Gene description for SNRPA
Gene name small nuclear ribonucleoprotein polypeptide A
Gene symbol SNRPA
Other names/aliases Mud1
U1-A
U1A
Species Homo sapiens
 Database cross references - SNRPA
ExoCarta ExoCarta_6626
Vesiclepedia VP_6626
Entrez Gene 6626
HGNC 11151
MIM 182285
UniProt P09012  
 SNRPA identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SNRPA
Molecular Function
    DNA binding GO:0003677 EXP
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    protein binding GO:0005515 IPI
    U1 snRNA binding GO:0030619 IBA
    U1 snRNA binding GO:0030619 IDA
    identical protein binding GO:0042802 IPI
    U1 snRNP binding GO:1990446 IEA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IBA
    mRNA splicing, via spliceosome GO:0000398 IC
    mRNA splicing, via spliceosome GO:0000398 NAS
Subcellular Localization
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IDA
    spliceosomal complex GO:0005681 IPI
    U1 snRNP GO:0005685 IBA
    U1 snRNP GO:0005685 IDA
    U1 snRNP GO:0005685 IPI
    U4/U6 x U5 tri-snRNP complex GO:0046540 IPI
 Experiment description of studies that identified SNRPA in exosomes
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNRPA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PQBP1  
Affinity Capture-MS Homo sapiens
2 Celf1  
Two-hybrid Mus musculus
3 ZNF346  
Affinity Capture-MS Homo sapiens
4 PCF11 51585
Affinity Capture-MS Homo sapiens
5 PRPF8 10594
Affinity Capture-MS Homo sapiens
6 SRPK2 6733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 FAM208A  
Affinity Capture-MS Homo sapiens
8 DDX17 10521
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
9 EBNA-LP  
Affinity Capture-MS
10 UBC 7316
Reconstituted Complex Homo sapiens
11 THOC7 80145
Affinity Capture-MS Homo sapiens
12 SCAF4 57466
Affinity Capture-MS Homo sapiens
13 PRPF40A 55660
Affinity Capture-MS Homo sapiens
14 GCN1L1 10985
Co-fractionation Homo sapiens
15 PRKDC 5591
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
16 PCBP3 54039
Two-hybrid Homo sapiens
17 DDX23 9416
Affinity Capture-MS Homo sapiens
18 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
19 SNRNP70 6625
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
20 CRNKL1 51340
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
21 USP39 10713
Affinity Capture-MS Homo sapiens
22 CPSF7 79869
Affinity Capture-MS Homo sapiens
23 TFIP11  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
24 Kif3c  
Two-hybrid Mus musculus
25 SNRPD3 6634
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
26 POLR2C 5432
Affinity Capture-MS Homo sapiens
27 SFN 2810
Affinity Capture-MS Homo sapiens
28 SMAD5 4090
Two-hybrid Homo sapiens
29 HUWE1 10075
Affinity Capture-MS Homo sapiens
30 ARIH2 10425
Affinity Capture-MS Homo sapiens
31 BUD31 8896
Affinity Capture-MS Homo sapiens
32 SLU7  
Co-fractionation Homo sapiens
33 EEF1A1 1915
Co-fractionation Homo sapiens
34 RBMX 27316
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
35 CHMP4C 92421
Affinity Capture-MS Homo sapiens
36 AURKA 6790
Affinity Capture-MS Homo sapiens
37 WBP4  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
38 LIN28B  
Affinity Capture-MS Homo sapiens
39 SUPT5H 6829
Affinity Capture-MS Homo sapiens
40 CSTF2 1478
Affinity Capture-MS Homo sapiens
41 C17orf85  
Affinity Capture-MS Homo sapiens
42 RBM7  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
43 DDX20 11218
Affinity Capture-MS Homo sapiens
44 PABPC1 26986
Co-fractionation Homo sapiens
45 CARM1 10498
Co-fractionation Homo sapiens
46 OGT 8473
Affinity Capture-MS Homo sapiens
47 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
48 CUL2 8453
Affinity Capture-MS Homo sapiens
49 SRPK3  
Affinity Capture-MS Homo sapiens
50 SON 6651
Affinity Capture-MS Homo sapiens
51 DDX39B 7919
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
52 SRPK1 6732
Affinity Capture-MS Homo sapiens
53 TRA2B 6434
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
54 CCDC12  
Affinity Capture-MS Homo sapiens
55 ZNF326 284695
Affinity Capture-MS Homo sapiens
56 BCLAF1 9774
Affinity Capture-MS Homo sapiens
57 CISD1 55847
Two-hybrid Homo sapiens
58 Ddx39 68278
Two-hybrid Mus musculus
59 SUGP1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
60 Rbm38  
Two-hybrid Mus musculus
61 AHCYL1 10768
Co-fractionation Homo sapiens
62 CD2BP2 10421
Affinity Capture-MS Homo sapiens
63 CUL3 8452
Affinity Capture-MS Homo sapiens
64 POLR2D  
Affinity Capture-MS Homo sapiens
65 TST 7263
Co-fractionation Homo sapiens
66 EEF1B2 1933
Co-fractionation Homo sapiens
67 ZC3H11A  
Affinity Capture-MS Homo sapiens
68 SLTM 79811
Affinity Capture-MS Homo sapiens
69 FN1 2335
Affinity Capture-MS Homo sapiens
70 MECP2 4204
Affinity Capture-MS Homo sapiens
71 STRAP 11171
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
72 PPHLN1  
Affinity Capture-MS Homo sapiens
73 GEMIN4 50628
Affinity Capture-MS Homo sapiens
74 PCBP1 5093
Two-hybrid Homo sapiens
75 MFAP1  
Affinity Capture-MS Homo sapiens
76 RPA3 6119
Proximity Label-MS Homo sapiens
77 SUPT16H 11198
Affinity Capture-MS Homo sapiens
78 GNL3 26354
Cross-Linking-MS (XL-MS) Homo sapiens
79 PAXBP1  
Affinity Capture-MS Homo sapiens
80 POLR2J  
Affinity Capture-MS Homo sapiens
81 CTR9 9646
Affinity Capture-MS Homo sapiens
82 BCAS2 10286
Affinity Capture-MS Homo sapiens
83 CHTOP  
Affinity Capture-MS Homo sapiens
84 RBM25 58517
Affinity Capture-MS Homo sapiens
85 ZMAT2  
Affinity Capture-MS Homo sapiens
86 SRSF9 8683
Affinity Capture-MS Homo sapiens
87 YARS 8565
Co-fractionation Homo sapiens
88 PUF60 22827
Two-hybrid Homo sapiens
89 TCERG1 10915
Affinity Capture-MS Homo sapiens
90 CPSF2 53981
Affinity Capture-MS Homo sapiens
91 DYNC1H1 1778
Co-fractionation Homo sapiens
92 LARP7 51574
Affinity Capture-MS Homo sapiens
93 NDUFAF3 25915
Two-hybrid Homo sapiens
94 IK 3550
Affinity Capture-MS Homo sapiens
95 ALYREF 10189
Affinity Capture-MS Homo sapiens
96 HNRNPL 3191
Affinity Capture-MS Homo sapiens
97 SUPT6H 6830
Affinity Capture-MS Homo sapiens
98 HNRNPLL 92906
Two-hybrid Homo sapiens
99 FAM50A 9130
Cross-Linking-MS (XL-MS) Homo sapiens
100 PRPF4 9128
Affinity Capture-MS Homo sapiens
101 SNW1 22938
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
102 CWC22 57703
Affinity Capture-MS Homo sapiens
103 SNRPA1 6627
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
104 LUC7L 55692
Affinity Capture-MS Homo sapiens
105 IFIT2 3433
Affinity Capture-MS Homo sapiens
106 EXOSC8  
Two-hybrid Homo sapiens
107 CCAR1 55749
Affinity Capture-MS Homo sapiens
108 NCBP1 4686
Affinity Capture-MS Homo sapiens
109 RBM22 55696
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
110 ENOX2  
Two-hybrid Homo sapiens
111 QKI 9444
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
112 SF3B1 23451
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
113 ARL6IP4  
Affinity Capture-MS Homo sapiens
114 PCBP2 5094
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
115 Rbm47  
Two-hybrid Mus musculus
116 GEMIN8 54960
Affinity Capture-MS Homo sapiens
117 CAND1 55832
Affinity Capture-MS Homo sapiens
118 SRSF2 6427
Co-fractionation Homo sapiens
119 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 SAFB 6294
Affinity Capture-MS Homo sapiens
121 MRPS10 55173
Affinity Capture-MS Homo sapiens
122 RNPS1 10921
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 RBM3 5935
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
124 SUPT4H1  
Affinity Capture-MS Homo sapiens
125 PRC1 9055
Affinity Capture-MS Homo sapiens
126 MRPS23 51649
Affinity Capture-MS Homo sapiens
127 SRRM2 23524
Affinity Capture-MS Homo sapiens
128 KHDRBS1 10657
Affinity Capture-MS Homo sapiens
129 MAPK14 1432
Affinity Capture-MS Homo sapiens
130 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 RSRC1  
Affinity Capture-MS Homo sapiens
132 CPLX1 10815
Co-fractionation Homo sapiens
133 TIAL1 7073
Affinity Capture-MS Homo sapiens
134 CUL1 8454
Affinity Capture-MS Homo sapiens
135 RBM42  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
136 PRNP 5621
Affinity Capture-MS Homo sapiens
137 LSM2 57819
Affinity Capture-MS Homo sapiens
138 SYMPK 8189
Affinity Capture-MS Homo sapiens
139 HNRNPA0 10949
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
140 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
141 DDX21 9188
Affinity Capture-MS Homo sapiens
142 ZNF207 7756
Affinity Capture-MS Homo sapiens
143 RBM6 10180
Affinity Capture-MS Homo sapiens
144 PEG10 23089
Two-hybrid Homo sapiens
145 TRA2A 29896
Affinity Capture-MS Homo sapiens
146 MAPK7  
Affinity Capture-MS Homo sapiens
147 ACIN1 22985
Affinity Capture-MS Homo sapiens
148 TRIM24  
Co-fractionation Homo sapiens
149 SNRNP200 23020
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
150 IWS1  
Affinity Capture-MS Homo sapiens
151 SNIP1  
Affinity Capture-MS Homo sapiens
152 SNRPD1 6632
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
153 RAD18  
Affinity Capture-MS Homo sapiens
154 TOX4  
Affinity Capture-MS Homo sapiens
155 SCAF11  
Affinity Capture-MS Homo sapiens
156 LYAR 55646
Two-hybrid Homo sapiens
157 MAGOH 4116
Affinity Capture-MS Homo sapiens
158 TXNL4A 10907
Affinity Capture-MS Homo sapiens
159 SNRPB2 6629
Negative Genetic Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
160 ZCCHC8 55596
Affinity Capture-MS Homo sapiens
161 HNRNPD 3184
Affinity Capture-MS Homo sapiens
162 LEO1 123169
Affinity Capture-MS Homo sapiens
163 XPO1 7514
Affinity Capture-MS Homo sapiens
164 RC3H2  
Affinity Capture-MS Homo sapiens
165 KIN  
Affinity Capture-MS Homo sapiens
166 POLR2E 5434
Affinity Capture-MS Homo sapiens
167 WDR33 55339
Affinity Capture-MS Homo sapiens
168 SETD2  
Affinity Capture-MS Homo sapiens
169 YLPM1 56252
Affinity Capture-MS Homo sapiens
170 FUS 2521
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 EFTUD2 9343
Affinity Capture-MS Homo sapiens
172 CDK2 1017
Affinity Capture-MS Homo sapiens
173 TADA2A  
Affinity Capture-MS Homo sapiens
174 MYC  
Affinity Capture-MS Homo sapiens
175 ARHGEF5  
Affinity Capture-MS Homo sapiens
176 CRTAP 10491
Affinity Capture-MS Homo sapiens
177 SART3 9733
Affinity Capture-MS Homo sapiens
178 CUL7 9820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 DDRGK1 65992
Affinity Capture-MS Homo sapiens
180 Pef1  
Two-hybrid Mus musculus
181 ADAR 103
Affinity Capture-MS Homo sapiens
182 Kif3a  
Two-hybrid Mus musculus
183 NKAP 79576
Affinity Capture-MS Homo sapiens
184 RBM8A 9939
Affinity Capture-MS Homo sapiens
185 TERF2  
Affinity Capture-MS Homo sapiens
186 TOE1 114034
Affinity Capture-MS Homo sapiens
187 DIDO1  
Affinity Capture-MS Homo sapiens
188 ILF3 3609
Affinity Capture-MS Homo sapiens
189 FOLR1 2348
Affinity Capture-MS Homo sapiens
190 U2af2 22185
Two-hybrid Mus musculus
191 SF3B4 10262
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
192 PHF3  
Affinity Capture-MS Homo sapiens
193 DMRTB1  
Two-hybrid Homo sapiens
194 AGMAT  
Co-fractionation Homo sapiens
195 PTBP1 5725
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
196 MRPS15  
Affinity Capture-MS Homo sapiens
197 PTBP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
198 HNRNPK 3190
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
199 YTHDF3  
Two-hybrid Homo sapiens
200 DDX39A 10212
Affinity Capture-MS Homo sapiens
201 DDX42 11325
Affinity Capture-MS Homo sapiens
202 CDKN2A 1029
Reconstituted Complex Homo sapiens
203 ARHGAP23 57636
Affinity Capture-MS Homo sapiens
204 IFIT1 3434
Affinity Capture-MS Homo sapiens
205 Srsf3 20383
Two-hybrid Mus musculus
206 PRMT1 3276
Affinity Capture-MS Homo sapiens
207 TIMM13 26517
Co-fractionation Homo sapiens
208 ZNF830  
Affinity Capture-MS Homo sapiens
209 RALY 22913
Affinity Capture-MS Homo sapiens
210 NUPL2 11097
Affinity Capture-MS Homo sapiens
211 Mrpl13  
Two-hybrid Mus musculus
212 GTF2F1 2962
Co-fractionation Homo sapiens
213 HNRNPC 3183
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
214 KHDRBS3  
Affinity Capture-MS Homo sapiens
215 SNRPG 6637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
216 SNRPE 6635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
217 TGS1  
Affinity Capture-MS Homo sapiens
218 HNRNPR 10236
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
219 PPP1R10