Gene description for ABCB7
Gene name ATP-binding cassette, sub-family B (MDR/TAP), member 7
Gene symbol ABCB7
Other names/aliases ABC7
ASAT
Atm1p
EST140535
Species Homo sapiens
 Database cross references - ABCB7
ExoCarta ExoCarta_22
Vesiclepedia VP_22
Entrez Gene 22
HGNC 48
MIM 300135
UniProt O75027  
 ABCB7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ABCB7
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    heme transmembrane transporter activity GO:0015232 TAS
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    ABC-type iron-sulfur cluster transporter activity GO:0140481 IMP
Biological Process
    intracellular iron ion homeostasis GO:0006879 IBA
    intracellular iron ion homeostasis GO:0006879 IMP
    intracellular iron ion homeostasis GO:0006879 ISS
    heme transport GO:0015886 IEA
    iron-sulfur cluster assembly GO:0016226 ISS
    iron ion transmembrane transport GO:0034755 IDA
    transmembrane transport GO:0055085 IBA
    positive regulation of heme biosynthetic process GO:0070455 IMP
    positive regulation of heme biosynthetic process GO:0070455 ISS
    iron-sulfur cluster export from the mitochondrion GO:0140466 IMP
    positive regulation of iron-sulfur cluster assembly GO:1903331 IMP
    positive regulation of iron-sulfur cluster assembly GO:1903331 ISS
    negative regulation of reactive oxygen species biosynthetic process GO:1903427 ISS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified ABCB7 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ABCB7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 PDCD6 10016
Co-fractionation Homo sapiens
3 RAMP3  
Affinity Capture-MS Homo sapiens
4 MTCH1 23787
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
5 COQ9  
Affinity Capture-MS Homo sapiens
6 RPA2 6118
Proximity Label-MS Homo sapiens
7 PDCD1  
Affinity Capture-MS Homo sapiens
8 TRUB2  
Proximity Label-MS Homo sapiens
9 MTG2  
Proximity Label-MS Homo sapiens
10 C9orf78 51759
Affinity Capture-MS Homo sapiens
11 MRPL10 124995
Co-fractionation Homo sapiens
12 UBC 7316
Reconstituted Complex Homo sapiens
13 VSTM1  
Affinity Capture-MS Homo sapiens
14 KLRB1  
Affinity Capture-MS Homo sapiens
15 NDUFA4 4697
Affinity Capture-MS Homo sapiens
16 DNAJC15  
Proximity Label-MS Homo sapiens
17 MTRF1  
Proximity Label-MS Homo sapiens
18 APP 351
Reconstituted Complex Homo sapiens
19 CCDC90B  
Proximity Label-MS Homo sapiens
20 APEX1 328
Affinity Capture-RNA Homo sapiens
21 KIAA1429 25962
Affinity Capture-MS Homo sapiens
22 Kcnk1  
Affinity Capture-MS Mus musculus
23 MCU 90550
Proximity Label-MS Homo sapiens
24 PMPCA 23203
Proximity Label-MS Homo sapiens
25 PCK1 5105
Affinity Capture-MS Homo sapiens
26 HLA-B 3106
Affinity Capture-MS Homo sapiens
27 HINT2 84681
Proximity Label-MS Homo sapiens
28 SURF1  
Proximity Label-MS Homo sapiens
29 PMPCB 9512
Proximity Label-MS Homo sapiens
30 TACO1  
Proximity Label-MS Homo sapiens
31 FAF2 23197
Affinity Capture-MS Homo sapiens
32 CKM  
Co-fractionation Homo sapiens
33 MDH2 4191
Proximity Label-MS Homo sapiens
34 TUFM 7284
Proximity Label-MS Homo sapiens
35 UNK  
Affinity Capture-RNA Homo sapiens
36 MTCH2 23788
Proximity Label-MS Homo sapiens
37 C6orf203  
Proximity Label-MS Homo sapiens
38 COX15 1355
Proximity Label-MS Homo sapiens
39 CTDP1 9150
Affinity Capture-MS Homo sapiens
40 PARK2  
Affinity Capture-MS Homo sapiens
41 VSIG4  
Affinity Capture-MS Homo sapiens
42 C12orf49  
Negative Genetic Homo sapiens
43 NTRK1 4914
Affinity Capture-MS Homo sapiens
44 CCDC109B 55013
Proximity Label-MS Homo sapiens
45 GFM1 85476
Proximity Label-MS Homo sapiens
46 UQCRC1 7384
Co-fractionation Homo sapiens
47 RPN1 6184
Co-fractionation Homo sapiens
48 MRPL11 65003
Proximity Label-MS Homo sapiens
49 MTRF1L  
Proximity Label-MS Homo sapiens
50 SDF4 51150
Affinity Capture-MS Homo sapiens
51 TMEM70  
Proximity Label-MS Homo sapiens
52 FOXS1  
Affinity Capture-MS Homo sapiens
53 MAT2A 4144
Co-fractionation Homo sapiens
54 ACAT1 38
Co-fractionation Homo sapiens
55 AIFM1 9131
Proximity Label-MS Homo sapiens
56 MTIF2 4528
Proximity Label-MS Homo sapiens
57 EGLN3  
Affinity Capture-MS Homo sapiens
58 FECH 2235
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
59 ATP6V1D 51382
Co-fractionation Homo sapiens
60 MGARP  
Affinity Capture-MS Homo sapiens
61 CUL3 8452
Affinity Capture-MS Homo sapiens
62 EGFR 1956
Negative Genetic Homo sapiens
63 FKBP8 23770
Co-fractionation Homo sapiens
64 HOOK3 84376
Proximity Label-MS Homo sapiens
65 KLRG2 346689
Affinity Capture-MS Homo sapiens
66 AQP3  
Affinity Capture-MS Homo sapiens
67 EPRS 2058
Co-fractionation Homo sapiens
68 OCIAD1 54940
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 C17orf80 55028
Proximity Label-MS Homo sapiens
70 C12orf65  
Proximity Label-MS Homo sapiens
71 TSPAN8 7103
Affinity Capture-MS Homo sapiens
72 RPA3 6119
Proximity Label-MS Homo sapiens
73 GPR45  
Affinity Capture-MS Homo sapiens
74 NDUFB6 4712
Co-fractionation Homo sapiens
75 ACAD9 28976
Proximity Label-MS Homo sapiens
76 AKAP1 8165
Proximity Label-MS Homo sapiens
77 MCUR1 63933
Proximity Label-MS Homo sapiens
78 CLPP 8192
Proximity Label-MS Homo sapiens
79 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
80 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
81 TSFM 10102
Proximity Label-MS Homo sapiens
82 AUH 549
Proximity Label-MS Homo sapiens
83 LRPPRC 10128
Proximity Label-MS Homo sapiens
84 DNAJC19 131118
Proximity Label-MS Homo sapiens
85 OPALIN  
Affinity Capture-MS Homo sapiens
86 ICT1 3396
Affinity Capture-MS Homo sapiens
87 MFSD4  
Affinity Capture-MS Homo sapiens
88 LONP1 9361
Proximity Label-MS Homo sapiens
89 CKB 1152
Co-fractionation Homo sapiens
90 CLEC2D  
Affinity Capture-MS Homo sapiens
91 PDHA1 5160
Proximity Label-MS Homo sapiens
92 DNAJA3 9093
Proximity Label-MS Homo sapiens
93 COX8A  
Proximity Label-MS Homo sapiens
94 C21orf33  
Proximity Label-MS Homo sapiens
95 SSBP1 6742
Proximity Label-MS Homo sapiens
96 TBRG4 9238
Proximity Label-MS Homo sapiens
97 AARS2  
Proximity Label-MS Homo sapiens
98 YBX3 8531
Co-fractionation Homo sapiens
99 SLC25A51  
Proximity Label-MS Homo sapiens
100 C1QBP 708
Proximity Label-MS Homo sapiens
101 SERBP1 26135
Affinity Capture-MS Homo sapiens
102 KRAS 3845
Negative Genetic Homo sapiens
103 C9orf72  
Affinity Capture-MS Homo sapiens
104 METTL17  
Proximity Label-MS Homo sapiens
105 RAB2A 5862
Co-fractionation Homo sapiens
View the network image/svg+xml



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