Gene description for CTNNBL1
Gene name catenin, beta like 1
Gene symbol CTNNBL1
Other names/aliases C20orf33
NAP
P14L
PP8304
dJ633O20.1
Species Homo sapiens
 Database cross references - CTNNBL1
ExoCarta ExoCarta_56259
Vesiclepedia VP_56259
Entrez Gene 56259
HGNC 15879
MIM 611537
UniProt Q8WYA6  
 CTNNBL1 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CTNNBL1
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
Biological Process
    mRNA splicing, via spliceosome GO:0000398 NAS
    adaptive immune response GO:0002250 IEA
    somatic diversification of immunoglobulins GO:0016445 IMP
    positive regulation of apoptotic process GO:0043065 IDA
Subcellular Localization
    Prp19 complex GO:0000974 IDA
    Prp19 complex GO:0000974 IPI
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IBA
    spliceosomal complex GO:0005681 IDA
    spliceosomal complex GO:0005681 IPI
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified CTNNBL1 in exosomes
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CTNNBL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPC 3183
Co-fractionation Homo sapiens
2 CLEC3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 KPNA1 3836
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 DUXAP10  
Affinity Capture-MS Homo sapiens
5 PPIE 10450
Affinity Capture-MS Homo sapiens
6 KCTD10 83892
Affinity Capture-MS Homo sapiens
7 RPA2 6118
Proximity Label-MS Homo sapiens
8 CTNNBL1 56259
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
9 RPL35A 6165
Affinity Capture-MS Homo sapiens
10 PRPF3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 KPNA2 3838
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
12 SNRPF 6636
Affinity Capture-MS Homo sapiens
13 CDCA7L  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 HSPA4 3308
Affinity Capture-MS Homo sapiens
15 SNRNP70 6625
Co-fractionation Homo sapiens
16 CRNKL1 51340
Affinity Capture-MS Homo sapiens
17 ISY1 57461
Affinity Capture-MS Homo sapiens
18 NPM1 4869
Affinity Capture-MS Homo sapiens
19 SNRPC 6631
Affinity Capture-MS Homo sapiens
20 SF3A2 8175
Affinity Capture-MS Homo sapiens
21 HIST4H4 121504
Affinity Capture-MS Homo sapiens
22 CWC15  
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
23 ATG16L1 55054
Affinity Capture-MS Homo sapiens
24 MECP2 4204
Affinity Capture-MS Homo sapiens
25 BUD31 8896
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 KIF3A 11127
Affinity Capture-MS Homo sapiens
27 MED4 29079
Two-hybrid Homo sapiens
28 ZNF394  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 RPS9 6203
Affinity Capture-MS Homo sapiens
30 DDX21 9188
Affinity Capture-MS Homo sapiens
31 SRPK2 6733
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 PARK2  
Affinity Capture-MS Homo sapiens
33 RBM6 10180
Affinity Capture-MS Homo sapiens
34 THAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SNRNP200 23020
Co-fractionation Homo sapiens
36 PPP1R8 5511
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 GGH 8836
Affinity Capture-MS Homo sapiens
38 CENPM  
Affinity Capture-MS Homo sapiens
39 RAD18  
Affinity Capture-MS Homo sapiens
40 ERP29 10961
Two-hybrid Homo sapiens
41 MEOX2  
Two-hybrid Homo sapiens
42 BCL6  
Affinity Capture-MS Homo sapiens
43 SNRNP27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 STAMBP 10617
Two-hybrid Homo sapiens
45 PRPF31 26121
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
46 DUSP23 54935
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PLRG1 5356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 VCP 7415
Affinity Capture-MS Homo sapiens
49 RNF40 9810
Affinity Capture-MS Homo sapiens
50 RBM39 9584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PRPF4B 8899
Affinity Capture-MS Homo sapiens
52 CATIP  
Two-hybrid Homo sapiens
53 SIRT7  
Affinity Capture-MS Homo sapiens
54 HOXB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SNRPB 6628
Affinity Capture-MS Homo sapiens
56 NGFRAP1  
Two-hybrid Homo sapiens
57 U2AF2 11338
Co-fractionation Homo sapiens
58 CUL3 8452
Affinity Capture-MS Homo sapiens
59 XAB2 56949
Affinity Capture-MS Homo sapiens
60 CYP1A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 SF3A1 10291
Affinity Capture-MS Homo sapiens
62 PRMT5 10419
Affinity Capture-MS Homo sapiens
63 RPA3 6119
Proximity Label-MS Homo sapiens
64 NSRP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
65 ZMYM6  
Affinity Capture-MS Homo sapiens
66 STAT1 6772
Affinity Capture-MS Homo sapiens
67 PRPF19 27339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 HECW2  
Affinity Capture-MS Homo sapiens
69 ZMYND8 23613
Affinity Capture-MS Homo sapiens
70 EGFR 1956
Negative Genetic Homo sapiens
71 TOP1 7150
Affinity Capture-MS Homo sapiens
72 RBM45  
Affinity Capture-MS Homo sapiens
73 U2SURP 23350
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
74 SURF6  
Affinity Capture-MS Homo sapiens
75 ZNF689  
Affinity Capture-MS Homo sapiens
76 BCAS2 10286
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
77 BKRF1  
Affinity Capture-MS
78 WDR77 79084
Affinity Capture-MS Homo sapiens
79 Cdc5l 71702
Affinity Capture-MS Mus musculus
80 HSPA8 3312
Co-fractionation Homo sapiens
81 WBP11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 SPP1 6696
Two-hybrid Homo sapiens
83 HNRNPA2B1 3181
Co-fractionation Homo sapiens
84 SNRPA 6626
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
85 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 CXCL14  
Affinity Capture-MS Homo sapiens
87 AICDA  
Affinity Capture-Western Homo sapiens
88 G3BP1 10146
Affinity Capture-MS Homo sapiens
89 CREBZF  
Two-hybrid Homo sapiens
90 MKI67  
Affinity Capture-MS Homo sapiens
91 HNRNPK 3190
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
92 TBK1 29110
Affinity Capture-Western Homo sapiens
93 NEIL1  
Affinity Capture-MS Homo sapiens
94 ACTA1 58
Affinity Capture-MS Homo sapiens
95 IK 3550
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
96 RPS24 6229
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 ZCCHC10  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
98 CIT 11113
Affinity Capture-MS Homo sapiens
99 LDOC1  
Two-hybrid Homo sapiens
100 SERBP1 26135
Affinity Capture-MS Homo sapiens
101 SNW1 22938
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
102 KRAS 3845
Negative Genetic Homo sapiens
103 ZNF331  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 USP47 55031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 LUC7L 55692
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
106 PRDM4  
Two-hybrid Homo sapiens
107 ZNF830  
Affinity Capture-MS Homo sapiens
108 CDC5L 988
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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