Gene description for C1QA
Gene name complement component 1, q subcomponent, A chain
Gene symbol C1QA
Other names/aliases -
Species Homo sapiens
 Database cross references - C1QA
ExoCarta ExoCarta_712
Entrez Gene 712
HGNC 1241
MIM 120550
UniProt P02745  
 C1QA identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for C1QA
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    complement activation GO:0006956 TAS
    cell-cell signaling GO:0007267 TAS
    complement activation, classical pathway GO:0006958 TAS
    innate immune response GO:0045087 TAS
Subcellular Localization
    complement component C1 complex GO:0005602 TAS
    collagen trimer GO:0005581 IEA
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified C1QA in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C1QA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HRG 3273
Invivo Homo sapiens
2 APCS 325
Invitro Homo sapiens
3 DCN 1634
Reconstituted Complex Homo sapiens
4 C1S 716
Affinity Capture-Western Homo sapiens
5 PTX3 5806
Invitro Homo sapiens
Invivo Homo sapiens
6 FN1 2335
Reconstituted Complex Homo sapiens
7 COL2A1 1280
Invitro Homo sapiens
8 C1R 715
Affinity Capture-Western Homo sapiens
9 CR1 1378
Invitro Homo sapiens
10 C1QR1  
Invitro Homo sapiens
11 CRP  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which C1QA is involved
PathwayEvidenceSource
Classical antibody-mediated complement activation TAS Reactome
Initial triggering of complement TAS Reactome





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