Gene description for LRP5
Gene name	low density lipoprotein receptor-related protein 5
Gene symbol	LRP5
Other names/aliases	BMND1 EVR1 EVR4 HBM LR3 LRP-5 LRP7 OPPG OPS OPTA1 VBCH2
Species	Homo sapiens
Database cross references - LRP5
ExoCarta	ExoCarta_4041
Entrez Gene	4041
HGNC	6697
MIM	603506
UniProt	O75197
LRP5 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513

Gene ontology annotations for LRP5

Molecular Function     protein binding GO:0005515 IPI     toxin transporter activity GO:0019534 IMP     Wnt-activated receptor activity GO:0042813 IBA     Wnt-protein binding GO:0017147 IBA Biological Process     regulation of bone remodeling GO:0046850 IEA     retina morphogenesis in camera-type eye GO:0060042 IMP     endocytosis GO:0006897 IEA     osteoblast development GO:0002076 IBA     anatomical structure regression GO:0060033 IEA     somatic stem cell maintenance GO:0035019 IEA     bone marrow development GO:0048539 IMP     bone remodeling GO:0046849 IEA     anterior/posterior pattern specification GO:0009952 IEA     positive regulation of mitotic nuclear division GO:0045840 IDA     regulation of apoptotic process GO:0042981 IEA     Wnt signaling pathway GO:0016055 IDA     regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 IBA     positive regulation of cell proliferation GO:0008284 IDA     cholesterol homeostasis GO:0042632 IMP     positive regulation of fat cell differentiation GO:0045600 IMP     embryonic digit morphogenesis GO:0042733 IEA     regulation of canonical Wnt signaling pathway GO:0060828 IMP     response to peptide hormone GO:0043434 IEA     positive regulation of transcription, DNA-templated GO:0045893 IDA     adipose tissue development GO:0060612 IMP     gastrulation with mouth forming second GO:0001702 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS     branching involved in mammary gland duct morphogenesis GO:0060444 IEA     Wnt signaling pathway involved in dorsal/ventral axis specification GO:0044332 IDA     regulation of blood pressure GO:0008217 IMP     cell-cell signaling involved in mammary gland development GO:0060764 IEA     cell migration involved in gastrulation GO:0042074 IEA     glucose catabolic process GO:0006007 IMP     negative regulation of protein serine/threonine kinase activity GO:0071901 IMP     positive regulation of osteoblast proliferation GO:0033690 IEA     extracellular matrix-cell signaling GO:0035426 IEA     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IEA     canonical Wnt signaling pathway GO:0060070 IMP     retinal blood vessel morphogenesis GO:0061304 IMP     cholesterol metabolic process GO:0008203 IEA     negative regulation of osteoblast differentiation GO:0045668 IMP     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     positive regulation of mesenchymal cell proliferation GO:0002053 IMP     apoptotic process involved in patterning of blood vessels GO:1902262 IEA     bone morphogenesis GO:0060349 IMP Subcellular Localization     endoplasmic reticulum GO:0005783 IEA     mitochondrion GO:0005739 IEA     integral component of membrane GO:0016021 IEA     plasma membrane GO:0005886 TAS     receptor complex GO:0043235 IDA