Gene description for FKBP8
Gene name FK506 binding protein 8, 38kDa
Gene symbol FKBP8
Other names/aliases FKBP38
FKBPr38
Species Homo sapiens
 Database cross references - FKBP8
ExoCarta ExoCarta_23770
Entrez Gene 23770
HGNC 3724
MIM 604840
UniProt Q14318  
 FKBP8 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for FKBP8
Molecular Function
    metal ion binding GO:0046872 IEA
    identical protein binding GO:0042802 IPI
    FK506 binding GO:0005528 IBA
    protein binding GO:0005515 IPI
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
Biological Process
    negative regulation of apoptotic process GO:0043066 IEA
    protein peptidyl-prolyl isomerization GO:0000413 IBA
    chaperone-mediated protein folding GO:0061077 IBA
    intracellular signal transduction GO:0035556 TAS
    multicellular organism growth GO:0035264 IEA
    apoptotic process GO:0006915 IEA
    positive regulation of BMP signaling pathway GO:0030513 IEA
    smoothened signaling pathway GO:0007224 IEA
    viral process GO:0016032 IEA
    cell fate specification GO:0001708 IEA
    regulation of gene expression GO:0010468 IEA
    dorsal/ventral neural tube patterning GO:0021904 IEA
    camera-type eye development GO:0043010 IEA
Subcellular Localization
    integral component of endoplasmic reticulum membrane GO:0030176 IEA
    membrane GO:0016020 IDA
    mitochondrial membrane GO:0031966 IEA
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum membrane GO:0005789 IBA
 Experiment description of studies that identified FKBP8 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for FKBP8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCL2L1  
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 BCL2  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 PPP3CA 5530
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which FKBP8 is involved
No pathways found





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