Gene description for AK4
Gene name adenylate kinase 4
Gene symbol AK4
Other names/aliases AK 4
AK3
AK3L1
AK3L2
Species Homo sapiens
 Database cross references - AK4
ExoCarta ExoCarta_205
Entrez Gene 205
HGNC 363
MIM 103030
UniProt P27144  
 AK4 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for AK4
Molecular Function
    nucleoside diphosphate kinase activity GO:0004550 IDA
    adenylate kinase activity GO:0004017 IDA
    GTP binding GO:0005525 IEA
    nucleoside triphosphate adenylate kinase activity GO:0046899 IDA
    ATP binding GO:0005524 IEA
Biological Process
    GTP metabolic process GO:0046039 IDA
    ATP metabolic process GO:0046034 IDA
    brain development GO:0007420 IEA
    nucleoside triphosphate biosynthetic process GO:0009142 IDA
    response to drug GO:0042493 IEA
    ADP biosynthetic process GO:0006172 IEA
    nucleoside diphosphate phosphorylation GO:0006165 IDA
    liver development GO:0001889 IEA
    AMP metabolic process GO:0046033 IDA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 ISS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified AK4 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AK4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AK4 is involved
No pathways found





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