Gene description for PIK3R1
Gene name	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene symbol	PIK3R1
Other names/aliases	AGM7 GRB1 IMD36 p85 p85-ALPHA
Species	Homo sapiens
Database cross references - PIK3R1
ExoCarta	ExoCarta_5295
Entrez Gene	5295
HGNC	8979
MIM	171833
UniProt	P27986
PIK3R1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for PIK3R1

Molecular Function     ErbB-3 class receptor binding GO:0043125 IDA     insulin-like growth factor receptor binding GO:0005159 IPI     protein binding GO:0005515 IPI     insulin receptor binding GO:0005158 IPI     transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 ISS     phosphatidylinositol 3-kinase regulator activity GO:0035014 ISS     transcription factor binding GO:0008134 IPI     protein phosphatase binding GO:0019903 IPI     neurotrophin TRKA receptor binding GO:0005168 IPI     insulin receptor substrate binding GO:0043560 ISS     1-phosphatidylinositol-3-kinase regulator activity GO:0046935 IBA     phosphatidylinositol 3-kinase binding GO:0043548 ISS     insulin binding GO:0043559 IDA Biological Process     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS     negative regulation of osteoclast differentiation GO:0045671 IEA     protein phosphorylation GO:0006468 IEA     cellular glucose homeostasis GO:0001678 ISS     positive regulation of tumor necrosis factor production GO:0032760 IEA     positive regulation of glucose import GO:0046326 ISS     positive regulation of cell migration GO:0030335 IEA     insulin receptor signaling pathway GO:0008286 TAS     regulation of phosphatidylinositol 3-kinase activity GO:0043551 ISS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     viral process GO:0016032 IEA     insulin-like growth factor receptor signaling pathway GO:0048009 IPI     negative regulation of cell-matrix adhesion GO:0001953 IEA     T cell costimulation GO:0031295 TAS     phosphatidylinositol-mediated signaling GO:0048015 TAS     blood coagulation GO:0007596 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     positive regulation of RNA splicing GO:0033120 IMP     B cell differentiation GO:0030183 IEA     response to endoplasmic reticulum stress GO:0034976 ISS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     cellular response to insulin stimulus GO:0032869 ISS     cellular response to UV GO:0034644 IEA     positive regulation of establishment of protein localization to plasma membrane GO:0090004 ISS     phosphatidylinositol 3-kinase signaling GO:0014065 IDA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IEA     growth hormone receptor signaling pathway GO:0060396 IDA     phosphatidylinositol phosphorylation GO:0046854 ISS     positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 IMP     protein stabilization GO:0050821 IDA     platelet activation GO:0030168 TAS     leukocyte migration GO:0050900 TAS     NFAT protein import into nucleus GO:0051531 IEA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA     small molecule metabolic process GO:0044281 TAS     negative regulation of apoptotic process GO:0043066 IMP     positive regulation of transcription factor import into nucleus GO:0042993 ISS     phospholipid metabolic process GO:0006644 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     T cell receptor signaling pathway GO:0050852 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     phosphatidylinositol biosynthetic process GO:0006661 TAS     innate immune response GO:0045087 TAS Subcellular Localization     phosphatidylinositol 3-kinase complex, class IA GO:0005943 ISS     plasma membrane GO:0005886 TAS     nucleus GO:0005634 ISS     membrane GO:0016020 IDA     cytoplasm GO:0005737 IDA     cell-cell junction GO:0005911 IEA     cytosol GO:0005829 TAS     phosphatidylinositol 3-kinase complex GO:0005942 ISS