Gene description for LRP5
Gene name low density lipoprotein receptor-related protein 5
Gene symbol LRP5
Other names/aliases BMND1
EVR1
EVR4
HBM
LR3
LRP-5
LRP7
OPPG
OPS
OPTA1
VBCH2
Species Homo sapiens
 Database cross references - LRP5
ExoCarta ExoCarta_4041
Entrez Gene 4041
HGNC 6697
MIM 603506
UniProt O75197  
 LRP5 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for LRP5
Molecular Function
    protein binding GO:0005515 IPI
    toxin transporter activity GO:0019534 IMP
    Wnt-activated receptor activity GO:0042813 IBA
    Wnt-protein binding GO:0017147 IBA
Biological Process
    regulation of bone remodeling GO:0046850 IEA
    retina morphogenesis in camera-type eye GO:0060042 IMP
    endocytosis GO:0006897 IEA
    osteoblast development GO:0002076 IBA
    anatomical structure regression GO:0060033 IEA
    somatic stem cell maintenance GO:0035019 IEA
    bone marrow development GO:0048539 IMP
    bone remodeling GO:0046849 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    positive regulation of mitotic nuclear division GO:0045840 IDA
    regulation of apoptotic process GO:0042981 IEA
    Wnt signaling pathway GO:0016055 IDA
    regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 IBA
    positive regulation of cell proliferation GO:0008284 IDA
    cholesterol homeostasis GO:0042632 IMP
    positive regulation of fat cell differentiation GO:0045600 IMP
    embryonic digit morphogenesis GO:0042733 IEA
    regulation of canonical Wnt signaling pathway GO:0060828 IMP
    response to peptide hormone GO:0043434 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    adipose tissue development GO:0060612 IMP
    gastrulation with mouth forming second GO:0001702 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 TAS
    branching involved in mammary gland duct morphogenesis GO:0060444 IEA
    Wnt signaling pathway involved in dorsal/ventral axis specification GO:0044332 IDA
    regulation of blood pressure GO:0008217 IMP
    cell-cell signaling involved in mammary gland development GO:0060764 IEA
    cell migration involved in gastrulation GO:0042074 IEA
    glucose catabolic process GO:0006007 IMP
    negative regulation of protein serine/threonine kinase activity GO:0071901 IMP
    positive regulation of osteoblast proliferation GO:0033690 IEA
    extracellular matrix-cell signaling GO:0035426 IEA
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IEA
    canonical Wnt signaling pathway GO:0060070 IMP
    retinal blood vessel morphogenesis GO:0061304 IMP
    cholesterol metabolic process GO:0008203 IEA
    negative regulation of osteoblast differentiation GO:0045668 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    positive regulation of mesenchymal cell proliferation GO:0002053 IMP
    apoptotic process involved in patterning of blood vessels GO:1902262 IEA
    bone morphogenesis GO:0060349 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    mitochondrion GO:0005739 IEA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified LRP5 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LRP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 THBS1 7057
Invivo Homo sapiens
2 AXIN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 FZD8  
Affinity Capture-Western Homo sapiens
4 MESDC2  
Affinity Capture-Western Homo sapiens
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