Gene description for TST
Gene name thiosulfate sulfurtransferase (rhodanese)
Gene symbol TST
Other names/aliases RDS
Species Homo sapiens
 Database cross references - TST
ExoCarta ExoCarta_7263
Entrez Gene 7263
HGNC 12388
MIM 180370
UniProt Q16762  
 TST identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for TST
Molecular Function
    5S rRNA binding GO:0008097 IDA
    thiosulfate sulfurtransferase activity GO:0004792 IEA
Biological Process
    sulfide oxidation, using sulfide:quinone oxidoreductase GO:0070221 TAS
    rRNA import into mitochondrion GO:0035928 IMP
    sulfur amino acid catabolic process GO:0000098 TAS
    small molecule metabolic process GO:0044281 TAS
    epithelial cell differentiation GO:0030855 IDA
    cyanate catabolic process GO:0009440 TAS
    rRNA transport GO:0051029 IDA
    sulfur amino acid metabolic process GO:0000096 TAS
    cellular nitrogen compound metabolic process GO:0034641 TAS
Subcellular Localization
    extracellular space GO:0005615 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IEA
    mitochondrial inner membrane GO:0005743 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified TST in exosomes
1
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for TST
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRSS1  
Invitro Homo sapiens
2 ND1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which TST is involved
PathwayEvidenceSource
Sulfide oxidation to sulfate TAS Reactome





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