Gene description for RABL3
Gene name RAB, member of RAS oncogene family-like 3
Gene symbol RABL3
Other names/aliases -
Species Homo sapiens
 Database cross references - RABL3
ExoCarta ExoCarta_285282
Vesiclepedia VP_285282
Entrez Gene 285282
HGNC 18072
UniProt Q5HYI8  
 RABL3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RABL3
Molecular Function
    GTPase activity GO:0003924 IBA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 ISS
    protein homodimerization activity GO:0042803 ISS
Biological Process
    natural killer cell differentiation GO:0001779 ISS
    intracellular protein transport GO:0006886 IBA
    B cell differentiation GO:0030183 ISS
    T cell differentiation in thymus GO:0033077 ISS
    regulation of Ras protein signal transduction GO:0046578 IMP
    protein stabilization GO:0050821 ISS
    regulation of protein lipidation GO:1903059 IMP
Subcellular Localization
    endomembrane system GO:0012505 IBA
 Experiment description of studies that identified RABL3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RABL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LHFPL4  
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 Tmed2 56334
Affinity Capture-MS Mus musculus
4 C5AR1  
Affinity Capture-MS Homo sapiens
5 DHCR24 1718
Affinity Capture-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 SYNGR1 9145
Affinity Capture-MS Homo sapiens
9 GJA1 2697
Proximity Label-MS Homo sapiens
10 ACKR2  
Affinity Capture-MS Homo sapiens
11 TMEM184A  
Affinity Capture-MS Homo sapiens
12 Atp2a2 11938
Affinity Capture-MS Mus musculus
13 GJD3  
Proximity Label-MS Homo sapiens
14 LAMP2 3920
Proximity Label-MS Homo sapiens
15 DNAJC25 548645
Proximity Label-MS Homo sapiens
16 PTPN1 5770
Proximity Label-MS Homo sapiens
17 Ktn1  
Affinity Capture-MS Mus musculus
18 SIRT5 23408
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 APP 351
Reconstituted Complex Homo sapiens
20 KDELR1 10945
Affinity Capture-MS Homo sapiens
21 SERINC2 347735
Affinity Capture-MS Homo sapiens
22 PIGN 23556
Affinity Capture-MS Homo sapiens
23 B3GAT1  
Proximity Label-MS Homo sapiens
24 RAB3B 5865
Proximity Label-MS Homo sapiens
25 TMED2 10959
Affinity Capture-MS Homo sapiens
26 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
27 SSR1 6745
Proximity Label-MS Homo sapiens
28 RHOA 387
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 STX6 10228
Proximity Label-MS Homo sapiens
30 SLC25A46 91137
Proximity Label-MS Homo sapiens
31 RAB35 11021
Proximity Label-MS Homo sapiens
32 PKN2 5586
Affinity Capture-MS Homo sapiens
33 EBAG9 9166
Proximity Label-MS Homo sapiens
34 MARCKS 4082
Proximity Label-MS Homo sapiens
35 TMEM63B 55362
Affinity Capture-MS Homo sapiens
36 LMAN1 3998
Proximity Label-MS Homo sapiens
37 NUP155 9631
Proximity Label-MS Homo sapiens
38 KIAA1715 80856
Proximity Label-MS Homo sapiens
39 PXMP2  
Proximity Label-MS Homo sapiens
40 RAB5A 5868
Proximity Label-MS Homo sapiens
41 PANX1 24145
Proximity Label-MS Homo sapiens
42 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
43 EMD 2010
Proximity Label-MS Homo sapiens
44 CXADR 1525
Proximity Label-MS Homo sapiens
45 STOM 2040
Affinity Capture-MS Homo sapiens
46 P2RY8  
Affinity Capture-MS Homo sapiens
47 RAB4A 5867
Proximity Label-MS Homo sapiens
48 SLC43A3 29015
Affinity Capture-MS Homo sapiens
49 SCAMP2 10066
Affinity Capture-MS Homo sapiens
50 RPN1 6184
Proximity Label-MS Homo sapiens
51 AQP12B  
Affinity Capture-MS Homo sapiens
52 MAPK8 5599
Affinity Capture-MS Homo sapiens
53 RHOT2 89941
Proximity Label-MS Homo sapiens
54 ELOVL5 60481
Proximity Label-MS Homo sapiens
55 GPR173  
Affinity Capture-MS Homo sapiens
56 SEC61B 10952
Proximity Label-MS Homo sapiens
57 FGFR1OP  
Affinity Capture-MS Homo sapiens
58 RMDN3 55177
Proximity Label-MS Homo sapiens
59 PTAR1 375743
Synthetic Lethality Homo sapiens
60 REEP5 7905
Proximity Label-MS Homo sapiens
61 RELL1 768211
Affinity Capture-MS Homo sapiens
62 SEC63 11231
Proximity Label-MS Homo sapiens
63 P2RY2 5029
Affinity Capture-MS Homo sapiens
64 VIPR2  
Affinity Capture-MS Homo sapiens
65 RAP1GDS1 5910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 RPN2 6185
Proximity Label-MS Homo sapiens
67 ATL3 25923
Affinity Capture-MS Homo sapiens
68 LRRC59 55379
Proximity Label-MS Homo sapiens
69 LMNB1 4001
Proximity Label-MS Homo sapiens
70 SLC35C1  
Affinity Capture-MS Homo sapiens
71 LAMP1 3916
Proximity Label-MS Homo sapiens
72 Bmpr1a  
Affinity Capture-MS Mus musculus
73 GOLT1B 51026
Affinity Capture-MS Homo sapiens
74 Rmdn3  
Affinity Capture-MS Mus musculus
75 BCAP31 10134
Proximity Label-MS Homo sapiens
76 HSD3B7 80270
Proximity Label-MS Homo sapiens
77 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
78 NR3C1 2908
Proximity Label-MS Homo sapiens
79 STIM1 6786
Proximity Label-MS Homo sapiens
80 FKBP8 23770
Proximity Label-MS Homo sapiens
81 ARHGEF16 27237
Affinity Capture-MS Homo sapiens
82 YIPF5 81555
Affinity Capture-MS Homo sapiens
83 Uso1 56041
Affinity Capture-MS Mus musculus
84 ATP2A1 487
Proximity Label-MS Homo sapiens
85 GPR45  
Affinity Capture-MS Homo sapiens
86 RAB9A 9367
Proximity Label-MS Homo sapiens
87 CYP2C9  
Proximity Label-MS Homo sapiens
88 MALL  
Affinity Capture-MS Homo sapiens
89 PTAFR  
Affinity Capture-MS Homo sapiens
90 RNF43  
Proximity Label-MS Homo sapiens
91 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
92 FASN 2194
Negative Genetic Homo sapiens
93 TMED10 10972
Affinity Capture-MS Homo sapiens
94 GPR89A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 TMEM208  
Affinity Capture-MS Homo sapiens
96 VAMP4 8674
Affinity Capture-MS Homo sapiens
97 TSPAN15 23555
Affinity Capture-MS Homo sapiens
98 AGPAT3 56894
Affinity Capture-MS Homo sapiens
99 ERGIC1 57222
Proximity Label-MS Homo sapiens
100 ARF4 378
Proximity Label-MS Homo sapiens
101 CAV3 859
Affinity Capture-MS Homo sapiens
102 ERGIC2 51290
Proximity Label-MS Homo sapiens
103 EDA  
Affinity Capture-MS Homo sapiens
104 SEC62 7095
Proximity Label-MS Homo sapiens
105 RAB7A 7879
Proximity Label-MS Homo sapiens
106 RAB11A 8766
Proximity Label-MS Homo sapiens
107 CERS4  
Affinity Capture-MS Homo sapiens
108 DNAJC1 64215
Proximity Label-MS Homo sapiens
109 RAB5C 5878
Proximity Label-MS Homo sapiens
110 CKAP4 10970
Proximity Label-MS Homo sapiens
111 CAV1 857
Affinity Capture-MS Homo sapiens
112 FPR2  
Affinity Capture-MS Homo sapiens
113 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RABL3 is involved
No pathways found





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