Gene description for ZMYND8
Gene name zinc finger, MYND-type containing 8
Gene symbol ZMYND8
Other names/aliases PRKCBP1
PRO2893
RACK7
Species Homo sapiens
 Database cross references - ZMYND8
ExoCarta ExoCarta_23613
Entrez Gene 23613
HGNC 9397
MIM 615713
UniProt Q9ULU4  
 ZMYND8 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZMYND8
Molecular Function
    RNA polymerase II transcription corepressor activity GO:0001106 ISS
    repressing transcription factor binding GO:0070491 ISS
    zinc ion binding GO:0008270 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
 Experiment description of studies that identified ZMYND8 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZMYND8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FHOD1 29109
Two-hybrid Homo sapiens
2 PRKCB 5579
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which ZMYND8 is involved
No pathways found





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