Gene description for SYNM
Gene name synemin, intermediate filament protein
Gene symbol SYNM
Other names/aliases DMN
SYN
Species Homo sapiens
 Database cross references - SYNM
ExoCarta ExoCarta_23336
Entrez Gene 23336
HGNC 24466
MIM 606087
UniProt O15061  
 SYNM identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SYNM
Molecular Function
    intermediate filament binding GO:0019215 ISS
    structural constituent of cytoskeleton GO:0005200 IDA
    vinculin binding GO:0017166 IDA
    protein binding GO:0005515 IPI
    structural constituent of muscle GO:0008307 IDA
Biological Process
    intermediate filament cytoskeleton organization GO:0045104 TAS
Subcellular Localization
    costamere GO:0043034 IDA
    intermediate filament GO:0005882 NAS
    neurofilament cytoskeleton GO:0060053 TAS
    membrane GO:0016020 IEA
    adherens junction GO:0005912 IDA
 Experiment description of studies that identified SYNM in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SYNM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DTNA  
Reconstituted Complex Homo sapiens
2 DES 1674
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SYNM is involved
No pathways found





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