Gene description for ADCY9
Gene name adenylate cyclase 9
Gene symbol ADCY9
Other names/aliases AC9
Species Homo sapiens
 Database cross references - ADCY9
ExoCarta ExoCarta_115
Entrez Gene 115
HGNC 240
MIM 603302
UniProt O60503  
 ADCY9 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ADCY9
Molecular Function
    metal ion binding GO:0046872 IEA
    adenylate cyclase activity GO:0004016 IEA
    ATP binding GO:0005524 IEA
Biological Process
    synaptic transmission GO:0007268 TAS
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    activation of protein kinase A activity GO:0034199 TAS
    water transport GO:0006833 TAS
    cAMP biosynthetic process GO:0006171 IEA
    signal transduction GO:0007165 TAS
    activation of phospholipase C activity GO:0007202 TAS
    intracellular signal transduction GO:0035556 IEA
    energy reserve metabolic process GO:0006112 TAS
    cellular response to glucagon stimulus GO:0071377 TAS
    renal water homeostasis GO:0003091 TAS
    innate immune response GO:0045087 TAS
    transmembrane transport GO:0055085 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    small molecule metabolic process GO:0044281 TAS
    adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
    intracellular GO:0005622 IEA
 Experiment description of studies that identified ADCY9 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ADCY9
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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