Gene description for LRRC41
Gene name leucine rich repeat containing 41
Gene symbol LRRC41
Other names/aliases MUF1
PP7759
Species Homo sapiens
 Database cross references - LRRC41
ExoCarta ExoCarta_10489
Vesiclepedia VP_10489
Entrez Gene 10489
HGNC 16917
UniProt Q15345  
 LRRC41 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRRC41
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IEA
Biological Process
    protein ubiquitination GO:0016567 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified LRRC41 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRRC41
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZRANB1 54764
Affinity Capture-MS Homo sapiens
2 SUGT1 10910
Affinity Capture-MS Homo sapiens
3 KRTAP3-1  
Two-hybrid Homo sapiens
4 DPYSL5  
Affinity Capture-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 FASN 2194
Positive Genetic Homo sapiens
7 TCEB1 6921
Affinity Capture-MS Homo sapiens
8 CENPA  
Proximity Label-MS Homo sapiens
9 COIL  
Proximity Label-MS Homo sapiens
10 NSMCE1  
Affinity Capture-MS Homo sapiens
11 GPR17 2840
Affinity Capture-MS Homo sapiens
12 LIPH 200879
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EXOC8 149371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 COX4I2 84701
Affinity Capture-MS Homo sapiens
15 C9orf78 51759
Affinity Capture-MS Homo sapiens
16 LMNB1 4001
Proximity Label-MS Homo sapiens
17 LDLRAD1  
Affinity Capture-MS Homo sapiens
18 ITLN1 55600
Affinity Capture-MS Homo sapiens
19 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
20 KRT34  
Two-hybrid Homo sapiens
21 S100A2 6273
Affinity Capture-MS Homo sapiens
22 CUL5 8065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 FHL5 9457
Two-hybrid Homo sapiens
24 CUL3 8452
Affinity Capture-MS Homo sapiens
25 NR3C1 2908
Proximity Label-MS Homo sapiens
26 BPNT1 10380
Affinity Capture-MS Homo sapiens
27 METTL21B  
Affinity Capture-MS Homo sapiens
28 DRG1 4733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 RIPK4  
Affinity Capture-MS Homo sapiens
30 RNF7  
Affinity Capture-MS Homo sapiens
31 NXF1 10482
Affinity Capture-RNA Homo sapiens
32 APEX1 328
Affinity Capture-RNA Homo sapiens
33 ERCC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LCN8  
Affinity Capture-MS Homo sapiens
35 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
36 RPA3 6119
Proximity Label-MS Homo sapiens
37 NDOR1  
Affinity Capture-MS Homo sapiens
38 BARD1 580
Affinity Capture-MS Homo sapiens
39 CYSRT1 375791
Two-hybrid Homo sapiens
40 NTRK1 4914
Affinity Capture-MS Homo sapiens
41 KRTAP6-2  
Two-hybrid Homo sapiens
42 MYO9B 4650
Two-hybrid Homo sapiens
43 TEAD2  
Affinity Capture-MS Homo sapiens
44 BRD1 23774
Affinity Capture-MS Homo sapiens
45 TCEB2 6923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FLYWCH2  
Affinity Capture-MS Homo sapiens
47 DDRGK1 65992
Affinity Capture-MS Homo sapiens
48 UNC5CL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 C9orf72  
Affinity Capture-MS Homo sapiens
50 POU5F1  
Affinity Capture-MS Homo sapiens
51 FBL 2091
Affinity Capture-MS Homo sapiens
52 CCND1 595
Affinity Capture-MS Homo sapiens
53 RBPMS 11030
Two-hybrid Homo sapiens
54 Ostm1  
Affinity Capture-MS Mus musculus
55 AKAP1 8165
Proximity Label-MS Homo sapiens
56 CPSF3 51692
Affinity Capture-MS Homo sapiens
57 PPP3CC 5533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 SPCS3 60559
Affinity Capture-MS Homo sapiens
59 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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