Gene description for ST8SIA4
Gene name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Gene symbol ST8SIA4
Other names/aliases PST
PST1
SIAT8D
ST8SIA-IV
Species Homo sapiens
 Database cross references - ST8SIA4
ExoCarta ExoCarta_7903
Vesiclepedia VP_7903
Entrez Gene 7903
HGNC 10871
MIM 602547
UniProt Q92187  
 ST8SIA4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ST8SIA4
Molecular Function
    alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0003828 IBA
    alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0003828 IDA
    alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0003828 TAS
    sialyltransferase activity GO:0008373 IDA
    sialic acid binding GO:0033691 IC
Biological Process
    ganglioside biosynthetic process GO:0001574 IDA
    protein glycosylation GO:0006486 IBA
    protein glycosylation GO:0006486 IDA
    protein glycosylation GO:0006486 IEA
    N-glycan processing GO:0006491 IBA
    N-glycan processing GO:0006491 IDA
    nervous system development GO:0007399 TAS
    oligosaccharide metabolic process GO:0009311 IBA
    oligosaccharide metabolic process GO:0009311 IDA
    protein modification process GO:0036211 TAS
    sialylation GO:0097503 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    extracellular region GO:0005576 IEA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified ST8SIA4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ST8SIA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLXNA1 5361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PRKD2 25865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LRP5 4041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 OAF 220323
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 BCAM 4059
Affinity Capture-MS Homo sapiens
6 NRP1 8829
Affinity Capture-MS Homo sapiens
7 SEMA4D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ADAM17 6868
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 B4GALNT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ITGB5 3693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SUSD1 64420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TMBIM6 7009
Affinity Capture-MS Homo sapiens
13 CNTNAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CLSTN3 9746
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EGFR 1956
Affinity Capture-MS Homo sapiens
16 FREM2 341640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NRSN1  
Affinity Capture-MS Homo sapiens
18 TUFM 7284
Affinity Capture-MS Homo sapiens
19 NOMO1 23420
Affinity Capture-MS Homo sapiens
20 FAT1 2195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ACTA2 59
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MRC2 9902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SUN2 25777
Affinity Capture-MS Homo sapiens
25 S100A2 6273
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 KIAA1467 57613
Affinity Capture-MS Homo sapiens
27 STK39 27347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 RUFY1 80230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ITGAV 3685
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CBWD1 55871
Affinity Capture-MS Homo sapiens
32 TMEM67 91147
Affinity Capture-MS Homo sapiens
33 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LNPEP 4012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ITPRIP  
Affinity Capture-MS Homo sapiens
36 IMPAD1 54928
Affinity Capture-MS Homo sapiens
37 NRP2 8828
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 DDX58 23586
Affinity Capture-RNA Homo sapiens
39 PLXNB2 23654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 AMIGO1  
Affinity Capture-MS Homo sapiens
41 KIAA0319L 79932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GYLTL1B 120071
Affinity Capture-MS Homo sapiens
44 CACHD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 GALNT18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ITGA7 3679
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CD109 135228
Affinity Capture-MS Homo sapiens
48 PTGFRN 5738
Affinity Capture-MS Homo sapiens
49 TMEM132A 54972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PLXNA3 55558
Affinity Capture-MS Homo sapiens
51 FAM69A 388650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CELSR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 FBXO2 26232
Affinity Capture-MS Homo sapiens
54 BACE2 25825
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 LRIG1 26018
Affinity Capture-MS Homo sapiens
56 SCGB2A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 HLA-F 3134
Affinity Capture-MS Homo sapiens
58 ADGRV1 84059
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 FRAS1 80144
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 NR2F2  
Affinity Capture-MS Homo sapiens
62 RNASEL 6041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 PTPRK 5796
Affinity Capture-MS Homo sapiens
64 HYAL2 8692
Affinity Capture-MS Homo sapiens
65 PDGFRA 5156
Affinity Capture-MS Homo sapiens
66 LRP11  
Affinity Capture-MS Homo sapiens
67 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 ITGA8 8516
Affinity Capture-MS Homo sapiens
69 TGFBR3 7049
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 PLXNA2 5362
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 EPHB4 2050
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 ANKRD46 157567
Affinity Capture-MS Homo sapiens
73 PTCH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 NDST2  
Affinity Capture-MS Homo sapiens
75 TUBB3 10381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 ST8SIA2  
Affinity Capture-MS Homo sapiens
77 C1QTNF7  
Affinity Capture-MS Homo sapiens
78 LRP6 4040
Affinity Capture-MS Homo sapiens
79 NLGN2 57555
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 ITGA4 3676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 HLA-C 3107
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 PTPRU  
Affinity Capture-MS Homo sapiens
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