Gene description for FECH
Gene name ferrochelatase
Gene symbol FECH
Other names/aliases EPP
FCE
Species Homo sapiens
 Database cross references - FECH
ExoCarta ExoCarta_2235
Vesiclepedia VP_2235
Entrez Gene 2235
HGNC 3647
MIM 612386
UniProt P22830  
 FECH identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FECH
Molecular Function
    ferrous iron binding GO:0008198 TAS
    2 iron, 2 sulfur cluster binding GO:0051537 IEA
    protein binding GO:0005515 IPI
    iron-responsive element binding GO:0030350 IEA
    ferrochelatase activity GO:0004325 TAS
    heme binding GO:0020037 IEA
Biological Process
    response to methylmercury GO:0051597 IEA
    generation of precursor metabolites and energy GO:0006091 TAS
    regulation of eIF2 alpha phosphorylation by heme GO:0010999 IEA
    response to arsenic-containing substance GO:0046685 IEA
    response to platinum ion GO:0070541 IEA
    heme biosynthetic process GO:0006783 TAS
    very-low-density lipoprotein particle assembly GO:0034379 IEA
    regulation of hemoglobin biosynthetic process GO:0046984 IEA
    small molecule metabolic process GO:0044281 TAS
    protoporphyrinogen IX metabolic process GO:0046501 IDA
    response to insecticide GO:0017085 IEA
    cellular response to dexamethasone stimulus GO:0071549 IEA
    response to ethanol GO:0045471 IEA
    response to lead ion GO:0010288 IEA
    regulation of gene expression GO:0010468 IEA
    detection of UV GO:0009589 IEA
    iron ion homeostasis GO:0055072 IEA
    response to drug GO:0042493 IEA
    cholesterol metabolic process GO:0008203 IEA
    porphyrin-containing compound metabolic process GO:0006778 TAS
    erythrocyte differentiation GO:0030218 IEA
    response to light stimulus GO:0009416 TAS
Subcellular Localization
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 TAS
    mitochondrial inner membrane GO:0005743 IEA
 Experiment description of studies that identified FECH in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FECH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FECH 2235
Invivo Homo sapiens
Invivo Homo sapiens
2 ABCB7 22
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which FECH is involved
PathwayEvidenceSource
Heme biosynthesis TAS Reactome





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