Gene description for CRNKL1
Gene name crooked neck pre-mRNA splicing factor 1
Gene symbol CRNKL1
Other names/aliases CLF
CRN
Clf1
HCRN
MSTP021
SYF3
Species Homo sapiens
 Database cross references - CRNKL1
ExoCarta ExoCarta_51340
Entrez Gene 51340
HGNC 15762
MIM 610952
UniProt Q9BZJ0  
 CRNKL1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CRNKL1
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    RNA binding GO:0003723 IDA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IC
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    positive regulation of defense response to virus by host GO:0002230 IMP
    spliceosomal complex assembly GO:0000245 IDA
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 IDA
    cytoplasm GO:0005737 IEA
    spliceosomal complex GO:0005681 IDA
    nuclear speck GO:0016607 IEA
 Experiment description of studies that identified CRNKL1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CRNKL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CRNKL1 is involved
No pathways found





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