Gene description for C9orf78
Gene name chromosome 9 open reading frame 78
Gene symbol C9orf78
Other names/aliases HCA59
HSPC220
bA409K20.3
Species Homo sapiens
 Database cross references - C9orf78
ExoCarta ExoCarta_51759
Vesiclepedia VP_51759
Entrez Gene 51759
HGNC 24932
UniProt Q9NZ63  
 C9orf78 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for C9orf78
Molecular Function
    protein binding GO:0005515 IPI
    U5 snRNA binding GO:0030623 IDA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IBA
    chromosome segregation GO:0007059 IEA
    mRNA cis splicing, via spliceosome GO:0045292 IMP
    regulation of homologous chromosome segregation GO:0060629 IMP
Subcellular Localization
    chromosome, centromeric region GO:0000775 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified C9orf78 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for C9orf78
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC25A13 10165
Affinity Capture-MS Homo sapiens
2 NPEPPS 9520
Affinity Capture-MS Homo sapiens
3 PQBP1  
Affinity Capture-MS Homo sapiens
4 WDR6 11180
Affinity Capture-MS Homo sapiens
5 HOOK1  
Affinity Capture-MS Homo sapiens
6 ARHGEF19  
Affinity Capture-MS Homo sapiens
7 ZMYND8 23613
Affinity Capture-MS Homo sapiens
8 MED17  
Affinity Capture-MS Homo sapiens
9 SKIV2L 6499
Affinity Capture-MS Homo sapiens
10 KPNA1 3836
Affinity Capture-MS Homo sapiens
11 PKP2 5318
Affinity Capture-MS Homo sapiens
12 DYNC1I2 1781
Affinity Capture-MS Homo sapiens
13 SERPINB13 5275
Affinity Capture-MS Homo sapiens
14 VPS35 55737
Affinity Capture-MS Homo sapiens
15 MAP4 4134
Affinity Capture-MS Homo sapiens
16 C9orf78 51759
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CSE1L 1434
Affinity Capture-MS Homo sapiens
18 ELP2 55250
Affinity Capture-MS Homo sapiens
19 SCAF4 57466
Affinity Capture-MS Homo sapiens
20 MSI1  
Affinity Capture-MS Homo sapiens
21 TCEB3 6924
Affinity Capture-MS Homo sapiens
22 KBTBD6  
Affinity Capture-MS Homo sapiens
23 DDX23 9416
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 BTBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 MEAF6  
Affinity Capture-MS Homo sapiens
26 MON2 23041
Affinity Capture-MS Homo sapiens
27 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
28 MATR3 9782
Affinity Capture-MS Homo sapiens
29 USP39 10713
Affinity Capture-MS Homo sapiens
30 H2AFV 94239
Co-fractionation Homo sapiens
31 HDAC2 3066
Affinity Capture-MS Homo sapiens
32 SEL1L 6400
Affinity Capture-MS Homo sapiens
33 HSPH1 10808
Affinity Capture-MS Homo sapiens
34 ABCD3 5825
Affinity Capture-MS Homo sapiens
35 ABI1 10006
Affinity Capture-MS Homo sapiens
36 AGK 55750
Affinity Capture-MS Homo sapiens
37 MAGED2 10916
Affinity Capture-MS Homo sapiens
38 ACSL1 2180
Affinity Capture-MS Homo sapiens
39 BCS1L 617
Affinity Capture-MS Homo sapiens
40 PPP6R3 55291
Affinity Capture-MS Homo sapiens
41 GPS1 2873
Affinity Capture-MS Homo sapiens
42 NDUFS1 4719
Affinity Capture-MS Homo sapiens
43 GNPAT 8443
Affinity Capture-MS Homo sapiens
44 HSPD1 3329
Affinity Capture-MS Homo sapiens
45 SLC25A3 5250
Affinity Capture-MS Homo sapiens
46 EXOC3 11336
Affinity Capture-MS Homo sapiens
47 EXOC4 60412
Affinity Capture-MS Homo sapiens
48 EXOSC9 5393
Affinity Capture-MS Homo sapiens
49 GOLIM4 27333
Affinity Capture-MS Homo sapiens
50 CNOT11 55571
Affinity Capture-MS Homo sapiens
51 RFC5 5985
Affinity Capture-MS Homo sapiens
52 ACOT9 23597
Affinity Capture-MS Homo sapiens
53 VPS51 738
Affinity Capture-MS Homo sapiens
54 ACADVL 37
Affinity Capture-MS Homo sapiens
55 SUPT5H 6829
Affinity Capture-MS Homo sapiens
56 PTCD3 55037
Affinity Capture-MS Homo sapiens
57 CCDC132 55610
Affinity Capture-MS Homo sapiens
58 TUFM 7284
Affinity Capture-MS Homo sapiens
59 COPB1 1315
Affinity Capture-MS Homo sapiens
60 PDXDC1 23042
Affinity Capture-MS Homo sapiens
61 CIRH1A 84916
Affinity Capture-MS Homo sapiens
62 CLCC1 23155
Affinity Capture-MS Homo sapiens
63 PSMD2 5708
Affinity Capture-MS Homo sapiens
64 PDS5A 23244
Affinity Capture-MS Homo sapiens
65 CKAP5 9793
Affinity Capture-MS Homo sapiens
66 PIGT 51604
Affinity Capture-MS Homo sapiens
67 ACADM 34
Affinity Capture-MS Homo sapiens
68 GTF3C2  
Affinity Capture-MS Homo sapiens
69 ANAPC5 51433
Affinity Capture-MS Homo sapiens
70 XPOT 11260
Affinity Capture-MS Homo sapiens
71 ASCC2 84164
Affinity Capture-MS Homo sapiens
72 CYC1 1537
Affinity Capture-MS Homo sapiens
73 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
74 CUL2 8453
Affinity Capture-MS Homo sapiens
75 TRMT2A 27037
Affinity Capture-MS Homo sapiens
76 PICALM 8301
Affinity Capture-MS Homo sapiens
77 IQGAP2 10788
Affinity Capture-MS Homo sapiens
78 CD3EAP  
Proximity Label-MS Homo sapiens
79 HSPA5 3309
Affinity Capture-MS Homo sapiens
80 WDR11 55717
Affinity Capture-MS Homo sapiens
81 HADHB 3032
Affinity Capture-MS Homo sapiens
82 HADHA 3030
Affinity Capture-MS Homo sapiens
83 HBS1L 10767
Affinity Capture-MS Homo sapiens
84 DAP3 7818
Affinity Capture-MS Homo sapiens
85 MCCC2 64087
Affinity Capture-MS Homo sapiens
86 JPH3 57338
Affinity Capture-MS Homo sapiens
87 LRRC59 55379
Affinity Capture-MS Homo sapiens
88 IGHA1 3493
Affinity Capture-MS Homo sapiens
89 CD2BP2 10421
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PON2 5445
Affinity Capture-MS Homo sapiens
91 BCAP31 10134
Affinity Capture-MS Homo sapiens
92 GPD2 2820
Affinity Capture-MS Homo sapiens
93 APMAP 57136
Affinity Capture-MS Homo sapiens
94 PI4K2A 55361
Affinity Capture-MS Homo sapiens
95 ZC3H11A  
Affinity Capture-MS Homo sapiens
96 RBBP4 5928
Affinity Capture-MS Homo sapiens
97 GTF3C4 9329
Affinity Capture-MS Homo sapiens
98 MYO1C 4641
Affinity Capture-MS Homo sapiens
99 SNX9 51429
Affinity Capture-MS Homo sapiens
100 HEXA 3073
Co-fractionation Homo sapiens
101 CYP51A1 1595
Affinity Capture-MS Homo sapiens
102 TRIM32 22954
Affinity Capture-MS Homo sapiens
103 UBA2 10054
Affinity Capture-MS Homo sapiens
104 RPA3 6119
Proximity Label-MS Homo sapiens
105 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
106 FCHSD2  
Two-hybrid Homo sapiens
107 DLST 1743
Affinity Capture-MS Homo sapiens
108 AP2A2 161
Affinity Capture-MS Homo sapiens
109 MBD2 8932
Affinity Capture-MS Homo sapiens
110 FAM21C 253725
Affinity Capture-MS Homo sapiens
111 MED23 9439
Affinity Capture-MS Homo sapiens
112 SPATA5 166378
Affinity Capture-MS Homo sapiens
113 NDUFA3  
Affinity Capture-MS Homo sapiens
114 NDUFA10 4705
Affinity Capture-MS Homo sapiens
115 TMX4 56255
Affinity Capture-MS Homo sapiens
116 HAT1 8520
Affinity Capture-MS Homo sapiens
117 DLAT 1737
Affinity Capture-MS Homo sapiens
118 MED14  
Affinity Capture-MS Homo sapiens
119 SCCPDH 51097
Affinity Capture-MS Homo sapiens
120 ASUN  
Affinity Capture-MS Homo sapiens
121 RAB39A 54734
Affinity Capture-MS Homo sapiens
122 GLS 2744
Affinity Capture-MS Homo sapiens
123 PRDM10  
Affinity Capture-MS Homo sapiens
124 EAPP  
Affinity Capture-MS Homo sapiens
125 IDH3B 3420
Affinity Capture-MS Homo sapiens
126 MTA1 9112
Affinity Capture-MS Homo sapiens
127 TCERG1 10915
Affinity Capture-MS Homo sapiens
128 STRN4 29888
Affinity Capture-MS Homo sapiens
129 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
130 FKBP9 11328
Co-fractionation Homo sapiens
131 TBL3 10607
Affinity Capture-MS Homo sapiens
132 GET4 51608
Affinity Capture-MS Homo sapiens
133 ELMO2 63916
Affinity Capture-MS Homo sapiens
134 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
135 ERCC3  
Affinity Capture-MS Homo sapiens
136 XPO5 57510
Affinity Capture-MS Homo sapiens
137 IK 3550
Affinity Capture-MS Homo sapiens
138 SUPT6H 6830
Affinity Capture-MS Homo sapiens
139 NDC1 55706
Affinity Capture-MS Homo sapiens
140 ATG4B 23192
Affinity Capture-MS Homo sapiens
141 SORT1 6272
Affinity Capture-MS Homo sapiens
142 FECH 2235
Affinity Capture-MS Homo sapiens
143 HEATR3 55027
Affinity Capture-MS Homo sapiens
144 FAM50A 9130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 POLR3B 55703
Affinity Capture-MS Homo sapiens
146 LIMD1 8994
Co-fractionation Homo sapiens
147 PGM3 5238
Affinity Capture-MS Homo sapiens
148 EHMT1  
Affinity Capture-MS Homo sapiens
149 CWC22 57703
Affinity Capture-MS Homo sapiens
150 CNOT10 25904
Affinity Capture-MS Homo sapiens
151 NUP85 79902
Affinity Capture-MS Homo sapiens
152 PSMC4 5704
Affinity Capture-MS Homo sapiens
153 AP5Z1 9907
Affinity Capture-MS Homo sapiens
154 MRPL28 10573
Affinity Capture-MS Homo sapiens
155 PCYT1A 5130
Affinity Capture-MS Homo sapiens
156 RANGAP1 5905
Affinity Capture-MS Homo sapiens
157 PSMD3 5709
Affinity Capture-MS Homo sapiens
158 IFT74 80173
Affinity Capture-MS Homo sapiens
159 HNRNPH1 3187
Co-fractionation Homo sapiens
160 H2AFJ 55766
Affinity Capture-MS Homo sapiens
161 PRKAA1 5562
Affinity Capture-MS Homo sapiens
162 YKT6 10652
Affinity Capture-MS Homo sapiens
163 EXOC1 55763
Affinity Capture-MS Homo sapiens
164 GTF3C5 9328
Affinity Capture-MS Homo sapiens
165 LENG8  
Affinity Capture-MS Homo sapiens
166 CEP170 9859
Affinity Capture-MS Homo sapiens
167 NUP62 23636
Affinity Capture-MS Homo sapiens
168 AP2A1 160
Affinity Capture-MS Homo sapiens
169 SRPR 6734
Affinity Capture-MS Homo sapiens
170 TRIM33 51592
Affinity Capture-MS Homo sapiens
171 NUP50 10762
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
173 TERF2IP 54386
Two-hybrid Homo sapiens
174 AAR2 25980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 CLUH 23277
Affinity Capture-MS Homo sapiens
176 ARID3B  
Affinity Capture-MS Homo sapiens
177 COPA 1314
Affinity Capture-MS Homo sapiens
178 PWP2 5822
Affinity Capture-MS Homo sapiens
179 NDUFS2 4720
Affinity Capture-MS Homo sapiens
180 NUP160 23279
Affinity Capture-MS Homo sapiens
181 KIAA1598 57698
Affinity Capture-MS Homo sapiens
182 NCOR1  
Affinity Capture-MS Homo sapiens
183 DIAPH1 1729
Affinity Capture-MS Homo sapiens
184 WDR41  
Affinity Capture-MS Homo sapiens
185 USO1 8615
Affinity Capture-MS Homo sapiens
186 LRRC1 55227
Affinity Capture-MS Homo sapiens
187 DPYSL2 1808
Affinity Capture-MS Homo sapiens
188 DDX24 57062
Affinity Capture-MS Homo sapiens
189 COPS6 10980
Affinity Capture-MS Homo sapiens
190 DHX35  
Affinity Capture-MS Homo sapiens
191 EXOC2 55770
Affinity Capture-MS Homo sapiens
192 NR2F2  
Affinity Capture-MS Homo sapiens
193 AP1G1 164
Affinity Capture-MS Homo sapiens
194 IPO5 3843
Affinity Capture-MS Homo sapiens
195 NUP93 9688
Affinity Capture-MS Homo sapiens
196 STAT3 6774
Affinity Capture-MS Homo sapiens
197 TBC1D15 64786
Affinity Capture-MS Homo sapiens
198 LEO1 123169
Affinity Capture-MS Homo sapiens
199 TOMM40 10452
Affinity Capture-MS Homo sapiens
200 SERF2 10169
Affinity Capture-MS Homo sapiens
201 TRIM25 7706
Co-fractionation Homo sapiens
202 CTPS1 1503
Affinity Capture-MS Homo sapiens
203 CUL1 8454
Affinity Capture-MS Homo sapiens
204 TIMM50 92609
Affinity Capture-MS Homo sapiens
205 RBM42  
Affinity Capture-MS Homo sapiens
206 EXOC7 23265
Affinity Capture-MS Homo sapiens
207 HK1 3098
Affinity Capture-MS Homo sapiens
208 PCYOX1 51449
Affinity Capture-MS Homo sapiens
209 SMC2 10592
Affinity Capture-MS Homo sapiens
210 GTF2I 2969
Affinity Capture-MS Homo sapiens
211 NNT 23530
Affinity Capture-MS Homo sapiens
212 PFKM 5213
Affinity Capture-MS Homo sapiens
213 TTC37 9652
Affinity Capture-MS Homo sapiens
214 IPO11 51194
Affinity Capture-MS Homo sapiens
215 SYMPK 8189
Affinity Capture-MS Homo sapiens
216 HS2ST1 9653
Affinity Capture-MS Homo sapiens
217 IFT81 28981
Affinity Capture-MS Homo sapiens
218 ALDH16A1 126133
Affinity Capture-MS Homo sapiens
219 PRPF8 10594
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 AMFR 267
Affinity Capture-MS Homo sapiens
221 COPG1 22820
Affinity Capture-MS Homo sapiens
222 EIF2B5 8893
Affinity Capture-MS Homo sapiens
223 UBAP2L 9898
Affinity Capture-MS Homo sapiens
224 BAG6 7917
Affinity Capture-MS Homo sapiens
225 POLA2  
Affinity Capture-MS Homo sapiens
226 IFI27L1  
Affinity Capture-MS Homo sapiens
227 SNRNP200 23020
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
228 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
229 CCNB1 891
Affinity Capture-MS Homo sapiens
230 KDM1A 23028
Affinity Capture-MS Homo sapiens
231 TUBA1C 84790
Affinity Capture-MS Homo sapiens
232 CSTF3 1479
Affinity Capture-MS Homo sapiens
233 HAUS8  
Affinity Capture-MS Homo sapiens
234 PLK1 5347
Affinity Capture-MS Homo sapiens
235 UQCRC1 7384
Affinity Capture-MS Homo sapiens
236 CTR9 9646
Affinity Capture-MS Homo sapiens
237 COG5 10466
Affinity Capture-MS Homo sapiens
238 TIMELESS  
Affinity Capture-MS Homo sapiens
239 SETD7 80854
Affinity Capture-MS Homo sapiens
240 RAD21 5885
Affinity Capture-MS Homo sapiens
241 ABCB7 22
Affinity Capture-MS Homo sapiens
242 PBK  
Affinity Capture-MS Homo sapiens
243 TPX2  
Affinity Capture-MS Homo sapiens
244 MRPL44  
Affinity Capture-MS Homo sapiens
245 NOMO2 283820
Affinity Capture-MS Homo sapiens
246 SGPL1 8879
Affinity Capture-MS Homo sapiens
247 ACLY 47
Affinity Capture-MS Homo sapiens
248 C11orf57  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
249 TMPO 7112
Affinity Capture-MS Homo sapiens
250 XPO1 7514
Affinity Capture-MS Homo sapiens
251 GLMN 11146
Affinity Capture-MS Homo sapiens
252 UBAP2 55833
Affinity Capture-MS Homo sapiens
253 FAM50B  
Affinity Capture-MS Homo sapiens
254 ELP3 55140
Affinity Capture-MS Homo sapiens
255 NUP88 4927
Affinity Capture-MS Homo sapiens
256 TNPO3 23534
Affinity Capture-MS Homo sapiens
257 HSD17B10 3028
Affinity Capture-MS Homo sapiens
258 WAPAL  
Affinity Capture-MS Homo sapiens
259 EFTUD2 9343
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
260 RANBP9 10048
Affinity Capture-MS Homo sapiens
261 DMAP1 55929
Affinity Capture-MS Homo sapiens
262 PTBP2  
Affinity Capture-MS Homo sapiens
263 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
264 DYNC1LI1 51143
Affinity Capture-MS Homo sapiens
265 ACAD9 28976
Affinity Capture-MS Homo sapiens