Gene description for CWC27
Gene name CWC27 spliceosome-associated protein homolog (S. cerevisiae)
Gene symbol CWC27
Other names/aliases NY-CO-10
SDCCAG10
Species Homo sapiens
 Database cross references - CWC27
ExoCarta ExoCarta_10283
Entrez Gene 10283
HGNC 10664
UniProt Q6UX04  
 CWC27 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CWC27
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IC
    protein peptidyl-prolyl isomerization GO:0000413 IBA
    protein folding GO:0006457 IEA
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 IDA
 Experiment description of studies that identified CWC27 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CWC27
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CWC27 is involved
No pathways found





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