Gene description for LSM2
Gene name LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Gene symbol LSM2
Other names/aliases C6orf28
G7B
YBL026W
snRNP
Species Homo sapiens
 Database cross references - LSM2
ExoCarta ExoCarta_57819
Entrez Gene 57819
HGNC 13940
MIM 607282
UniProt Q9Y333  
 LSM2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for LSM2
Molecular Function
    protein kinase binding GO:0019901 IEA
    U6 snRNA binding GO:0017070 NAS
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    Ral GTPase binding GO:0017160 IPI
Biological Process
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    gene expression GO:0010467 TAS
    RNA splicing GO:0008380 TAS
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    catalytic step 2 spliceosome GO:0071013 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified LSM2 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LSM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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