Gene description for SNX2
Gene name sorting nexin 2
Gene symbol SNX2
Other names/aliases TRG-9
Species Homo sapiens
 Database cross references - SNX2
ExoCarta ExoCarta_6643
Entrez Gene 6643
HGNC 11173
MIM 605929
UniProt O60749  
 SNX2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for SNX2
Molecular Function
    transferrin receptor binding GO:1990459 IDA
    epidermal growth factor receptor binding GO:0005154 IDA
    leptin receptor binding GO:1990460 IDA
    phosphatidylinositol binding GO:0035091 IBA
    insulin receptor binding GO:0005158 IDA
    protein binding GO:0005515 IPI
Biological Process
    lamellipodium morphogenesis GO:0072673 IDA
    vesicle organization GO:0016050 IBA
    endocytosis GO:0006897 IBA
    protein oligomerization GO:0051259 IDA
    retrograde transport, endosome to Golgi GO:0042147 IMP
    early endosome to Golgi transport GO:0034498 IBA
    intracellular protein transport GO:0006886 IEA
Subcellular Localization
    endosome membrane GO:0010008 IDA
    membrane GO:0016020 IDA
    extrinsic component of membrane GO:0019898 IBA
    protein complex GO:0043234 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    early endosome membrane GO:0031901 IEA
    lamellipodium GO:0030027 IEA
    extracellular exosome GO:0070062 IDA
    endosome GO:0005768 IBA
    retromer complex GO:0030904 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified SNX2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNX1 6642
Invivo Homo sapiens
Invitro Homo sapiens
2 SNX2 6643
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
3 LEPR 3953
Invivo Homo sapiens
Invitro Homo sapiens
4 FNBP1 23048
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 PDGFRA  
Invivo Homo sapiens
Invitro Homo sapiens
6 ACVR1B 91
Invivo Homo sapiens
7 INSR 3643
Invivo Homo sapiens
Invitro Homo sapiens
8 ACVR2B  
Invitro Homo sapiens
9 SNX4 8723
Invivo Homo sapiens
Invitro Homo sapiens
10 EGFR 1956
Invivo Homo sapiens
Invitro Homo sapiens
11 PDGFRB 5159
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
12 SNX6 58533
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SNX2 is involved
PathwayEvidenceSource
Golgi Associated Vesicle Biogenesis TAS Reactome





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