Gene description for ZRANB1
Gene name zinc finger, RAN-binding domain containing 1
Gene symbol ZRANB1
Other names/aliases TRABID
Species Homo sapiens
 Database cross references - ZRANB1
ExoCarta ExoCarta_54764
Vesiclepedia VP_54764
Entrez Gene 54764
HGNC 18224
MIM 611749
UniProt Q9UGI0  
 ZRANB1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ZRANB1
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IBA
    cysteine-type deubiquitinase activity GO:0004843 IDA
    cysteine-type deubiquitinase activity GO:0004843 IMP
    protein binding GO:0005515 IPI
    polyubiquitin modification-dependent protein binding GO:0031593 IDA
    metal ion binding GO:0046872 IEA
    K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IBA
    K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IDA
    deubiquitinase activity GO:0101005 IDA
Biological Process
    cytoskeleton organization GO:0007010 IBA
    cytoskeleton organization GO:0007010 IMP
    Wnt signaling pathway GO:0016055 IEA
    cell migration GO:0016477 IBA
    cell migration GO:0016477 IMP
    protein deubiquitination GO:0016579 IDA
    regulation of cell morphogenesis GO:0022604 IMP
    positive regulation of Wnt signaling pathway GO:0030177 IBA
    positive regulation of Wnt signaling pathway GO:0030177 IMP
    protein K29-linked deubiquitination GO:0035523 IDA
    protein K63-linked deubiquitination GO:0070536 IDA
    protein K63-linked deubiquitination GO:0070536 IMP
    protein deubiquitination involved in ubiquitin-dependent protein catabolic process GO:0071947 IBA
    protein deubiquitination involved in ubiquitin-dependent protein catabolic process GO:0071947 IMP
    protein K33-linked deubiquitination GO:1990168 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified ZRANB1 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ZRANB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCAR1 55749
Affinity Capture-MS Homo sapiens
2 FAM208A  
Affinity Capture-MS Homo sapiens
3 RPUSD4 84881
Affinity Capture-MS Homo sapiens
4 SMC3 9126
Affinity Capture-MS Homo sapiens
5 TRPM4 54795
Affinity Capture-MS Homo sapiens
6 SIPA1L3  
Affinity Capture-MS Homo sapiens
7 UBL4A 8266
Affinity Capture-MS Homo sapiens
8 MED17  
Affinity Capture-MS Homo sapiens
9 ADCK3  
Affinity Capture-MS Homo sapiens
10 TRRAP 8295
Affinity Capture-MS Homo sapiens
11 RABEP2 79874
Affinity Capture-MS Homo sapiens
12 ATXN2L 11273
Affinity Capture-MS Homo sapiens
13 KCTD10 83892
Affinity Capture-MS Homo sapiens
14 GLB1 2720
Affinity Capture-MS Homo sapiens
15 ALB 213
Affinity Capture-MS Homo sapiens
16 APC  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
17 ARAF 369
Affinity Capture-MS Homo sapiens
18 STRN3 29966
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LTN1 26046
Affinity Capture-MS Homo sapiens
20 CORO7 79585
Biochemical Activity Homo sapiens
21 USP16  
Affinity Capture-MS Homo sapiens
22 UBC 7316
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
23 FANCI 55215
Affinity Capture-MS Homo sapiens
24 TRMT6 51605
Affinity Capture-MS Homo sapiens
25 TRIM62  
Affinity Capture-MS Homo sapiens
26 KIF7 374654
Affinity Capture-MS Homo sapiens
27 SOX9  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 CASP14 23581
Affinity Capture-MS Homo sapiens
29 CPT1A 1374
Affinity Capture-MS Homo sapiens
30 ZNF414  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 NUP160 23279
Affinity Capture-MS Homo sapiens
32 WDTC1 23038
Affinity Capture-MS Homo sapiens
33 LRPPRC 10128
Affinity Capture-MS Homo sapiens
34 PAAF1 80227
Affinity Capture-MS Homo sapiens
35 TOP2A 7153
Affinity Capture-MS Homo sapiens
36 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
37 CDC16 8881
Affinity Capture-MS Homo sapiens
38 RBM6 10180
Affinity Capture-MS Homo sapiens
39 STRN 6801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
40 FBXO3  
Affinity Capture-MS Homo sapiens
41 SPECC1L 23384
Affinity Capture-MS Homo sapiens
42 VARS 7407
Affinity Capture-MS Homo sapiens
43 HELZ 9931
Affinity Capture-MS Homo sapiens
44 PTRHD1 391356
Affinity Capture-MS Homo sapiens
45 CCDC137  
Affinity Capture-MS Homo sapiens
46 HYOU1 10525
Affinity Capture-MS Homo sapiens
47 PMF1  
Affinity Capture-MS Homo sapiens
48 PARVA 55742
Affinity Capture-MS Homo sapiens
49 LRRC41 10489
Affinity Capture-MS Homo sapiens
50 SMC2 10592
Affinity Capture-MS Homo sapiens
51 BCKDHA 593
Affinity Capture-MS Homo sapiens
52 HECW2  
Affinity Capture-MS Homo sapiens
53 GNE 10020
Affinity Capture-MS Homo sapiens
54 POLRMT 5442
Affinity Capture-MS Homo sapiens
55 RPIA 22934
Affinity Capture-MS Homo sapiens
56 HERC2 8924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
57 ERAL1  
Affinity Capture-MS Homo sapiens
58 UCHL5 51377
Affinity Capture-MS Homo sapiens
59 MYCBP2 23077
Affinity Capture-MS Homo sapiens
60 ANAPC7 51434
Affinity Capture-MS Homo sapiens
61 MAP4K4 9448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 STRIP1 85369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 SESTD1 91404
Affinity Capture-MS Homo sapiens
64 TRIM25 7706
Affinity Capture-MS Homo sapiens
65 VPS16 64601
Affinity Capture-MS Homo sapiens
66 PBLD 64081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CTTNBP2NL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 HIF1AN 55662
Affinity Capture-MS Homo sapiens
69 VPS33A 65082
Affinity Capture-MS Homo sapiens
70 PIK3C3 5289
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
71 CIAO1 9391
Affinity Capture-MS Homo sapiens
72 CHD1 1105
Affinity Capture-MS Homo sapiens
73 TFB1M  
Affinity Capture-MS Homo sapiens
74 UBR4 23352
Affinity Capture-MS Homo sapiens
75 CRYZL1 9946
Affinity Capture-MS Homo sapiens
76 PCNT  
Affinity Capture-MS Homo sapiens
77 MOXD1 26002
Affinity Capture-MS Homo sapiens
78 POLD1 5424
Affinity Capture-MS Homo sapiens
79 SHPRH  
Affinity Capture-MS Homo sapiens
80 CDC23 8697
Affinity Capture-MS Homo sapiens
81 RFC5 5985
Affinity Capture-MS Homo sapiens
82 MOB4 25843
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 ANKRD17 26057
Affinity Capture-MS Homo sapiens
84 NMD3 51068
Affinity Capture-MS Homo sapiens
85 PGAM5 192111
Affinity Capture-MS Homo sapiens
86 PPP6R2 9701
Affinity Capture-MS Homo sapiens
87 DCTN5 84516
Affinity Capture-MS Homo sapiens
88 SUPT5H 6829
Affinity Capture-MS Homo sapiens
89 ACACA 31
Affinity Capture-MS Homo sapiens
90 XRN1 54464
Affinity Capture-MS Homo sapiens
91 PHKA1 5255
Affinity Capture-MS Homo sapiens
92 PRKAG1 5571
Affinity Capture-MS Homo sapiens
93 TNKS1BP1 85456
Affinity Capture-MS Homo sapiens
94 BAG6 7917
Affinity Capture-MS Homo sapiens
95 NCAPH2  
Affinity Capture-MS Homo sapiens
96 UBAC2 337867
Affinity Capture-MS Homo sapiens
97 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
98 GCC2 9648
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 RCCD1  
Affinity Capture-MS Homo sapiens
100 NCAPD3 23310
Affinity Capture-MS Homo sapiens
101 SAFB2 9667
Affinity Capture-MS Homo sapiens
102 PDS5A 23244
Affinity Capture-MS Homo sapiens
103 CCDC85C  
Affinity Capture-MS Homo sapiens
104 MRPS6  
Affinity Capture-MS Homo sapiens
105 IQCB1  
Affinity Capture-MS Homo sapiens
106 MIA3 375056
Affinity Capture-MS Homo sapiens
107 DICER1  
Affinity Capture-MS Homo sapiens
108 BICD2 23299
Affinity Capture-MS Homo sapiens
109 TRIP11 9321
Affinity Capture-MS Homo sapiens
110 TPP2 7174
Affinity Capture-MS Homo sapiens
111 HECTD1 25831
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
112 ZFC3H1 196441
Affinity Capture-MS Homo sapiens
113 GCLC 2729
Affinity Capture-MS Homo sapiens
114 NKTR  
Affinity Capture-MS Homo sapiens
115 SUPT6H 6830
Affinity Capture-MS Homo sapiens
116 SRP68 6730
Affinity Capture-MS Homo sapiens
117 MPDZ  
Affinity Capture-MS Homo sapiens
118 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
119 CTTNBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 RMND5A 64795
Affinity Capture-MS Homo sapiens
121 PIPSL 266971
Affinity Capture-MS Homo sapiens
122 AGK 55750
Affinity Capture-MS Homo sapiens
123 CACYBP 27101
Affinity Capture-MS Homo sapiens
124 UBR2 23304
Affinity Capture-MS Homo sapiens
125 IKBKG 8517
Affinity Capture-MS Homo sapiens
126 TWIST1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
127 NEURL4  
Affinity Capture-MS Homo sapiens
128 SNX1 6642
Affinity Capture-MS Homo sapiens
129 DST 667
Affinity Capture-MS Homo sapiens
130 BIRC2  
Affinity Capture-MS Homo sapiens
131 UBE2S  
Biochemical Activity Homo sapiens
132 PDE12 201626
Affinity Capture-MS Homo sapiens
133 UFD1L 7353
Affinity Capture-MS Homo sapiens
134 TRIO 7204
Affinity Capture-MS Homo sapiens
135 ITPR2 3709
Affinity Capture-MS Homo sapiens
136 SLC25A12 8604
Affinity Capture-MS Homo sapiens
137 CDK7 1022
Affinity Capture-MS Homo sapiens
138 HTRA2 27429
Affinity Capture-MS Homo sapiens
139 CDC73  
Affinity Capture-MS Homo sapiens
140 PAN2  
Affinity Capture-MS Homo sapiens
141 BCKDHB 594
Affinity Capture-MS Homo sapiens
142 PMF1-BGLAP  
Affinity Capture-MS Homo sapiens
143 UBE3A 7337
Affinity Capture-MS Homo sapiens
144 GPX1 2876
Affinity Capture-MS Homo sapiens
145 Hectd1  
Affinity Capture-Western Mus musculus
146 RLIM 51132
Affinity Capture-MS Homo sapiens
147 KCMF1 56888
Affinity Capture-MS Homo sapiens
148 SREBF1 6720
Positive Genetic Homo sapiens
149 TRAF6 7189
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
150 RMND1 55005
Affinity Capture-MS Homo sapiens
151 SBF1 6305
Affinity Capture-MS Homo sapiens
152 WAPAL  
Affinity Capture-MS Homo sapiens
153 NXF1 10482
Affinity Capture-RNA Homo sapiens
154 DCAF8 50717
Affinity Capture-MS Homo sapiens
155 ECI2 10455
Affinity Capture-MS Homo sapiens
156 HAUS5 23354
Affinity Capture-MS Homo sapiens
157 FARSB 10056
Affinity Capture-MS Homo sapiens
158 CUL9  
Affinity Capture-MS Homo sapiens
159 ANKRD52 283373
Affinity Capture-MS Homo sapiens
160 NADSYN1 55191
Affinity Capture-MS Homo sapiens
161 UBR1 197131
Affinity Capture-MS Homo sapiens
162 MYO6 4646
Affinity Capture-MS Homo sapiens
163 NRD1 4898
Affinity Capture-MS Homo sapiens
164 USP47 55031
Affinity Capture-MS Homo sapiens
165 JAK1 3716
Affinity Capture-MS Homo sapiens
166 MCMBP 79892
Affinity Capture-MS Homo sapiens
167 AKAP5  
Affinity Capture-MS Homo sapiens
168 PSAP 5660
Affinity Capture-MS Homo sapiens
169 DHPS 1725
Affinity Capture-MS Homo sapiens
170 USP24 23358
Affinity Capture-MS Homo sapiens
171 SLC30A7 148867
Affinity Capture-MS Homo sapiens
172 TCEB2 6923
Affinity Capture-MS Homo sapiens
173 CUL7 9820
Affinity Capture-MS Homo sapiens
174 SMN1 6606
Affinity Capture-MS Homo sapiens
175 DHX37  
Affinity Capture-MS Homo sapiens
176 AIP 9049
Affinity Capture-MS Homo sapiens
177 RBP1 5947
Affinity Capture-MS Homo sapiens
178 RNF114 55905
Affinity Capture-MS Homo sapiens
179 AKT1 207
Biochemical Activity Homo sapiens
180 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
181 ARID2  
Affinity Capture-MS Homo sapiens
182 MAP7D2 256714
Affinity Capture-MS Homo sapiens
183 RRAGC 64121
Affinity Capture-MS Homo sapiens
184 RRP15  
Affinity Capture-MS Homo sapiens
185 IKBKAP 8518
Affinity Capture-MS Homo sapiens
186 Btrc  
Affinity Capture-Western Mus musculus
187 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 TRAF2 7186
Affinity Capture-MS Homo sapiens
189 MPP6 51678
Affinity Capture-MS Homo sapiens
190 SLMAP 7871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 NUP133 55746
Affinity Capture-MS Homo sapiens
192 SRRM1 10250
Affinity Capture-MS Homo sapiens
193 MAX  
Affinity Capture-MS Homo sapiens
194 USP34 9736
Affinity Capture-MS Homo sapiens
195 URGCP 55665
Affinity Capture-MS Homo sapiens
196 STRIP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
197 PDCD2L 84306
Affinity Capture-MS Homo sapiens
198 HECTD3 79654
Affinity Capture-MS Homo sapiens
199 STRN4 29888
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
200 B3GALT6 126792
Affinity Capture-MS Homo sapiens
201 KEAP1 9817
Affinity Capture-MS Homo sapiens
202 TUBG1 7283
Affinity Capture-MS Homo sapiens
203 ZZEF1 23140
Affinity Capture-MS Homo sapiens
204 SQSTM1 8878
Affinity Capture-MS Homo sapiens
205 ANAPC1 64682
Affinity Capture-MS Homo sapiens
206 PIK3R4 30849
Affinity Capture-MS Homo sapiens
207 PJA2  
Affinity Capture-MS Homo sapiens
208 PDCD2 5134
Affinity Capture-MS Homo sapiens
209 MKI67  
Affinity Capture-MS Homo sapiens
210 SUGP2  
Affinity Capture-MS Homo sapiens
211 UBE3C 9690
Affinity Capture-MS Homo sapiens
212 TRIP12 9320
Affinity Capture-MS Homo sapiens
213 MOV10 4343
Affinity Capture-RNA Homo sapiens
214 EZH2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
215 FGFR1OP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
216 CYHR1  
Affinity Capture-MS Homo sapiens
217 CXorf56  
Affinity Capture-MS Homo sapiens
218 SSSCA1 10534
Affinity Capture-MS Homo sapiens
219 PIH1D1  
Affinity Capture-MS Homo sapiens
220 SNX2 6643
Affinity Capture-MS Homo sapiens
221 YME1L1 10730
Affinity Capture-MS Homo sapiens
222 RARS 5917
Affinity Capture-MS Homo sapiens
223 CYFIP1 23191
Affinity Capture-MS Homo sapiens
224 TMEM31  
Affinity Capture-MS Homo sapiens
225 SEC61A1 29927
Affinity Capture-MS Homo sapiens
226 SIKE1  
Affinity Capture-MS Homo sapiens
227 NEMF 9147
Affinity Capture-MS Homo sapiens
228 RBCK1  
Affinity Capture-MS Homo sapiens
229 PSME4 23198
Affinity Capture-MS Homo sapiens
230 KIF4A 24137
Affinity Capture-MS Homo sapiens
231 SEPHS1 22929
Affinity Capture-MS Homo sapiens
232 ARIH1 25820
Affinity Capture-MS Homo sapiens
233 Apc  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
234 CAPN2 824
Affinity Capture-MS Homo sapiens
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