Gene description for LARS2
Gene name leucyl-tRNA synthetase 2, mitochondrial
Gene symbol LARS2
Other names/aliases LEURS
PRLTS4
Species Homo sapiens
 Database cross references - LARS2
ExoCarta ExoCarta_23395
Vesiclepedia VP_23395
Entrez Gene 23395
HGNC 17095
MIM 604544
UniProt Q15031  
 LARS2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LARS2
Molecular Function
    aminoacyl-tRNA editing activity GO:0002161 IEA
    leucine-tRNA ligase activity GO:0004823 IBA
    leucine-tRNA ligase activity GO:0004823 IDA
    leucine-tRNA ligase activity GO:0004823 TAS
    ATP binding GO:0005524 IEA
Biological Process
    tRNA aminoacylation for protein translation GO:0006418 TAS
    leucyl-tRNA aminoacylation GO:0006429 IBA
    leucyl-tRNA aminoacylation GO:0006429 IDA
    mitochondrial translation GO:0032543 IBA
    aminoacyl-tRNA metabolism involved in translational fidelity GO:0106074 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified LARS2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LARS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGOLN2 10618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
4 HCST  
Affinity Capture-MS Homo sapiens
5 RPA2 6118
Proximity Label-MS Homo sapiens
6 SUCLG1 8802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MTG2  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 UQCRB 7381
Affinity Capture-MS Homo sapiens
9 GPR182  
Affinity Capture-MS Homo sapiens
10 BPNT1 10380
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RPUSD4 84881
Proximity Label-MS Homo sapiens
12 MTRF1  
Proximity Label-MS Homo sapiens
13 GFM2 84340
Proximity Label-MS Homo sapiens
14 MRPS24 64951
Affinity Capture-MS Homo sapiens
15 CCDC90B  
Proximity Label-MS Homo sapiens
16 LRPPRC 10128
Proximity Label-MS Homo sapiens
17 ATP5D 513
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RDX 5962
Affinity Capture-MS Homo sapiens
19 SSC4D  
Affinity Capture-MS Homo sapiens
20 CRYZ 1429
Proximity Label-MS Homo sapiens
21 TRMU  
Affinity Capture-MS Homo sapiens
22 RAMP2  
Affinity Capture-MS Homo sapiens
23 PMPCA 23203
Proximity Label-MS Homo sapiens
24 SDHB 6390
Affinity Capture-MS Homo sapiens
25 NIT1 4817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 YARS2  
Affinity Capture-MS Homo sapiens
27 HINT2 84681
Proximity Label-MS Homo sapiens
28 COQ3  
Affinity Capture-MS Homo sapiens
29 GLMP 112770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GCAT  
Affinity Capture-MS Homo sapiens
31 FTSJ2 29960
Affinity Capture-MS Homo sapiens
32 MRPS26 64949
Proximity Label-MS Homo sapiens
33 MALSU1  
Affinity Capture-MS Homo sapiens
34 PTCD1 26024
Affinity Capture-MS Homo sapiens
35 EXD2  
Proximity Label-MS Homo sapiens
36 NAA38  
Affinity Capture-MS Homo sapiens
37 MRPS7 51081
Affinity Capture-MS Homo sapiens
38 WIF1 11197
Affinity Capture-MS Homo sapiens
39 PMPCB 9512
Proximity Label-MS Homo sapiens
40 TACO1  
Proximity Label-MS Homo sapiens
41 VWA8 23078
Proximity Label-MS Homo sapiens
42 MTERF3  
Proximity Label-MS Homo sapiens
43 MDH2 4191
Proximity Label-MS Homo sapiens
44 TAZ  
Affinity Capture-MS Homo sapiens
45 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 C6orf203  
Proximity Label-MS Homo sapiens
47 ACSM5 54988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 FASTKD5  
Proximity Label-MS Homo sapiens
49 PARK2  
Affinity Capture-MS Homo sapiens
50 SURF1  
Proximity Label-MS Homo sapiens
51 AMACR 23600
Affinity Capture-MS Homo sapiens
52 TUFM 7284
Proximity Label-MS Homo sapiens
53 BCL2L12 83596
Affinity Capture-MS Homo sapiens
54 CCDC109B 55013
Proximity Label-MS Homo sapiens
55 TBRG4 9238
Proximity Label-MS Homo sapiens
56 YWHAQ 10971
Reconstituted Complex Homo sapiens
57 TRUB2  
Proximity Label-MS Homo sapiens
58 MRPL11 65003
Proximity Label-MS Homo sapiens
59 MTRF1L  
Proximity Label-MS Homo sapiens
60 RASL10B  
Affinity Capture-MS Homo sapiens
61 HSD17B8  
Affinity Capture-MS Homo sapiens
62 COX4I1 1327
Proximity Label-MS Homo sapiens
63 KDF1  
Affinity Capture-MS Homo sapiens
64 DUSP22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 MRM1  
Affinity Capture-MS Homo sapiens
66 NTRK1 4914
Affinity Capture-MS Homo sapiens
67 OTC 5009
Proximity Label-MS Homo sapiens
68 RHOU 58480
Reconstituted Complex Homo sapiens
69 MRPL21 219927
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 MRRF  
Proximity Label-MS Homo sapiens
71 MRPS12  
Proximity Label-MS Homo sapiens
72 MTIF2 4528
Proximity Label-MS Homo sapiens
73 BCKDHB 594
Affinity Capture-MS Homo sapiens
74 MTIF3  
Proximity Label-MS Homo sapiens
75 NPTN 27020
Affinity Capture-MS Homo sapiens
76 MEX3A  
Affinity Capture-RNA Homo sapiens
77 METTL20  
Affinity Capture-MS Homo sapiens
78 SYT6  
Affinity Capture-MS Homo sapiens
79 RMND1 55005
Proximity Label-MS Homo sapiens
80 FAHD1 81889
Affinity Capture-MS Homo sapiens
81 TST 7263
Co-fractionation Homo sapiens
82 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
83 C12orf65  
Proximity Label-MS Homo sapiens
84 RPA3 6119
Proximity Label-MS Homo sapiens
85 GPR45  
Affinity Capture-MS Homo sapiens
86 CBR4  
Affinity Capture-MS Homo sapiens
87 ACAD9 28976
Proximity Label-MS Homo sapiens
88 NDUFA10 4705
Affinity Capture-MS Homo sapiens
89 ISLR 3671
Affinity Capture-MS Homo sapiens
90 MRPS17 51373
Affinity Capture-MS Homo sapiens
91 PDP1 54704
Affinity Capture-MS Homo sapiens
92 PFDN5 5204
Affinity Capture-MS Homo sapiens
93 MCUR1 63933
Proximity Label-MS Homo sapiens
94 AK4 205
Affinity Capture-MS Homo sapiens
95 CLPP 8192
Proximity Label-MS Homo sapiens
96 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
97 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
98 FBXW11  
Affinity Capture-MS Homo sapiens
99 TSFM 10102
Proximity Label-MS Homo sapiens
100 AUH 549
Proximity Label-MS Homo sapiens
101 LIG3 3980
Affinity Capture-MS Homo sapiens
102 MRPS2 51116
Affinity Capture-MS Homo sapiens
103 ICT1 3396
Proximity Label-MS Homo sapiens
104 ABHD10 55347
Affinity Capture-MS Homo sapiens
105 ACAA2 10449
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 PDHA1 5160
Proximity Label-MS Homo sapiens
107 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 COX8A  
Proximity Label-MS Homo sapiens
109 C21orf33  
Proximity Label-MS Homo sapiens
110 SSBP1 6742
Proximity Label-MS Homo sapiens
111 MRPS30 10884
Affinity Capture-MS Homo sapiens
112 FASTKD3  
Proximity Label-MS Homo sapiens
113 GFM1 85476
Proximity Label-MS Homo sapiens
114 AARS2  
Proximity Label-MS Homo sapiens
115 PCCB 5096
Affinity Capture-MS Homo sapiens
116 RPUSD3  
Proximity Label-MS Homo sapiens
117 MYL10 93408
Affinity Capture-MS Homo sapiens
118 GRSF1 2926
Proximity Label-MS Homo sapiens
119 C1QBP 708
Proximity Label-MS Homo sapiens
120 KRAS 3845
Negative Genetic Homo sapiens
121 METTL17  
Proximity Label-MS Homo sapiens
122 YBEY  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 C8orf82  
Proximity Label-MS Homo sapiens
124 TRIM43  
Affinity Capture-MS Homo sapiens
125 TIMM13 26517
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which LARS2 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Mitochondrial tRNA aminoacylation TAS Reactome
Translation TAS Reactome
tRNA Aminoacylation TAS Reactome





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