Gene description for TRIM56
Gene name tripartite motif containing 56
Gene symbol TRIM56
Other names/aliases RNF109
Species Homo sapiens
 Database cross references - TRIM56
ExoCarta ExoCarta_81844
Entrez Gene 81844
HGNC 19028
UniProt Q9BRZ2  
 TRIM56 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TRIM56
Molecular Function
    zinc ion binding GO:0008270 IEA
    poly(A) RNA binding GO:0044822 IDA
    ubiquitin-protein transferase activity GO:0004842 TAS
    ligase activity GO:0016874 IEA
Biological Process
    negative regulation of viral release from host cell GO:1902187 IEA
    defense response to virus GO:0051607 ISS
    innate immune response GO:0045087 TAS
    regulation of type I interferon production GO:0032479 TAS
    interferon-beta production GO:0032608 ISS
    positive regulation of type I interferon production GO:0032481 TAS
    response to type I interferon GO:0034340 ISS
    protein K63-linked ubiquitination GO:0070534 ISS
    negative regulation of viral entry into host cell GO:0046597 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified TRIM56 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRIM56
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRIM56 is involved
PathwayEvidenceSource
Regulation of innate immune responses to cytosolic DNA TAS Reactome





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