Gene description for NRP2
Gene name neuropilin 2
Gene symbol NRP2
Other names/aliases NP2
NPN2
PRO2714
VEGF165R2
Species Homo sapiens
 Database cross references - NRP2
ExoCarta ExoCarta_8828
Entrez Gene 8828
HGNC 8005
MIM 602070
UniProt O60462  
 NRP2 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
 Gene ontology annotations for NRP2
Molecular Function
    heparin binding GO:0008201 IEA
    growth factor binding GO:0019838 TAS
    metal ion binding GO:0046872 IEA
    receptor activity GO:0004872 TAS
    semaphorin receptor activity GO:0017154 NAS
    cytokine binding GO:0019955 NAS
    vascular endothelial growth factor-activated receptor activity GO:0005021 NAS
Biological Process
    cell adhesion GO:0007155 NAS
    sympathetic neuron projection extension GO:0097490 ISS
    sympathetic neuron projection guidance GO:0097491 ISS
    sympathetic ganglion development GO:0061549 ISS
    angiogenesis GO:0001525 NAS
    axon guidance GO:0007411 TAS
    positive regulation of endothelial cell migration GO:0010595 TAS
    nerve development GO:0021675 ISS
    axon extension involved in axon guidance GO:0048846 ISS
    positive regulation of endothelial cell proliferation GO:0001938 TAS
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 ISS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
Subcellular Localization
    integral component of membrane GO:0016021 NAS
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    semaphorin receptor complex GO:0002116 NAS
 Experiment description of studies that identified NRP2 in exosomes
1
Experiment ID 254
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1|CD81
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 257
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 259
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 260
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1|CD81
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for NRP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEMA3B  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 PGF  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NRP2 is involved
PathwayEvidenceSource
Neurophilin interactions with VEGF and VEGFR TAS Reactome
NrCAM interactions TAS Reactome





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