Gene description for SCFD1
Gene name sec1 family domain containing 1
Gene symbol SCFD1
Other names/aliases C14orf163
Species Homo sapiens
 Database cross references - SCFD1
ExoCarta ExoCarta_23256
Entrez Gene 23256
HGNC 20726
UniProt Q8WVM8  
 SCFD1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SCFD1
Molecular Function
    protein binding GO:0005515 IPI
    protein N-terminus binding GO:0047485 IEA
    syntaxin binding GO:0019905 ISS
Biological Process
    cell morphogenesis GO:0000902 ISS
    negative regulation of autophagosome assembly GO:1902902 IMP
    response to toxic substance GO:0009636 IEP
    retrograde vesicle-mediated transport, Golgi to ER GO:0006890 ISS
    post-Golgi vesicle-mediated transport GO:0006892 ISS
    regulation of ER to Golgi vesicle-mediated transport GO:0060628 ISS
    protein transport GO:0015031 IEA
    regulation of protein transport GO:0051223 IMP
    vesicle docking involved in exocytosis GO:0006904 IEA
    phagocytosis GO:0006909 ISS
    response to hypoxia GO:0001666 IEA
Subcellular Localization
    Golgi cisterna membrane GO:0032580 IEA
    cis-Golgi network GO:0005801 IDA
    SNARE complex GO:0031201 ISS
    Golgi transport complex GO:0017119 ISS
    Golgi-associated vesicle GO:0005798 ISS
    plasma membrane GO:0005886 ISS
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified SCFD1 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SCFD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VCL 7414
Affinity Capture-MS Homo sapiens
2 USO1 8615
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 XRN2 22803
Affinity Capture-MS Homo sapiens
4 DLST 1743
Two-hybrid Homo sapiens
5 STX18  
Affinity Capture-MS Homo sapiens
6 USP22 23326
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SCFD1 is involved
No pathways found

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