Gene description for CDC42SE2
Gene name CDC42 small effector 2
Gene symbol CDC42SE2
Other names/aliases SPEC2
Species Homo sapiens
 Database cross references - CDC42SE2
ExoCarta ExoCarta_56990
Entrez Gene 56990
HGNC 18547
UniProt Q9NRR3  
 CDC42SE2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CDC42SE2
Molecular Function
    structural molecule activity GO:0005198 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of signal transduction GO:0009966 IDA
    regulation of cell shape GO:0008360 IEA
    phagocytosis GO:0006909 IEA
    signal transduction GO:0007165 IBA
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IDA
    extracellular exosome GO:0070062 IDA
    phagocytic cup GO:0001891 IEA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified CDC42SE2 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CDC42SE2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAC1 5879
Two-hybrid Homo sapiens
2 CDC42 998
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CDC42SE2 is involved
No pathways found





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