Gene description for ZRANB1
Gene name zinc finger, RAN-binding domain containing 1
Gene symbol ZRANB1
Other names/aliases TRABID
Species Homo sapiens
 Database cross references - ZRANB1
ExoCarta ExoCarta_54764
Entrez Gene 54764
HGNC 18224
MIM 611749
UniProt Q9UGI0  
 ZRANB1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ZRANB1
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-specific protease activity GO:0004843 IDA
    zinc ion binding GO:0008270 IEA
    K63-linked polyubiquitin binding GO:0070530 IDA
Biological Process
    Wnt signaling pathway GO:0016055 IEA
    regulation of cell morphogenesis GO:0022604 IMP
    cell migration GO:0016477 IMP
    protein deubiquitination involved in ubiquitin-dependent protein catabolic process GO:0071947 IMP
    cytoskeleton organization GO:0007010 IMP
    protein K29-linked deubiquitination GO:0035523 IDA
    positive regulation of Wnt signaling pathway GO:0030177 IMP
    protein K33-linked deubiquitination GO:1990168 IDA
    protein K63-linked deubiquitination GO:0070536 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified ZRANB1 in exosomes
Experiment ID 226
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ZRANB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF6 7189
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which ZRANB1 is involved
No pathways found

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