Gene description for LARS2
Gene name leucyl-tRNA synthetase 2, mitochondrial
Gene symbol LARS2
Other names/aliases LEURS
PRLTS4
Species Homo sapiens
 Database cross references - LARS2
ExoCarta ExoCarta_23395
Vesiclepedia VP_23395
Entrez Gene 23395
HGNC 17095
MIM 604544
UniProt Q15031  
 LARS2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LARS2
Molecular Function
    aminoacyl-tRNA editing activity GO:0002161 IEA
    ATP binding GO:0005524 IEA
    leucine-tRNA ligase activity GO:0004823 IBA
Biological Process
    regulation of translational fidelity GO:0006450 IEA
    gene expression GO:0010467 TAS
    tRNA aminoacylation for protein translation GO:0006418 TAS
    leucyl-tRNA aminoacylation GO:0006429 IBA
Subcellular Localization
    mitochondrion GO:0005739 IBA
    cytosol GO:0005829 IBA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified LARS2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LARS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LARS2 is involved
PathwayEvidenceSource
Mitochondrial tRNA aminoacylation TAS Reactome





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