Gene description for PANX1
Gene name	pannexin 1
Gene symbol	PANX1
Other names/aliases	MRS1 PX1 UNQ2529
Species	Homo sapiens
Database cross references - PANX1
ExoCarta	ExoCarta_24145
Entrez Gene	24145
HGNC	8599
MIM	608420
UniProt	Q96RD7
PANX1 identified in exosomes derived from the following tissue/cell type
Melanoma cells	25950383
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for PANX1

Molecular Function     gap junction hemi-channel activity GO:0055077 IDA     protein heterodimerization activity GO:0046982 IEA     protease binding GO:0002020 IEA     receptor binding GO:0005102 IPI     calcium channel activity GO:0005262 IMP     ion channel binding GO:0044325 IEA     actin filament binding GO:0051015 IEA     scaffold protein binding GO:0097110 IEA     leak channel activity GO:0022840 IMP Biological Process     innate immune response GO:0045087 TAS     positive regulation of interleukin-1 beta secretion GO:0050718 IDA     calcium ion transport GO:0006816 IMP     synaptic transmission GO:0007268 TAS     positive regulation of interleukin-1 alpha secretion GO:0050717 IEA     response to ischemia GO:0002931 IEA     cell-cell signaling GO:0007267 IBA     protein hexamerization GO:0034214 IDA     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     cation transport GO:0006812 IDA     calcium ion transmembrane transport GO:0070588 IEA     response to ATP GO:0033198 IEA Subcellular Localization     endoplasmic reticulum membrane GO:0005789 IEA     protein complex GO:0043234 IEA     bleb GO:0032059 IDA     endoplasmic reticulum GO:0005783 IDA     membrane GO:0016020 IDA     integral component of membrane GO:0016021 IEA     plasma membrane GO:0005886 TAS     gap junction GO:0005921 IEA