Gene description for YIPF5
Gene name Yip1 domain family, member 5
Gene symbol YIPF5
Other names/aliases FinGER5
SB140
SMAP-5
SMAP5
YIP1A
Species Homo sapiens
 Database cross references - YIPF5
ExoCarta ExoCarta_81555
Vesiclepedia VP_81555
Entrez Gene 81555
HGNC 24877
MIM 611483
UniProt Q969M3  
 YIPF5 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for YIPF5
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    protein transport GO:0015031 IEA
    insulin processing GO:0030070 IMP
    vesicle fusion with Golgi apparatus GO:0048280 IBA
    regulation of ER to Golgi vesicle-mediated transport GO:0060628 IBA
    regulation of ER to Golgi vesicle-mediated transport GO:0060628 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IBA
    COPII-coated ER to Golgi transport vesicle GO:0030134 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    endoplasmic reticulum exit site GO:0070971 IEA
 Experiment description of studies that identified YIPF5 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for YIPF5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SPRTN  
Affinity Capture-MS Homo sapiens
3 ARID5B 84159
Affinity Capture-MS Homo sapiens
4 RAB1A 5861
Affinity Capture-MS Homo sapiens
5 Psmb5 19173
Affinity Capture-MS Mus musculus
6 TMEM161A  
Affinity Capture-MS Homo sapiens
7 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 NAPA 8775
Affinity Capture-MS Homo sapiens
9 TMED4 222068
Affinity Capture-MS Homo sapiens
10 TMED5 50999
Affinity Capture-MS Homo sapiens
11 ADRB2  
Two-hybrid Homo sapiens
12 SLC1A1 6505
Affinity Capture-MS Homo sapiens
13 SLC2A1 6513
Affinity Capture-MS Homo sapiens
14 NABP2  
Affinity Capture-MS Homo sapiens
15 UBC 7316
Reconstituted Complex Homo sapiens
16 TMEM72  
Affinity Capture-MS Homo sapiens
17 FFAR1  
Affinity Capture-MS Homo sapiens
18 SLC38A5 92745
Affinity Capture-MS Homo sapiens
19 GP5 2814
Affinity Capture-MS Homo sapiens
20 TAF9 6880
Affinity Capture-MS Homo sapiens
21 PRKCDBP 112464
Affinity Capture-MS Homo sapiens
22 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
23 TMED2 10959
Affinity Capture-MS Homo sapiens
24 SLC6A5  
Affinity Capture-MS Homo sapiens
25 RER1 11079
Affinity Capture-MS Homo sapiens
26 TMEM115 11070
Affinity Capture-MS Homo sapiens
27 ATP5O 539
Affinity Capture-MS Homo sapiens
28 PHB 5245
Affinity Capture-MS Homo sapiens
29 LMAN2 10960
Affinity Capture-MS Homo sapiens
30 SEC23A 10484
Affinity Capture-MS Homo sapiens
31 SSR3 6747
Affinity Capture-MS Homo sapiens
32 FAF2 23197
Affinity Capture-MS Homo sapiens
33 FAM20C 56975
Affinity Capture-MS Homo sapiens
34 TMEM63B 55362
Affinity Capture-MS Homo sapiens
35 RAB1B 81876
Affinity Capture-MS Homo sapiens
36 ATP5A1 498
Affinity Capture-MS Homo sapiens
37 SCFD1 23256
Affinity Capture-MS Homo sapiens
38 HS2ST1 9653
Affinity Capture-MS Homo sapiens
39 SLC1A5 6510
Affinity Capture-MS Homo sapiens
40 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
41 P2RY8  
Affinity Capture-MS Homo sapiens
42 PSMD14 10213
Affinity Capture-MS Homo sapiens
43 GPR35  
Affinity Capture-MS Homo sapiens
44 Pfdn2  
Affinity Capture-MS Mus musculus
45 TUBA1C 84790
Affinity Capture-MS Homo sapiens
46 YIF1A 10897
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
47 SFT2D3  
Affinity Capture-MS Homo sapiens
48 GPR182  
Affinity Capture-MS Homo sapiens
49 RAB3GAP1 22930
Affinity Capture-MS Homo sapiens
50 PIGS 94005
Affinity Capture-MS Homo sapiens
51 CD63 967
Affinity Capture-MS Homo sapiens
52 ATP2C1 27032
Affinity Capture-MS Homo sapiens
53 ELOVL5 60481
Affinity Capture-MS Homo sapiens
54 ATP5B 506
Affinity Capture-MS Homo sapiens
55 PTAR1 375743
Affinity Capture-MS Homo sapiens
56 Cep131  
Affinity Capture-MS Mus musculus
57 REEP5 7905
Affinity Capture-MS Homo sapiens
58 NUCB2 4925
Affinity Capture-MS Homo sapiens
59 MGARP  
Affinity Capture-MS Homo sapiens
60 Hsf1  
Affinity Capture-MS Mus musculus
61 COX5B 1329
Affinity Capture-MS Homo sapiens
62 PANX1 24145
Proximity Label-MS Homo sapiens
63 Atp2a2 11938
Affinity Capture-MS Mus musculus
64 SAR1A 56681
Affinity Capture-MS Homo sapiens
65 GOLT1B 51026
Affinity Capture-MS Homo sapiens
66 P2RY2 5029
Affinity Capture-MS Homo sapiens
67 MBOAT1  
Affinity Capture-MS Homo sapiens
68 BCAP31 10134
Affinity Capture-MS Homo sapiens
69 COX6B1 1340
Affinity Capture-MS Homo sapiens
70 RCN1 5954
Affinity Capture-MS Homo sapiens
71 Cdc16  
Affinity Capture-MS Mus musculus
72 TMEM173  
Affinity Capture-MS Homo sapiens
73 MFSD11  
Affinity Capture-MS Homo sapiens
74 FAM134C 162427
Affinity Capture-MS Homo sapiens
75 RABAC1 10567
Affinity Capture-MS Homo sapiens
76 Uso1 56041
Affinity Capture-MS Mus musculus
77 TMCO1 54499
Affinity Capture-MS Homo sapiens
78 TMED7 51014
Affinity Capture-MS Homo sapiens
79 ACKR2  
Affinity Capture-MS Homo sapiens
80 SLC30A7 148867
Affinity Capture-MS Homo sapiens
81 MSN 4478
Affinity Capture-MS Homo sapiens
82 HSD17B12 51144
Affinity Capture-MS Homo sapiens
83 CEPT1 10390
Affinity Capture-MS Homo sapiens
84 YIF1B 90522
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 RAB18 22931
Affinity Capture-MS Homo sapiens
86 SEC24B 10427
Affinity Capture-MS Homo sapiens
87 MBOAT7 79143
Affinity Capture-MS Homo sapiens
88 CLPP 8192
Proximity Label-MS Homo sapiens
89 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
90 PHB2 11331
Affinity Capture-MS Homo sapiens
91 Ercc6l  
Affinity Capture-MS Mus musculus
92 TMEM57  
Affinity Capture-MS Homo sapiens
93 RAB3GAP2 25782
Affinity Capture-MS Homo sapiens
94 NSF 4905
Affinity Capture-MS Homo sapiens
95 ATP5J 522
Affinity Capture-MS Homo sapiens
96 TP53 7157
Affinity Capture-MS Homo sapiens
97 ERP44 23071
Affinity Capture-MS Homo sapiens
98 Atp7a  
Affinity Capture-MS Mus musculus
99 RTN3 10313
Affinity Capture-MS Homo sapiens
100 Pcgf1  
Affinity Capture-MS Mus musculus
101 IER3IP1 51124
Affinity Capture-MS Homo sapiens
102 TSPAN15 23555
Affinity Capture-MS Homo sapiens
103 LMAN2L 81562
Affinity Capture-MS Homo sapiens
104 UNC93B1 81622
Affinity Capture-MS Homo sapiens
105 MCFD2 90411
Affinity Capture-MS Homo sapiens
106 RABL3 285282
Affinity Capture-MS Homo sapiens
107 RAB2A 5862
Affinity Capture-MS Homo sapiens
108 SEC62 7095
Proximity Label-MS Homo sapiens
109 NDC1 55706
Affinity Capture-MS Homo sapiens
110 STX3 6809
Affinity Capture-MS Homo sapiens
111 SPPL2B 56928
Affinity Capture-MS Homo sapiens
112 RAB7A 7879
Affinity Capture-MS Homo sapiens
113 ATP1A1 476
Affinity Capture-MS Homo sapiens
114 SEC22A  
Affinity Capture-MS Homo sapiens
115 CYB5R3 1727
Affinity Capture-MS Homo sapiens
116 EI24  
Affinity Capture-MS Homo sapiens
117 Tnpo1 238799
Affinity Capture-MS Mus musculus
118 VIPR1  
Affinity Capture-MS Homo sapiens
119 RAB5C 5878
Affinity Capture-MS Homo sapiens
120 C9orf72  
Affinity Capture-MS Homo sapiens
121 PRAF2 11230
Affinity Capture-MS Homo sapiens
122 PTRF 284119
Affinity Capture-MS Homo sapiens
123 RAB2B 84932
Affinity Capture-MS Homo sapiens
124 CAV1 857
Affinity Capture-MS Homo sapiens
125 ESYT1 23344
Affinity Capture-MS Homo sapiens
126 S1PR4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which YIPF5 is involved
No pathways found





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