Gene description for LIPH
Gene name lipase, member H
Gene symbol LIPH
Other names/aliases AH
ARWH2
HYPT7
LAH2
LPDLR
PLA1B
mPA-PLA1
Species Homo sapiens
 Database cross references - LIPH
ExoCarta ExoCarta_200879
Vesiclepedia VP_200879
Entrez Gene 200879
HGNC 18483
MIM 607365
UniProt Q8WWY8  
 LIPH identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for LIPH
Molecular Function
    phospholipase activity GO:0004620 IBA
    phospholipase activity GO:0004620 IDA
    phospholipase activity GO:0004620 TAS
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IDA
Biological Process
    phosphatidic acid biosynthetic process GO:0006654 TAS
    lipid catabolic process GO:0016042 IBA
    lipid catabolic process GO:0016042 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified LIPH in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for LIPH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUDCD1 84955
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GDF11 10220
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TARSL2 123283
Affinity Capture-MS Homo sapiens
4 CLN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DDX11L8  
Affinity Capture-MS Homo sapiens
6 FPGS 2356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZNHIT6 54680
Affinity Capture-MS Homo sapiens
8 CDC42SE2 56990
Affinity Capture-MS Homo sapiens
9 ITIH2 3698
Affinity Capture-MS Homo sapiens
10 P3H4 10609
Affinity Capture-MS Homo sapiens
11 PHLDB3  
Affinity Capture-MS Homo sapiens
12 ECD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MAP1S 55201
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MKS1 54903
Affinity Capture-MS Homo sapiens
15 FAT1 2195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 FLT4  
Affinity Capture-MS Homo sapiens
18 B4GALT5 9334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 BRIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PRKACG  
Affinity Capture-MS Homo sapiens
21 DPYSL4 10570
Affinity Capture-MS Homo sapiens
22 FREM2 341640
Affinity Capture-MS Homo sapiens
23 ANAPC1 64682
Affinity Capture-MS Homo sapiens
24 NAGLU 4669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 EGFL7 51162
Affinity Capture-MS Homo sapiens
26 CEACAM21  
Affinity Capture-MS Homo sapiens
27 COL18A1 80781
Affinity Capture-MS Homo sapiens
28 TUBA1A 7846
Affinity Capture-MS Homo sapiens
29 MSTO1 55154
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
31 ZNF318 24149
Affinity Capture-MS Homo sapiens
32 TUBA4A 7277
Affinity Capture-MS Homo sapiens
33 MANBA 4126
Affinity Capture-MS Homo sapiens
34 ACACA 31
Affinity Capture-MS Homo sapiens
35 FUT11 170384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 HDAC3 8841
Affinity Capture-MS Homo sapiens
37 CAMK2B 816
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 DYRK1A 1859
Affinity Capture-MS Homo sapiens
39 LRP5 4041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 TRMT1 55621
Affinity Capture-MS Homo sapiens
41 FRAS1 80144
Affinity Capture-MS Homo sapiens
42 CEP164  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ALDH3A1 218
Affinity Capture-MS Homo sapiens
44 DHFRL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PRIM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 LRRC41 10489
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PTER 9317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 DHX32  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 POLA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 DNAJC12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 HAUS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 C3orf52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 NAA10 8260
Affinity Capture-MS Homo sapiens
54 CERCAM 51148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RTEL1 51750
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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