Gene description for DHX38
Gene name DEAH (Asp-Glu-Ala-His) box polypeptide 38
Gene symbol DHX38
Other names/aliases DDX38
PRP16
PRPF16
Species Homo sapiens
 Database cross references - DHX38
ExoCarta ExoCarta_9785
Vesiclepedia VP_9785
Entrez Gene 9785
HGNC 17211
MIM 605584
UniProt Q92620  
 DHX38 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DHX38
Molecular Function
    ATP binding GO:0005524 IEA
    poly(A) RNA binding GO:0044822 IDA
    ATP-dependent RNA helicase activity GO:0004004 IBA
    protein binding GO:0005515 IPI
Biological Process
    mRNA 3'-end processing GO:0031124 TAS
    RNA splicing GO:0008380 TAS
    termination of RNA polymerase II transcription GO:0006369 TAS
    gene expression GO:0010467 TAS
    mRNA export from nucleus GO:0006406 TAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
Subcellular Localization
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    membrane GO:0016020 IDA
    catalytic step 2 spliceosome GO:0071013 IDA
 Experiment description of studies that identified DHX38 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DHX38
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP4C 5531
Affinity Capture-MS Homo sapiens
2 RNPS1 10921
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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