 CD3E 916
Affinity Capture-Western Homo sapiens
22 GAB2 9846
Invivo Homo sapiens
Invitro Homo sapiens
23 TOM1L1 10040
Invitro Homo sapiens
24 EPOR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
25 CD28  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
26 CBLB 868
Affinity Capture-Western Homo sapiens
27 Ctnnb1 12387
Affinity Capture-Western Mus musculus
28 ADAM12 8038
Invivo Homo sapiens
Invitro Homo sapiens
29 PFN1 5216
Invivo Homo sapiens
30 INPP4A 3631
Invivo Homo sapiens
31 BCAR1 9564
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 KIT 3815
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
33 FASLG 356
Invivo Homo sapiens
34 VAV1 7409
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
35 IL1RAP 3556
Invivo Homo sapiens
Invitro Homo sapiens
36 CD7  
Invivo Homo sapiens
Invitro Homo sapiens
37 IGF1R 3480
Invitro Homo sapiens
38 ERBB3 2065
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
39 CSF2RA  
Invivo Homo sapiens
40 RRAS2 22800
Affinity Capture-Western Homo sapiens
41 TUBA1B 10376
Invivo Homo sapiens
42 FYN 2534
Reconstituted Complex Homo sapiens
43 PIK3CB 5291
Invivo Homo sapiens
Invitro Homo sapiens
44 CRKL 1399
Invivo Homo sapiens
45 PIK3R1 5295
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
46 TGFBR1 7046
Invivo Homo sapiens
47 PECAM1 5175
Invitro Homo sapiens
48 ARHGAP17 55114
Reconstituted Complex Homo sapiens
49 LAT 27040
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
50 PTPN11 5781
Invivo Homo sapiens
51 PTPN6 5777
Two-hybrid Homo sapiens
52 CTNNB1 1499
Reconstituted Complex Homo sapiens
53 NFKBIA  
Invivo Homo sapiens
Invitro Homo sapiens
54 PTK2 5747
Invivo Homo sapiens
55 GAB1  
Reconstituted Complex Homo sapiens
56 CDC42 998
Invitro Homo sapiens
Invivo Homo sapiens
57 CD5 921
Invivo Homo sapiens
58 IFNAR1  
Affinity Capture-Western Homo sapiens
59 JAK1 3716
Invivo Homo sapiens
60 CENTG1  
Invivo Homo sapiens
61 PIK3CA 5290
Reconstituted Complex Homo sapiens
62 IL2RB  
Invivo Homo sapiens
Invitro Homo sapiens
63 ARAF 369
Reconstituted Complex Homo sapiens
64 CSF1R  
Affinity Capture-Western Homo sapiens
65 GRB2 2885
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
66 CD19 930
Invivo Homo sapiens
67 RICS  
Affinity Capture-Western Homo sapiens
68 TUBG1 7283
Invivo Homo sapiens
69 IL1R1 3554
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 EZR 7430
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
71 IRS2 8660
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
72 LCK 3932
Reconstituted Complex Homo sapiens
73 ABL1 25
Reconstituted Complex Homo sapiens
74 FCGR2A 2212
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
75 Thra  
Affinity Capture-Western Rattus norvegicus
76 ESR1  
Invivo Homo sapiens
77 DOK1 1796
Reconstituted Complex Homo sapiens
78 LCP2 3937
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
79 EPHA2 1969
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
80 GHR  
Invivo Homo sapiens
81 SH3KBP1 30011
Invivo Homo sapiens
82 SYN1  
Invivo Homo sapiens
83 RAC1 5879
Invitro Homo sapiens
84 NUP85 79902
Invivo Homo sapiens
85 IRS4 8471
Invivo Homo sapiens
86 JAK2 3717
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
87 IRS1 3667
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PIK3R1 is involved
PathwayEvidenceSource
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
CD28 dependent PI3K/Akt signaling TAS Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Constitutive Signaling by EGFRvIII TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
Costimulation by the CD28 family TAS Reactome
DAP12 signaling TAS Reactome
Downstream signal transduction TAS Reactome
Downstream TCR signaling TAS Reactome
G alpha (12/13) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
G beta:gamma signalling through PI3Kgamma TAS Reactome
GAB1 signalosome TAS Reactome
GP1b-IX-V activation signalling TAS Reactome
GPVI-mediated activation cascade TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-3, 5 and GM-CSF signaling TAS Reactome
Interleukin-7 signaling TAS Reactome
Nephrin interactions TAS Reactome
PI-3K cascade:FGFR1 TAS Reactome
PI-3K cascade:FGFR2 TAS Reactome
PI-3K cascade:FGFR3 TAS Reactome
PI-3K cascade:FGFR4 TAS Reactome
PI3K Cascade TAS Reactome
PI3K Cascade TAS Reactome
PI3K events in ERBB2 signaling TAS Reactome
PI3K events in ERBB4 signaling TAS Reactome
PI3K/AKT activation TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Regulation of signaling by CBL TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
Role of phospholipids in phagocytosis TAS Reactome
Signaling by FGFR1 fusion mutants TAS Reactome
Signaling by FGFR1 mutants TAS Reactome
Signaling by FGFR2 mutants TAS Reactome
Signaling by FGFR3 mutants TAS Reactome
Signaling by FGFR4 mutants TAS Reactome
Signaling by SCF-KIT TAS Reactome
Synthesis of PIPs at the plasma membrane TAS Reactome
Tie2 Signaling TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here